Hematologic Malignancies IV Flashcards Preview

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Flashcards in Hematologic Malignancies IV Deck (64)
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61

What is refractory anemia with excess blasts?

5% - 9% morphologic blasts (RAEB-1)
10% - 19% morphologic blasts (RAEB-2)

About half show nonspecific cytogenetic abnormalities

62

Clinical presentation of refractory anemia with excess blasts?

cytopenia
usually in 65+ y/o

63

Immunophenotype in refractory anemia with excess blasts?

blast population (CD34+, and/or CD117+) usually evident

64

Prognosis in refractory anemia with excess blasts?

RAEB-1: 25% progress to AML
RAEB-2: 33% do so.

called "pre-leukemia"

Our diagnostic and management capabilities in these cases are primitive. If we had a better molecular understanding of their pathogenesis we might be able to distinguish those that are likely to progress to AML from those that are not. We’re close, but not quite there.