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Flashcards in Hem Onc Deck (231)
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1

Manifestation of initial seroconversion of HIV

Mono type syndrome with fever, malaise, pharyngitis, rash, lymphadenopathy

Neonate: oral thrush, FTT< lymphadenopathy.

2

Dx HIV

ELISA confirmed with Western

3

When to start retrovirals for HIV

CD 4<350
Pregnant
Nephropathy
Hep B conifection

4

CD 4< 200 prophy

PCP: TMP-SMX, daponse, or pentamidine

5

CD4<50 prophy

MAC: Azithromycin or Clarithromycin/ or Rifabutin as alternative

Consider cryptococcal and candida prophy with fluconazole

6

Vaccine must give with CD 4 >200

MMR - because is live

7

Vaccine to give to all HIV pts

Pneumo
Hep B
Inactivated polio
Annual flu
Tetanus booster q 10 yrs
Annual PPD, CXR if anergic

8

AIDS associated malignancies

Kaposi - HHV 8
nonHogkin lymphpma (esp primary B cell of CNS)

9

Positive India Ink

Cryptococcus

10

Ring enhancing lesion

Toxoplasmosis
Cysticerosis/Taenia solium in Latin America

11

Meds to reduce mom-child transmission HIV

Mom: AZT/ZDV, no breastfeeding
Kid: ZDV for 6 weeks after birth

12

CMV retinitis Tx

Valganciclovir
Alt: foscarnet or cidofovir

13

Stains to detect PCP

Silver - Wright Giemsa, Giemsa, methanemine silver

14

Needle stick - what to do

HIV testing
Start HAART immediately - lamivudine, zidovudine
Restest 6 wks, 3 months, 6 months

15

Four causes microcytic anemia

TICS-
Thalessemia
Iron def
anemia of Chronic disease
Sideroblastic anemia

16

Elderly man with hypochromic microcytic anemia and no Sx, Dx test?

FOBT and sigmoidoscopy
Suspect colorectal Ca

17

Precipitants of hemolytic crisis in pts with G6PD def

Sulfonamides
Antimlalarial Rx
Fava beans

18

Most common inherited cause of hypercoagulability

Factor V Leiden

19

Most common inherited bleeding disorder

von Wilebrand's

20

Most common inherited hemolytic anemia

Hereditary spherocytosis

21

Dx test for hereditary spherocytosis

Osmotic fragility test

22

Pure RBC aplasia

Diamond Blackfan anemia

23

Anemia associated with absent radii and thumbs, diffuse hyper-pigmentation, cafe au lait, microcephaly, pancytopenia

Fanconi's

24

Meds and viruses that lead to aplastic anemia

Chloramphenicol, sulfonamides, radiation, chemo
Hepatitis, HIV, Parvovirus B19, EBV

25

How to distinguish polycythemia vera from secondary polycythemia

Both have inc HCT and RBC mass
Polycythemia vera: normal O2 sats and low EPO

26

TTP pentad

FAT RN
Fever
Anemia
Thrombocytopenia
Renal dysfunction
Neuro abnormalities

ADAMTS13

27

HUS triad

Anemia
Thrombocytopenia
Acute renal failure

28

Tx TTP

Emergent large volume plasmapheresis
Corticosteroids
Antiplatelet drugs
NO PLATELET TRANSFUSION - CI!!!!

29

Tx ITP in children

Resolves spontaneously, may require IVIG and/or corticosteroids

30

Which of following are inc in DIC, fibrin split products, D-dimer, fibrinogen, plts, HCT

Inc: fibrin split and D- dimer
Dec: plts, fibrinogen, Hct