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Flashcards in LAD Deck (14):
1

Where B cells are located in the lymph node?

Outer cortex
Germinal follicles

2

Where macrophages and plasma cells are in a lymph node?

Medulla

3

Where T cells are in a lymph node?

Paracortex (between cortex and medulla)

4

3 histological patterns of reactive lymphadenopathy

Follicular hyperplasia-- autoimmune, early HIV, toxoplasmosis
Paracortical hyperplasia-- EBV, CMV, herpes, drugs
Sinus histiocytosis-- draining tumors

5

Follicular lymphoma is generally indolent but 40% may transform to which aggressive lymphomas?

Diffuse large B-cell lymphoma
Burkitt lymphoma

6

How does immunophenotype contribute to diagnosing B-cell NHL?

Establish B-cell lineage
Small-sized lymphomas: CD5, CD10, CD23

7

High grade lymphomas

Burkitt lymphoma
Diffuse large B-cell lymphoma

8

Indolent
Small-sized cells
Mainly MALT sites (gastric, thyroid, lung)
Treatment: antibiotics, resection, radiation, chemo

Extranodal marginal zone lymphoma

9

Agressive
Large-sized cells
Extranodal and nodal disease
Treatment is aggressive chemo

Diffuse large B-cell lymphoma

10

Peidatric tumor
CD8+ T cell neoplasm
Characterized by ALK rearrangements, commonly t(2;5)
Agressive

Anaplastic large-cell lymphoma

11

Adult tumor
Mostly NK-cell neoplasm but may be T cell
Nasal mass with necrosis, extransive destruction and angioinvasion
Agressive

Extranodal NK/T-cell lymphoma
Nasal type

12

What are the clinical variants of Burkitt lymphoma?

Sporatic (ileocecal mass)
Endemic (EBV, breast, jaw, ovary mass)
Immunosuppression-related (EBV)
Transformation from follicular lymphoma

13

EBV-associated neoplasms

Lymphomas (mostly B): Endemic Burkitt, Post-transplant Lymphoproliferative disorder, Extranodal NK/T-cell lymphoma, nasal type; Subsets of Hodgkin lymphoma, diffuse large B-cell lymphoma, T-cell lymphomas
Nasopharyngeal carcinoma

14

What is interesting about classical HL?

It is a B-cell neoplasm but does not express CD20