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Hemoglobin Flashcards

(58 cards)

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0
Q

Most functional iron in humans

A

Hemoglobin

Myoglobin

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1
Q

Respiratory pigment

A

Hemoglobin

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2
Q

Storage form of iron

A

Ferritin

Hemosiderin

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3
Q

Iron that is incorporated into hemoglobin molecules

A

Heme

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4
Q

Reduced form of iron

A

Ferrous

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5
Q

Best time to take iron supplements

A

Early morning

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6
Q

Transport protein for iron

A

Transferrin

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7
Q

Main component of RBC

A

Hemoglobin

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8
Q

In 1RBC, what is the concentration of hemoglobin?

A

34g/dL

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9
Q

1g of Hb contains (iron)

A

3.47mg

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10
Q

Other term for heme

A

Protoporphyrin IX

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11
Q

Composition of heme

A

Carbon
Hydrogen
Nitrogen
With ferrous

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12
Q

Has four polypeptide chains and each chain is attached to 1heme group

A

Globin

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13
Q

Globin comprises how many amino acids?

A

141-146

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14
Q

Heme synthesis occurs in? In what stage?

A

Bone marrow

From Pronormoblast to reticulocyte

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15
Q

By products of heme synthesis

A 
Delta aminolevulinic acid
Porphobilinogen
Uroporphyrinogen III
Coproporphyrinogen III
Protoporphyrinogen IX
Protoporphyrin IX
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16
Q

Chromosome 16

A

Alpha and zeta

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17
Q

Chromosome 11

A

Beta, delta, gamma, epsilon

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18
Q

Production of globin chains take place in what stage

A

Pronormoblast to reticulocyte

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19
Q

Beta globin mRNA is translated more efficiently than?

A

Alpha globin mRNA

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20
Q

Oxygenated hemoglobin

A

Oxyhemoglobin

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21
Q

Oxyhemoglobin color? Seen in?

A

Arterial blood-bright red

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22
Q

Gower I

A

Zeta and epsilon

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23
Q

Portland

Study These Flashcards
A

Zeta and gamma

24
Gower II
Alpha and epsilon
25
HbA
95% two alpha and two beta
26
HbA2
3-5% two alpha and two delta
27
HbF
1-2% two alpha and two gamma
28
HbF present in few RBC are called?
F cells
29
Formed by post synthetic, nonenzymatic reactions of various sugars with amino groups of the globin chain
HbA1
30
Normal adult hemoglobin
HbA HbA2 HbF
31
Reference range
Male=14-18g/dL Female=12-15g/dL Newborn =16.5-21.5g/dL
32
Deoxygenated hemoglobin color? Seen in?
Venous blood-dark red
33
Hemoglobin with Carbon monoxide
Carboxyhemoglobin
34
Carboxyhemoglobin color?
Cherry red in blood and skin
35
Hemoglobin contains iron in the ferric state
Methemoglobin
36
Exposure to oxidizing agent will result to production of?
Methemoglobin
37
Characteristic of methemoglobin in the blood
Chocolate brown color
38
Treatment of methemoglobin
Administration of ascorbic acid or methylene blue
39
Formed by the irreversible oxidation of Hb by certain drugs and chemical
Sulfhemoglobin
40
In vitro Sulfhemoglobin gives?
Greenish pigment
41
A key rate limiting step in heme synthesis is suppression of
Aminolevulinate synthase
42
Ferric oxidation product of heme
Hemin
43
Amount of oxygen needed to saturate 50% of hemoglobin
P50 value
44
Curve
Sigmoidal
45
How many oxygen is bound by each gram of hemoglobin
1.34mL
46
Shifts of the curve to the left or right occur if there are changes in the pH of the blood
Bohr effect
47
Normal PO2
27mm hg
48
Shifts to the left
Higher oxygen affinity | Lower release of oxygen
49
Shift to the right
Lower oxygen affinity | Higher release of oxygen
50
Its oxygen affinity is 240times and 10000 times slower oxygen release
Carboxyhemoglobin
51
Increase 2,3-BPG
Shift to the right. | Decrease oxygen affinity
52
Lower pH or increase in Hydrogen concentration
Shift to the right | Decrease oxygen affinity
53
Decrease PCO2
Shift to the left | Increase oxygen affinity
54
Increase in temperature
Shift to the right | Decrease oxygen affinity
55
Presence of methemoglobin and Sulfhemoglobin
Shift to the left | Increase oxygen affinity
56
Amount of oxygen in 1g of hemoglobin
1.34mL
57
Amount of oxygen in 1g of hemoglobin
1.34mL

Hematology (7 decks)

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