heam

Question 1

hypersegmented neutrophils

Answer 1

megaloblastic anaemia

Question 2

treatment of thalassaemias

Answer 2

lifelong transfusions

Question 3

which bleeding disorders effect which clotting factors?

Answer 3

Heamophilia A - VIII
“ B - IX
von willibran - VII
vit K deficiency - II, VII, IX, X

Question 4

aPTT vs PT

Answer 4

aPTT - intrinsic clotting (heparin)
PT - extrinsic (warfarin)

Question 5

tear drop poikilocytes

Answer 5

myelofibrosis

Question 6

smudge cells

Answer 6

chronic lymphoblastic leukaemia

Question 7

richets transformation

Answer 7

CLL -> diffuse large B-cell lymphoma

Question 8

auer rods

Answer 8

acute myeloid leukaemia

Question 9

phildelphia chromosome

Answer 9

chronic myeloid leukeumia

Question 10

leukaemia in kids

Answer 10

acute lymphoblastic

Question 11

howell jolly bodies

Answer 11

hyposplenism (normally nuclear remnants removed by spleen)

Question 12

ring sideroblasts

Answer 12

myelodysplastic syndrome

Question 13

bronze skin

Answer 13

hereditary haemochromatosis??

Question 14

FBC thalassaemia

Answer 14

normal except decreased TIBC

Question 15

FBC anaemia of chronic disease

Answer 15

everything decreased except serum ferritin

Question 16

symptoms of lead poisoning

Answer 16

decreased transferrin
neurological symptoms

microcytic anaemia (TAILS)

Question 17

treatment of hyposplenism caused by sickle

Answer 17

proph penicillin

Question 18

treatment of sideroblastic anaemia

Answer 18

pyridoxine - B6

Question 19

pathology of ITP

Answer 19

antibodies against platelets

Question 20

mechanism of clopi

Answer 20

ADP antagonist

Question 21

complications of polycythemia vera

Answer 21

AML
myelofibrosis

Question 22

flava beans -> sick

Answer 22

G6PD deficiency

Question 23

what is factor V leidens mutation

Answer 23

activated protein C resistance

Question 24

investigation into multiple myeloma

Answer 24

whole body MRI

Question 25

INR calculation

Answer 25

(patients PTT/ normal PTT)ISI

Question 26

treatment of CML

Answer 26

imatinib

Question 27

what does CLL transform into

Answer 27

non-hodgkins

Question 28

treatment of ITP

Answer 28

oral steroids

Question 29

investigation into sickle

Answer 29

heamoglobin electrophoresis

Question 30

rate of RBC transfusion

Answer 30

not urgent - 2hrs urgent - STAT

Question 31

how long before surgery should you stop warfarin?

Answer 31

5 days

Question 32

treatment of hypercalceamia

Answer 32

saline

Question 33

plummer-vinson disease

Answer 33

dysphagia (oesophageal webs) glossitits iron deficient anaemia

Question 34

normocytic aneamia + low iron

Answer 34

anaemia of chronic disease

Question 35

pencil poikilocytes

Answer 35

iron deficient anaemia

Question 36

schistocytes

Answer 36

intravascular heamolysis - HUS

Question 37

spherocytes

Answer 37

autoimmune heamolytic anaemia

Question 38

basophilic stippling

Answer 38

thalassaemia lead poisoning

Question 39

heinz bodies

Answer 39

g6pd deficiency alpha thalassaemia

Question 40

Reed sternberg cells

Answer 40

hodgkins lymphoma

Question 41

burkitts lymphoma translocation

Answer 41

t(8;14)

Question 42

Waldenstorms macroglobinaemia

Answer 42

IgM paraprotein

Question 43

target cells

Answer 43

hyposplenism Iron deficiency sickle cell thalassaemia

Question 44

heparin induced thrombocytopaemia

Answer 44

antibodies against heparin hypercoaguable 5-10 days after treatment

Question 45

what causes a minor allergic reaction to blood transfusion

Answer 45

forgein plasma proteins

Question 46

what causes bacterial infection in transfusion

Answer 46

platelets

Question 47

intermittent fever + travel

Answer 47

malaria

Question 48

treatment of non hodgkins lymphoma

Answer 48

rituximab prednisilone

Question 49

history of leukaemia or lymphoma -> chemo -> renal failure + electrolyte imbalance

Answer 49

tumour lysis syndrome

Question 50

electrolyte imbalance in tumour lysis syndrome

Answer 50

increased urea !!!! increased potassium increased phosphate -> low calcium

Question 51

investigation into tumour lysis syndrome

Answer 51

serum uric acid

Question 52

treatment of tumour lysis syndrome

Answer 52

IV fluids

Question 53

lymphoma + AIDs

Answer 53

NON hodgkins

Question 54

hodgkins vs non

Answer 54

H - pain with alcohol, reed-sternburg, itch, cluster of nodes non - AIDs, random spread of nodes

Question 55

murmur associated with ADPKD

Answer 55

mitral prolapse

Question 56

treatment of von willebrands

Answer 56

desmopressin

Question 57

most common type of hodgkins lymphoma

Answer 57

nodular sclerosing lymphocyte predominant - best prognosis

Question 58

warm vs cold heamolytic aneamia

Answer 58

warm - IgG, leukeamia (more common) cold - IgM, lymphoma