Tumor Markers CC Lec Flashcards by Ellyza Msc

Q

TM: Prostate-Specific Antigen

A

CA: Prostate CA

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Q

TM: LD

A

CA: Hematologic Malignancies

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Q

Liver: Metastatic Bone CA & Hepatocellular CA

A

TM: ALP

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Q

Bone: Osteocarcoma

A

TM: ALP

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Q

TM: Neuron-Specific Enolase

A

CA: Neuroendocrine Tumors

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Q

TM: Serum M-Protein

A

CA: Plasma cell dyscrasias

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Q

TM: Serum Free Light Chains

A

CA: Plasma cell dyscrasias

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Q

TM: Beta 2-Microglobulin

A

CA: Hematologic Malignancies

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Q

TM: ACTH

A

CA: Pituitary Adenoma & Ectopic ACTH

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Q

TM: AVP

A

CA: Posterior Pit. Tumor

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Q

TM: C-Peptide

A

CA: Insulin-secreting tumor

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Q

TM: Calcitonin

A

CA: Medullary Thyroid Carcinoma

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Q

TM: Chromogranin A

A

Catecholamines

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Q

CA-125

A

Ovarian cancer

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Q

CA 15-3

A

Metastatic Breast Cancer

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Q

CA 19-9

A

Pancreatic cancer
GIT cancer
Adenocarcinoma

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Q

CA 27-29

A

Metastatic Breast Carcinoma

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Q

Grain Alcohol

A

Ethanol

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Q

Diuresis & Acidosis

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A

Ethanol

Q

Wood Alcohol

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A

Methanol

Q

Forms formic acdi

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A

Methanol

Q

Causes blindness:

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A

Methanol

Q

Rubbing Alcohol

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A

Isopropanyl

Q

Accumulation of acetone

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A

Isopropanyl

Antidote: Active Charcoal

Isopropanyl

1. Found in hydraulic fluid and antifreeze substances 2. Sweet taste and smell

Ethylene Glycol

Antidote: Diazepam/Valium

Ethanol

Metabolite: Formaldehyde Product: Formic Acid

Methanol

Metabolite: Oxalic acid & Glycolic acid

Ethylene Glycol

Odorless, tasteless, colorless Major toxic effect: Hypoxia

Carbon Monoxide

Cherry red color of face

Carbon Monoxide

Bitter almond odor

Cyanide

Most common configuration of pesticides:

Organophosphates

Inhibits: acetylcholinesterase

Organophosphates

Screening: Serum ChE

Pesticides

Pesticides confirmatory test:

Erythrocytic ChE/ChE in RBCs

Garlic odor and mettalic taste

Arsenic

Inhibits: sulfhydryl enzymes

Arsenic

Reinsch Test

Arsenic

Best specimen: Nails and skin

Arsenic

Electroplating and galvanizing

Cadmium

Destroys type 1 epithelial cells in lungs

Cadmium

Blocks: 1. Dela aminolevulinic acid synthase 2. Pyrimidine 5' nucleotidase 3. Na-K ATPase

Lead

Specimen: first morning urine

Lead

Inhibits: COMT

Mercury