Hematologic

Question 1

Increase in the number if circulating WBCs to more than 11k in adults

Answer 1

Leukocytosis

Question 2

Reduction in the number of circulating WBCs to less than 4400

Answer 2

Leukopenia

Question 3

Leukopenia can be manifested in

Answer 3

Agranulocytosis
Pancytopenia
Chemotherapeutic drugs

Question 4

Malignancies arise from hematopoietic stem cells in the bone marrow

Answer 4

Leukemia

Question 5

Classify leukemia

Answer 5

Histogenesis:
myeloid
Lymphocytic

Clinical behaviour:
Acute
Chronic

Question 6

Malignacy of Myeloid immature WBCs occuring in adults 50yrs of age sudden onset

Answer 6

Acute myelogenous leukemia AML

Question 7

Crystalline elongated intracytoplasmic acidophillic bodies present in malignant myeloblasts

Answer 7

Auer rods

Question 8

Uncontrolled proliferation of immature LYMPHOID cells in the bone marrow of children

Answer 8

Acute Lymphocytic Leukemia ALL

Question 9

Malignancy of nature B lymphocytes in adults
Least malignant type

Answer 9

Chronic lymphocytic leukemia CLL

Question 10

Neoplasm of mature myeloid white blood cells

Answer 10

Chronic myeloid leukemia CML

Question 11

Translocation of the chromosomal material between 9 and 22

Answer 11

Philadelephia chromosome that results in uncontrolled proliferation of abnormal immature leukemic cells

Question 12

Diffuse non tender swelling may or may not be ulcerated results in DIFFUSE GINGIVAL ENLARGEMENT

Answer 12

Myeloid luekemia - send patient for blood work to confirm the diagnosis because biopsy wont help

Question 13

Deficiency in erythrocytes

Answer 13

Fatigue
Shortness of breath
Oral pallor

Question 14

Deficiency of platelets

Answer 14

Easy bruising bleeding
Spont gingival bleeding
Petechial hemorrhage of the post hard palate and soft palate
Internal bleeding

Question 15

Deficiency of luekocytes

Answer 15

Ulcerations on gingiva most committed and the palate GRAYISH WHITE NECROTIC BASE

Oral candidiasis
Viral infections like HERPES simplex

Question 16

Condition where the cells from the granulocytic series mainly neutrophils are absent

Answer 16

Agranulocytosis

Question 17

Which drugs can cause agranulocytosis

Answer 17

Antithyroid drugs
Methinazkle
Propylthiouracul
Carbimazole

Question 18

Oral manifestations of agranulocytosis

Answer 18

Deep necrotizing punched out ulcers on buccal mucosa
Tongue
Palate and gingiva

Question 19

Filgrastim

Answer 19

Granulocyte stimulating factor prescribed for patients who undergo chemo to recover from low granulocyte counts

Question 20

Idiopathic didorder caused by a regular periodic reduction in the neutrophil population usually every 22 days

Answer 20

Cyclic neutropenia

Question 21

Oral manifestations of cyclic neutropenia

Answer 21

Severe periodontal bone loss with gingival recession and tooth mobility

Question 22

Hypochromic and microcytic

Answer 22

Iron deficiency
Thalassemia

Question 23

Hemolytic anemia

Answer 23

Glucose 6 phosphate dehydrogenase deficiency
Erythtroblastosis fetalis
Sickle cell anemia

Question 24

Megaloblastic anemia

Answer 24

Vit b 12
Folate def

Question 25

Most commonest cause of anemia

Answer 25

Iron deficiency anemai

Question 26

Oral manifestations of iron deficiency anemia

Answer 26

Angular cheilitis - inflammation erthyma fissuring and scaling of corners of the mouth Glossitis - diffuse or patchy atrophy of the dorsal papillae of the tongue Burning sensation Tongue is pale

Question 27

Syndrome that combines iron deficiency anemia with glossitis dysphagia and koilonychias - spoon shaped brittle nails Angular cheilitis burning sensau

Answer 27

Plummer vinson syndrome

Question 28

Syndrome associated with an increased in oral and esophageal SCC intraorally

Answer 28

Plummer vinson syndrome

Question 29

Megaloblastic anemia caused by poor intestinal absorption of vit B12 because of lack of intrinsic factor

Answer 29

Pernicious anemia

Question 30

Oral symptoms of megaloblastic / pernicious anemia

Answer 30

Parasthesia Tingling Numbness Atrophic glossitis - HUNTER GLOSSITIS Burning sensation of tongue lip buccal mucosa

Question 31

Failure of the hematopoietic precursor cells in the bone marrow to produce adequate number of RBCs WBCs and platelets

Answer 31

Aplastic anemia

Question 32

Oral manifestations of aplastic anemia

Answer 32

Ulcerations Pale oral mucosa Gingival hemorrhage Mucosal petechiae Purpura Ecchymoses Fatigue Light headedness Tachycardia weakness Burising bleeding Infections

Question 33

Severe genetic disorder of hemoglobin synthesis

Answer 33

Sickle cell anemia

Question 34

Abnormal hemoglobin S is formed which results un the change if RBC from disc to sickle

Answer 34

Sickle cell anemia

Question 35

Hair on end appearance can be seen on lateral skull radiograph

Answer 35

Sickle cell anemia Deposition direction is perpendicular to the normal bone

Question 36

Cooleys anemia or mediterranean anemia also known as

Answer 36

Thalassemia

Question 37

Inherited disorders characterized by the abnormal formation of either aloha or beta globin chains of hemoglobin

Answer 37

Thalassemia

Question 38

Painless enlargement of mandible and maxilla due to bone marrow hyperplasia Chipmunk app due to reduction in size or obliteration of paranasal sinuses Frontal bossing and flaring of max teeth Delayed dental development Hair on end

Answer 38

Thalassemia

Question 39

Hemolytic anemia of newborns secondary to a blood incompatibility between the mother and fetus

Answer 39

Erythroblastosis fetalis

Question 40

Intrinsic staining of teeth - green blue yellow due to excess bilirubin which may accumulate in the developing teeth of primary dentition and cusps of permanent first molars

Answer 40

Erythtroblastosis fetalis

Question 41

Idiopathic hematological disorders in which there are too many functioning RBCs

Answer 41

Polycythemia

Question 42

Spontaneous gingival bleeding Prolonged bleeding after certain dental procedures Petechie purpura echhymoses on the palate

Answer 42

Thrombocytopenia