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Flashcards in Hemoglobin Deck (58):
0

Respiratory pigment

Hemoglobin

1

Most functional iron in humans

Hemoglobin
Myoglobin

2

Storage form of iron

Ferritin
Hemosiderin

3

Iron that is incorporated into hemoglobin molecules

Heme

4

Reduced form of iron

Ferrous

5

Best time to take iron supplements

Early morning

6

Transport protein for iron

Transferrin

7

Main component of RBC

Hemoglobin

8

In 1RBC, what is the concentration of hemoglobin?

34g/dL

9

1g of Hb contains (iron)

3.47mg

10

Other term for heme

Protoporphyrin IX

11

Composition of heme

Carbon
Hydrogen
Nitrogen
With ferrous

12

Has four polypeptide chains and each chain is attached to 1heme group

Globin

13

Globin comprises how many amino acids?

141-146

14

Heme synthesis occurs in? In what stage?

Bone marrow
From Pronormoblast to reticulocyte

15

By products of heme synthesis

Delta aminolevulinic acid
Porphobilinogen
Uroporphyrinogen III
Coproporphyrinogen III
Protoporphyrinogen IX
Protoporphyrin IX

16

Chromosome 16

Alpha and zeta

17

Chromosome 11

Beta, delta, gamma, epsilon

18

Production of globin chains take place in what stage

Pronormoblast to reticulocyte

19

Beta globin mRNA is translated more efficiently than?

Alpha globin mRNA

20

Oxygenated hemoglobin

Oxyhemoglobin

21

Oxyhemoglobin color? Seen in?

Arterial blood-bright red

22

Gower I

Zeta and epsilon

23

Portland

Zeta and gamma

24

Gower II

Alpha and epsilon

25

HbA

95% two alpha and two beta

26

HbA2

3-5% two alpha and two delta

27

HbF

1-2% two alpha and two gamma

28

HbF present in few RBC are called?

F cells

29

Formed by post synthetic, nonenzymatic reactions of various sugars with amino groups of the globin chain

HbA1

30

Normal adult hemoglobin

HbA
HbA2
HbF

31

Reference range

Male=14-18g/dL
Female=12-15g/dL
Newborn =16.5-21.5g/dL

32

Deoxygenated hemoglobin color? Seen in?

Venous blood-dark red

33

Hemoglobin with Carbon monoxide

Carboxyhemoglobin

34

Carboxyhemoglobin color?

Cherry red in blood and skin

35

Hemoglobin contains iron in the ferric state

Methemoglobin

36

Exposure to oxidizing agent will result to production of?

Methemoglobin

37

Characteristic of methemoglobin in the blood

Chocolate brown color

38

Treatment of methemoglobin

Administration of ascorbic acid or methylene blue

39

Formed by the irreversible oxidation of Hb by certain drugs and chemical

Sulfhemoglobin

40

In vitro Sulfhemoglobin gives?

Greenish pigment

41

A key rate limiting step in heme synthesis is suppression of

Aminolevulinate synthase

42

Ferric oxidation product of heme

Hemin

43

Amount of oxygen needed to saturate 50% of hemoglobin

P50 value

44

Curve

Sigmoidal

45

How many oxygen is bound by each gram of hemoglobin

1.34mL

46

Shifts of the curve to the left or right occur if there are changes in the pH of the blood

Bohr effect

47

Normal PO2

27mm hg

48

Shifts to the left

Higher oxygen affinity
Lower release of oxygen

49

Shift to the right

Lower oxygen affinity
Higher release of oxygen

50

Its oxygen affinity is 240times and 10000 times slower oxygen release

Carboxyhemoglobin

51

Increase 2,3-BPG

Shift to the right.
Decrease oxygen affinity

52

Lower pH or increase in Hydrogen concentration

Shift to the right
Decrease oxygen affinity

53

Decrease PCO2

Shift to the left
Increase oxygen affinity

54

Increase in temperature

Shift to the right
Decrease oxygen affinity

55

Presence of methemoglobin and Sulfhemoglobin

Shift to the left
Increase oxygen affinity

56

Amount of oxygen in 1g of hemoglobin

1.34mL

57

Amount of oxygen in 1g of hemoglobin

1.34mL