Flashcards in Hem Onc Deck (231)
Loading flashcards...
1
Manifestation of initial seroconversion of HIV
Mono type syndrome with fever, malaise, pharyngitis, rash, lymphadenopathy
Neonate: oral thrush, FTT< lymphadenopathy.
2
Dx HIV
ELISA confirmed with Western
3
When to start retrovirals for HIV
CD 4<350
Pregnant
Nephropathy
Hep B conifection
4
CD 4< 200 prophy
PCP: TMP-SMX, daponse, or pentamidine
5
CD4<50 prophy
MAC: Azithromycin or Clarithromycin/ or Rifabutin as alternative
Consider cryptococcal and candida prophy with fluconazole
6
Vaccine must give with CD 4 >200
MMR - because is live
7
Vaccine to give to all HIV pts
Pneumo
Hep B
Inactivated polio
Annual flu
Tetanus booster q 10 yrs
Annual PPD, CXR if anergic
8
AIDS associated malignancies
Kaposi - HHV 8
nonHogkin lymphpma (esp primary B cell of CNS)
9
Positive India Ink
Cryptococcus
10
Ring enhancing lesion
Toxoplasmosis
Cysticerosis/Taenia solium in Latin America
11
Meds to reduce mom-child transmission HIV
Mom: AZT/ZDV, no breastfeeding
Kid: ZDV for 6 weeks after birth
12
CMV retinitis Tx
Valganciclovir
Alt: foscarnet or cidofovir
13
Stains to detect PCP
Silver - Wright Giemsa, Giemsa, methanemine silver
14
Needle stick - what to do
HIV testing
Start HAART immediately - lamivudine, zidovudine
Restest 6 wks, 3 months, 6 months
15
Four causes microcytic anemia
TICS-
Thalessemia
Iron def
anemia of Chronic disease
Sideroblastic anemia
16
Elderly man with hypochromic microcytic anemia and no Sx, Dx test?
FOBT and sigmoidoscopy
Suspect colorectal Ca
17
Precipitants of hemolytic crisis in pts with G6PD def
Sulfonamides
Antimlalarial Rx
Fava beans
18
Most common inherited cause of hypercoagulability
Factor V Leiden
19
Most common inherited bleeding disorder
von Wilebrand's
20
Most common inherited hemolytic anemia
Hereditary spherocytosis
21
Dx test for hereditary spherocytosis
Osmotic fragility test
22
Pure RBC aplasia
Diamond Blackfan anemia
23
Anemia associated with absent radii and thumbs, diffuse hyper-pigmentation, cafe au lait, microcephaly, pancytopenia
Fanconi's
24
Meds and viruses that lead to aplastic anemia
Chloramphenicol, sulfonamides, radiation, chemo
Hepatitis, HIV, Parvovirus B19, EBV
25
How to distinguish polycythemia vera from secondary polycythemia
Both have inc HCT and RBC mass
Polycythemia vera: normal O2 sats and low EPO
26
TTP pentad
FAT RN
Fever
Anemia
Thrombocytopenia
Renal dysfunction
Neuro abnormalities
ADAMTS13
27
HUS triad
Anemia
Thrombocytopenia
Acute renal failure
28
Tx TTP
Emergent large volume plasmapheresis
Corticosteroids
Antiplatelet drugs
NO PLATELET TRANSFUSION - CI!!!!
29
Tx ITP in children
Resolves spontaneously, may require IVIG and/or corticosteroids
30
