Vesiculobullous Disease Flashcards
Infections that have vesicullbullous presentations
Herpes simplex primary and secondary
Varicella zoster
Chicken pox
Shingles
Coxsackie virus
Herpangina
Hand foot mouth disease
Immunilogic diseases manifests as vesiculo bullous lesions
Pemphigus vulgaris
Mucous membrane pemphigoid
Erythma multiforme
Stevenson johnson syndrome
Features of acute herpetic gingivistomatis
6months to 5years old chikdren and young adults
Subclinical
Pinhead vesicles rapidly collapse to form numerous lesions
Keratinised mucosa
Most common site of recurrence for HSV 1
Vermillion border and adjacent skin of the lips
Intraoral mucosal site for herpes recurrent infections
Hard palate and attached gingiva
Microscopic features of HSV 1 infection
Ballooning degeneration
Acantholysis
Nuclear clearing and enlargement
Tzank cells - acantholytic cells
Lipschutz bodies
Aggregates of cytoplasmic or nuclear substance giving epithelial cells dark colour
Lipschutz bodies in HSV 1
Varicella zoster is caused by
Human herpes virus 3
Features of chicken pox VARICELLA
fever chills malaise pharyngitis and headache
Pruritic vesicular rash on face and trunk then extremities - pustules and scabbing
Oral lesions on palate and buccal mucosa
Complications of varicella
Pneumonitis
Encephalitis
Prodormal stage of herpes zoster
Neural necrosis due to viral replication-severe neuralgia
Acute phase of herpes zoster
Clusters of vesicles on skin and mucosa
Ulcerate within 3-4 days
Persistent pain for 1-3 months after resolution of shingles rash affecting older age females commonly having history of prodormal pain, rash and ophthalmic involvement
Post herpetic neuralgia
Cutaneous lesions of the EAC, ispsilateral facial and auditory nerves involvement, facial paralysis hearing deficits and vertigo
Ramsay hunt syndrome
