Flashcards in Plasma Cell Dyscrasias Deck (10):
Most common plasma cell neoplasm
Diagnostic criteria for multiple myeloma.
1. Clonal plasma cells -- bm, plasmacytoma
2. M protein -- Serum and/or urine, intact immunoglobulin OR Bence Jones proteins
3. End organ damage -- CRAB --> hypercalcemia, renal insufficiency, anemia, bone disease
Why is it important to obtain BOTH electrophoresis on the serum and urine for diagnosis of myeloma?
99% of myelomas have an M protein and/or Bence Jones protein
60-70% have serum M protein and Bence Jones proteins
20% have only Bence Jones proteins
What is the most common cause of death in multiple myeloma?
Bacterial infection d/t immunosuppression -- production of normal Igs suppressed with M protein, leading to recurrent infections
Localized growth of monoclonal plasma cells
May be seen in multiple myeloma or as a distinct entity
Most common location for extramedullary plasmacytoma
80% occur in the URT
Lymphoma with plasmacytic differentiation (B cells and plasma cells are neoplastic)
B cell lymphoa with monoclonal IgM production
Cryoglobulinemia -- Raynaud's, Bleeding
< 3 g/dL serum M protein
< 10% clonal plasma cells in BM
No myeloma-related end organ damage
MGUS (monoclonal gammopathy of undetermined significance)