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Oral Pathology > Hematologic > Flashcards

Hematologic Flashcards

1
Q

Increase in the number if circulating WBCs to more than 11k in adults

A

Leukocytosis

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2
Q

Reduction in the number of circulating WBCs to less than 4400

A

Leukopenia

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3
Q

Leukopenia can be manifested in

A

Agranulocytosis
Pancytopenia
Chemotherapeutic drugs

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4
Q

Malignancies arise from hematopoietic stem cells in the bone marrow

A

Leukemia

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5
Q

Classify leukemia

A

Histogenesis:
myeloid
Lymphocytic

Clinical behaviour:
Acute
Chronic

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6
Q

Malignacy of Myeloid immature WBCs occuring in adults 50yrs of age sudden onset

A

Acute myelogenous leukemia AML

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7
Q

Crystalline elongated intracytoplasmic acidophillic bodies present in malignant myeloblasts

A

Auer rods

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8
Q

Uncontrolled proliferation of immature LYMPHOID cells in the bone marrow of children

A

Acute Lymphocytic Leukemia ALL

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9
Q

Malignancy of nature B lymphocytes in adults
Least malignant type

A

Chronic lymphocytic leukemia CLL

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10
Q

Neoplasm of mature myeloid white blood cells

A

Chronic myeloid leukemia CML

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11
Q

Translocation of the chromosomal material between 9 and 22

A

Philadelephia chromosome that results in uncontrolled proliferation of abnormal immature leukemic cells

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12
Q

Diffuse non tender swelling may or may not be ulcerated results in DIFFUSE GINGIVAL ENLARGEMENT

A

Myeloid luekemia - send patient for blood work to confirm the diagnosis because biopsy wont help

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13
Q

Deficiency in erythrocytes

A

Fatigue
Shortness of breath
Oral pallor

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14
Q

Deficiency of platelets

A

Easy bruising bleeding
Spont gingival bleeding
Petechial hemorrhage of the post hard palate and soft palate
Internal bleeding

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15
Q

Deficiency of luekocytes

A

Ulcerations on gingiva most committed and the palate GRAYISH WHITE NECROTIC BASE

Oral candidiasis
Viral infections like HERPES simplex

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16
Q

Condition where the cells from the granulocytic series mainly neutrophils are absent

A

Agranulocytosis

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17
Q

Which drugs can cause agranulocytosis

A

Antithyroid drugs
Methinazkle
Propylthiouracul
Carbimazole

18
Q

Oral manifestations of agranulocytosis

A

Deep necrotizing punched out ulcers on buccal mucosa
Tongue
Palate and gingiva

19
Q

Filgrastim

A

Granulocyte stimulating factor prescribed for patients who undergo chemo to recover from low granulocyte counts

20
Q

Idiopathic didorder caused by a regular periodic reduction in the neutrophil population usually every 22 days

A

Cyclic neutropenia

21
Q

Oral manifestations of cyclic neutropenia

A

Severe periodontal bone loss with gingival recession and tooth mobility

22
Q

Hypochromic and microcytic

A

Iron deficiency
Thalassemia

23
Q

Hemolytic anemia

A

Glucose 6 phosphate dehydrogenase deficiency
Erythtroblastosis fetalis
Sickle cell anemia

24
Q

Megaloblastic anemia

A

Vit b 12
Folate def

25
Q

Most commonest cause of anemia

A

Iron deficiency anemai

26
Q

Oral manifestations of iron deficiency anemia

A

Angular cheilitis - inflammation erthyma fissuring and scaling of corners of the mouth
Glossitis - diffuse or patchy atrophy of the dorsal papillae of the tongue
Burning sensation
Tongue is pale

27
Q

Syndrome that combines iron deficiency anemia with glossitis dysphagia and koilonychias - spoon shaped brittle nails
Angular cheilitis burning sensau

A

Plummer vinson syndrome

28
Q

Syndrome associated with an increased in oral and esophageal SCC intraorally

A

Plummer vinson syndrome

29
Q

Megaloblastic anemia caused by poor intestinal absorption of vit B12 because of lack of intrinsic factor

A

Pernicious anemia

30
Q

Oral symptoms of megaloblastic / pernicious anemia

A

Parasthesia
Tingling
Numbness
Atrophic glossitis - HUNTER GLOSSITIS
Burning sensation of tongue lip buccal mucosa

31
Q

Failure of the hematopoietic precursor cells in the bone marrow to produce adequate number of RBCs WBCs and platelets

A

Aplastic anemia

32
Q

Oral manifestations of aplastic anemia

A

Ulcerations
Pale oral mucosa
Gingival hemorrhage
Mucosal petechiae
Purpura
Ecchymoses
Fatigue
Light headedness
Tachycardia weakness
Burising bleeding
Infections

33
Q

Severe genetic disorder of hemoglobin synthesis

A

Sickle cell anemia

34
Q

Abnormal hemoglobin S is formed which results un the change if RBC from disc to sickle

A

Sickle cell anemia

35
Q

Hair on end appearance can be seen on lateral skull radiograph

A

Sickle cell anemia
Deposition direction is perpendicular to the normal bone

36
Q

Cooleys anemia or mediterranean anemia also known as

A

Thalassemia

37
Q

Inherited disorders characterized by the abnormal formation of either aloha or beta globin chains of hemoglobin

A

Thalassemia

38
Q

Painless enlargement of mandible and maxilla due to bone marrow hyperplasia
Chipmunk app due to reduction in size or obliteration of paranasal sinuses
Frontal bossing and flaring of max teeth
Delayed dental development
Hair on end

A

Thalassemia

39
Q

Hemolytic anemia of newborns secondary to a blood incompatibility between the mother and fetus

A

Erythroblastosis fetalis

40
Q

Intrinsic staining of teeth - green blue yellow due to excess bilirubin which may accumulate in the developing teeth of primary dentition and cusps of permanent first molars

A

Erythtroblastosis fetalis

41
Q

Idiopathic hematological disorders in which there are too many functioning RBCs

A

Polycythemia

42
Q

Spontaneous gingival bleeding
Prolonged bleeding after certain dental procedures
Petechie purpura echhymoses on the palate

A

Thrombocytopenia

Oral Pathology (16 decks)

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