Hematopoiesis Flashcards Preview

Heme/Lymph > Hematopoiesis > Flashcards

Flashcards in Hematopoiesis Deck (16):
1

Multipotent CSF

Stem cell factor (SCF) binds c-Kit --> all myeloid & lymphoid CFUs

2

Unipotent CSFs

Erythropoietin --> CFU-E (erythropoiesis)
Thrombopoietin --> CFU-Meg (thrombopoiesis)
G-CSF --> CFU-G (neutrophils)
M-CSF --> monocyte --> macrophage

3

What are the 4 criteria that cells fit as they develop?

1. Cell size -- gets smaller
2. Nuclear morphology
3. Cytoplasm: changes from blue --> red
blue = RNA; red = protein
4. Specific granules

4

WBC Diff
% Neutrophils

34-71%

5

WBC Diff
% Lymphocytes

19-53%

6

WBC Diff
% Monocytes

5-12%

7

WBC Diff
% Eosinophils

0-7%

8

WBC Diff
% Basophils

0-1%

9

CBC normal values
WBC

4000 - 10,000 /uL

10

CBC normal values
RBC

4,600,000-6,100,000 /uL
4.6 - 6.1x10^6 /uL

11

CBC normal values
HGB

13.7-17.5 g/dL

12

CBC normal values
HCT

40-51%

13

CBC normal values
MCV

80-100 fL

14

CBC normal values
Platelets

163,000 - 369,000 /uL

15

Which myelocytes are CD45 negative?

Erythroid
Megakaryocytes

16

Which myelocytes are CD45 positive?

Granulocyte
Monocytes