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Flashcards in Hematopoietic GF Webcast Deck (14):
1

What is the function of EPO?

Development of mature RBCs from hematopoietic SCs

2

Where and when is EPO produced?

85% produces w/i the kidneys in response to hypoxia

3

In what conditions is EPO decreased?

Normoxia
Polycythemia

4

What is HIF?

Hypoxia-inducible factor -- regulated by proline hydroxylation

5

What are some uses of recombinant erythropoietin (epoetin alfa, darbopoietin)?

CKD -- can increased hemoglobin, improve survival of kidney failure patients and decrease need for transfusion

Anemia in patients receiving chemo
Anemia assoc with MDS
Anemia assoc with HIV
Anemia in patients who refuse blood transfusions

6

SE of recombinant erythropoietin

Htn
Ha
venous thrombosis
MI/stroke (rare)
Pure red cell aplasia (rare)

7

Function of thrombopoietin (TPO)

Regulator of platelet production
Enhances megakaryocyte proliferation and maturation, platelet production

8

What organ produces TPO?

Liver

9

Explain what happens to TPO in the setting of thrombocytopenia?

TPO levels rise from the absence of platelets
Leads to increased megakaryocyte binding

10

What are some clinical uses of TPO receptor agonists (eltrombopag, romiplostim)??

Treatment of thrombocytopenia
Assoc with decreased need for platelet transfusion
SE include ha, venous thrombosis and myelofibrosis

11

What types of cells produce granulocyte colony stimulating factor??

Monocytes, macrophages, fibroblasts and endothelial cells

12

In what setting does G-CSF levels increase?

In the setting of pro-inflammatory mediators like IL-1 and TNF -- acts to increase the production of neutrophils

13

What are some clinical uses of G-CSF (filgrastim)??

Prevention of infection in patients with chemo-induced neutropenia
Treatment of fevers, infections in patients with neutropenia
HIV assoc neutropenia
Chronic neutropenia syndromes
Mobilization of SCs before autologous BM

14

What are SE of Filgrastim?

Fever
Bone pain (pelvis hips)
Fluid retention and pulmonary edema (rare)