Hema 2 Lec M1.2

Question 1

In the FAB Classification of AML, what type of AML is related to Disseminated Intravascular Coagulation?

Answer 1

M3

Question 2

In FAB classification of AML, what classification does granules starts to appear?

Answer 2

M1

Question 3

Other name for Polycythemia Vera?

Answer 3

Osler’s Disease

Question 4

What mutation is usually present in 3% of patients with osler’s disease?

Answer 4

JAK2 Exon 12

Question 5

Essential Thrombocythemia is also known as ____

Answer 5

Idiopathic thrombocytosis, hemorrhagic thrombocythemia, & Primary thrombocytosis

Question 6

Term for Hematopoietic Stem Cell transplantation where your donor is from your identical twin.

Answer 6

Syngeneic

Question 7

In malignant leukocyte disorders, what type of malignant cell is more common?

Answer 7

Lymphoma or sarcoma

Question 8

Blast cells or immature cells are the predominant cell type in this Leukemia (Acute or Chronic)

Answer 8

Acute Leukemia

Question 9

True or False

Presence of blast in the PBS is common

Answer 9

FALSE

Sa bone marrow lang siya makikita

Question 10

What is the expected LAP Score of a patient suffering from Chronic Myelogenous Leukemia?

Answer 10

< 15 LAP Score

Question 11

Philadelphia Chromosome is usually detected in this kind of leukemia

Answer 11

Chronic Myelogenous Leukemia

Question 12

Chronic Myelogenous Leukemia usually has a mutation or translocarion between ___

Answer 12

t(9:22)(q34;q11) or BCR-ABL

Question 13

From BM, systemic - Myeloproliferative disorders

Answer 13

Leukemia

Question 14

From lymphoid tissue, localized- lymphoproliferative disorders

Answer 14

Lymphoma or Sarcoma

Question 15

Myeloproliferative disorders involves CFU-GEMM which are

Answer 15

Granulocytes
Erythrocytes
Monocytes
Macrophage

Question 16

What interleukin is involved in lymphoproliferative disorders?

Answer 16

IL-7

Question 17

Give me the 4 etiology of Leukemia

Answer 17

-Genetic Susceptibility
-Viral Infection
-Somatic Mutation
-Immunologic Dysfunction

Question 18

Predominant cell type of Acute Leukemia

Answer 18

Precursor Cell (Immature) or Blast

Question 19

Predominant cell type of Chronic Leukemia

Answer 19

Mature

Question 20

WBC Count of Acute Leukemia

Answer 20

Variable

Question 21

WBC count of Chronic Leukemia

Answer 21

Increased

Question 22

what is the difference of the progression without treatment between acute leukemia and chronic leukemia?

Answer 22

Acute leukemia is rapid progression (weeks to months) while chronic leukemia is slower (months to years)

Question 23

4 Laboratory diagnosis of Neoplasm

Answer 23

-Cytochemical Analysis
-Immunologic analysis
-Chromosomal or genetic analysis
-DNA analytical assay

Question 24

What is the chemical stain result of Acute Myeloid Leukemia with Myeloperoxidase and Sudan Black B

Answer 24

Positive

Question 25

What is the chemical stain result of Acute Lymphocytic Leukemia with Myeloperoxidase and Sudan Black B

Answer 25

Negative

Question 26

True or False L1 & L2 of ALL are positive to TDT and negative or PAS

Answer 26

True

Question 27

General Categories of therapy for Hematologic Neoplasms

Answer 27

-Chemotherapy -Radiation Therapy -Supportive Therapy -Targeted Therapy -Hematopoietic Stem Cell Transplantation

Question 28

The Main glycoprotein hormone for RBC

Answer 28

Erythropoietin (EPO)

Question 29

Hematopoietic stem cell transplantation in other living species

Answer 29

Syngeneic

Question 30

Hematopoietic stem cell transplantation in same species

Answer 30

Allogeneic

Question 31

Hematopoietic stem cell transplantation in identical twin donor

Answer 31

Autologous

Question 32

Criterion for diagnosis of AML is the presence of 30% blasts

Answer 32

French-American-British (FAB)

Question 33

Criterion AML is the presence of 20% blasts and is more specific

Answer 33

World Health Organization (WHO)

Question 34

This refers to all myeloid cells are increased

Answer 34

Panmyelosis

Question 35

Results in increased apoptosis and has ineffective hematopoiesis

Answer 35

Myelodysplastic Sydnromes