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Flashcards in Heme Onc Deck (27)
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1

Monitor heparin vs warfarin

heparin: PTT (intrinsic via antithromb III)
warfarin: PT (extrinsic via vit K)

2

Hemophelia A, B, C factor deficiencies and tx

A: VIII
B: IX
C: XI
Tx: transfusion of cryoprecipitate (VIII, fibrinogen)
DDAVP for mild (+ fluid restriction)

3

Ristocetin assay

test for vWF, measures ability to agglutinate platelets

4

Deficiencies: Bernard soulier, glanzmann thormbasthenia

Bernard Soulier: GpIb
Glanzmann: GpIIb/IIIa

5

Long term tx of DVT

1st: 3-6mo warfarin
2nd: 6-12 mo
3rd+: lifelong warfarin

6

DIC vs severe liver disease

Factor VIII depressed in DIC

7

3 causes microangiopathic hemolytic anemia

HUS (incr creat)
TTP
DIC (abn clotting, incr PT/PTT/ d-dimer)

8

Tx: TTP vs ITP

TTP: plasmapheresis, plasma replacement, steroids
ITP: corticosteroids, IVIG, splenectomy

9

B12 vs folate deficiency: labs

B12: incr MMA and homocysteine
folate: normal MMA, incr homocysteine

10

cafe au lat spots, short stature, thumb hypoplasia, anemia

fanconi anemia

11

health maintenance for sickle cell

folate suppl, pneumo vax,

12

Tx: acute chest syndrome

hydration, incentive spirometry, sickle variant

13

Tx of polycythemia vera

cytoreductive drugs (eg hydroxyurea, IFN), ASA for prothrombotic

14

How distinguis leukemoid rxn vs leukemia

LAP: high in leukemoid rxn, low in leukemia

15

photodermatitis, neuropsych, colicky abd pain: dx and tx

porphyria
glucose to decr heme synth

16

Auer rod on smear: dx and tx

AML type M3, ATRA

17

WBC >100,000 with TIA/ other blood vessel occlusion: dx and tx

leukostasis
hydroxyurea +/- leukopheresis

18

smudge cells: dx, workup, tx

CLL
CD5+CD20/21+
Tx when symptomatic: chemo, radiation

19

TRAP + staining: dx and tx

hairy cell leukemia
Tx: cladribine (nucleoside analog), IFNa, spelectomy

20

Dx and classification of NHL

excisional bx of LN
# of nodes and sides of diaphragm involved

21

B symptoms, pruritis, hepatosplenomegaly, weekly fevers, alcohol-induced pain: dx and tx, prognostic factors

Hodgkin's disease
excisional LN biopsy: Reed-sternberg cells
Chemo and/or radiation; lymphocyte predominant= best prognosis

22

Anemia, renal failure, bone pain: what must be ruled out, tx

multiple myeloma (>10% plasma cells in BM, M protein, lytic bone lesions)
Tx: melphalan, prednisone

23

Marrow shows dutcher bodies (PAS+ deposits around nucleus)

Waldenstrom's
tx: remove excess Ig with plasmapheresis

24

Common causes sepsis for neutropenia, tx

S. aureus, Psuedomonas, E coli, proteus, klebsiella
tx: cefepime

25

Hematuria and eosinophilia

shcistosomiasis

26

Neoplasms assoc with tuberous sclerosis

astrocytoma
cardiac rhabdomyoma

27

Neoplasm assoc with plummer-vinson

SCC of esophagus