Flashcards in Intro to Anemia 2 Deck (17):
Mean cell volume
Useful in differential diagnosis of anemia (microcytic, normocytic, and macrocytic)
Mean corpuscular hemoglobin
Average amount of hemoglobin per RBC
Mean corpuscular hemoglobin concentration
Measure of "chromicity" of RBCs
Red cell distribution width
Measure of variability of red cell volume
Useful to separate anisocytotic anemias (Fe deficiency) from non-anisocytotic anemias (anemia or chronic disease)
Weakness/malaise, easy fatiguability
Marrow expansion with potential bony abnormalities
Increase RBC production
Shunting of blood to vital areas
Tachycardia; cardiac ischemia (severe)
Dyspnea on exertion
Increased pulmonary function
Anemia of blood loss (acute)
Initially no anemia by CBC despite decreased blood volume
Anemia develops as fluid enters vascular space to restore blood volume --> dilutes cellular elements
Retic count increases after 2-3 days and peaks after 7-10 days
Anemia of blood loss (chronic)
Initially no anemia b/c the bone marrow is able to compensate
Eventually develop Fe deficiency anemia
What is the blue-tinged cytolasm of reticulocytes caused by and what is this called?
What does the reticulocyte % help you differentiate between?
Anemias that have decreased RBC production and those with marrow response to blood loss or increased RBC destruction
What are some examples of pathologic states that have ineffective erythropoiesis?
What are some things that may lead to a decreased RBC production?
Absolute decrease in marrow mass of erythroid precursors
What are some stem cell defects with adequate EPO?
Congenital: Diamond-Blackfan syndrome (pure cell aplasia), Fanconi's anemia (pan-aplastic)
Acquired: idiopathic, drugs, autoimmune, infections