Plasma Cell Dyscrasias Flashcards Preview

Heme/Lymph > Plasma Cell Dyscrasias > Flashcards

Flashcards in Plasma Cell Dyscrasias Deck (10):
1

Most common plasma cell neoplasm

Multiple myeloma

2

Diagnostic criteria for multiple myeloma.

1. Clonal plasma cells -- bm, plasmacytoma
2. M protein -- Serum and/or urine, intact immunoglobulin OR Bence Jones proteins
3. End organ damage -- CRAB --> hypercalcemia, renal insufficiency, anemia, bone disease

3

Why is it important to obtain BOTH electrophoresis on the serum and urine for diagnosis of myeloma?

99% of myelomas have an M protein and/or Bence Jones protein
60-70% have serum M protein and Bence Jones proteins
20% have only Bence Jones proteins

4

What is the most common cause of death in multiple myeloma?

Bacterial infection d/t immunosuppression -- production of normal Igs suppressed with M protein, leading to recurrent infections

5

Localized growth of monoclonal plasma cells
May be seen in multiple myeloma or as a distinct entity

Plasmacytomas

6

Most common location for extramedullary plasmacytoma

80% occur in the URT

7

Lymphoma with plasmacytic differentiation (B cells and plasma cells are neoplastic)
B cell lymphoa with monoclonal IgM production

Lymphoplasmacytic lymphoma

8

Waldenstrom's macroglobulinemia

Visual/neurlogic impariemnt
Cryoglobulinemia -- Raynaud's, Bleeding

9

< 3 g/dL serum M protein
< 10% clonal plasma cells in BM
No myeloma-related end organ damage

MGUS (monoclonal gammopathy of undetermined significance)

10

What percentage of MGUS develops to malignant transformation over 10-20 years?

25%

Generally multiple myeloma >>> Lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia > Primary amyloidosis