Flashcards in Transfusion Medicine Deck (20):
What infectious diseases are tested for with blood donation?
Hep B, Hep c, HIV, HTLV, Syphilis, West Nile, Trypanosoma cruzi
What does the indirect antiglobulin test detect?
Antibodies in the patient's serum
Function of cell preservatives -- citrate
Anticoagulant, binds Ca2+
Function of cell preservatives--phosphate
Maintains 2,3 DPG levels
Function of cell preservatives--dextrose
For cell metabolism
Function of cell preservatives--adenine
For ADP/ATP production
How much does 1 unit of pRBC's raise the hemoglobin?
1 g/dL in an average sized adult
When is transfusion for anemia supported?
<6 g/dL -- but must take into consideration the patients entire presentation
When giving pRBC's which ABO type is the universal donor? universal acceptor?
What does 1 unit of Fresh Frozen Plasma do for a patient?
10-15 mL raises all clotting factors by 20-30% in average sized adult
When giving FFP which ABO type is the universal donor? universal acceptor?
Universal Donor--AB (no antibodies)
Universal Acceptor--O (Both antibodies)
How much does 1 unit of platelets raise the platelet count?
30,000-60,000 for the average sized adult
What is the first thing to use for DIC?
Cryoprecipitate -- it contains fibrinogen (and factors VIII, XIII, vWF)
What is Febrile Non-hemolytic transfusion reaction (FNHTR)? How do you differentiate between that and Hemolytic transfusion reaction?
Antibodies in recipient against donor WBC's
Patients may have similar symptoms (Chills/backpain/fever_ but hemolytic reaction will show +DAT, hemoglobinuria, increased bilirubin, decreased haptoglobin and increase LDH
What can be given for rigors?
What is especially important in a case of hemolytic transfusion reaction?
Promote adequate renal blood flow (keep urine output >100 mL/hour with IVF and IV diuretics)
What is the #1 cause of death with transfusion?
TRALI = Transfusion related acute lung injury
Patients are SOB, have pulmonary edema, hypotension, fever, tachycardia
What are the three reactions to transfusion that may cause SOB?
TACO = Transfusion associated circulatory overload
Is a person hypertensive or hypotensive with TACO?
Will also have an enlarged heart on CXR?