Primary Hemostasis, Platelet Function. Lab Tests

Question 1

Cellular elements of hemostasis

Answer 1

Vascular intima
Extracellular tissue factor bearing cells
Platelets

Question 2

Plasma components of hemostasis

Answer 2

Coagulation and fibrinolytic

Question 3

Structure of blood vessel wall

Answer 3

Vascular initima

Question 4

Rhomboid and contiguous

Answer 4

Endothelial cells

Question 5

Anticoagulant properties of Vascular intima

Answer 5

Lamina propia
Nitric oxide
Heparin sulfate
TFPI
Thrombomodulin
PGI2 or prostacyclin
TPA

Question 6

Activates fibrinolytic serum. Dissolves clot

Answer 6

TPA

Question 7

Vasodilator, inhibits platelet activation

Answer 7

Prostacyclin

Question 8

Activates protein C pathway. Digest factor Va and VIIIa

Answer 8

Thrombomodulin

Question 9

Inactivates coagulation factor VIIa

Answer 9

TFPI

Question 10

Inactivates extrinsic factor

Answer 10

TFPI

Question 11

Retards coagulation by activating antithrombin

Answer 11

Heparin sulfate

Question 12

Counteracts vasoconstriction

Answer 12

Nitric oxide

Question 13

Relaxing factor

Answer 13

Nitric oxide

Question 14

Promotes platelet activation and adhesion

Answer 14

Collagen

Question 15

Origin of collagen

Answer 15

Fibroblast

Question 16

Activates fibrin bound plasminogen to form plasmin

Answer 16

TPA

Question 17

Digest thrombus and restore blood flow

Answer 17

Plasmin

Question 18

Inhibits activation of fibrinolytic system

Answer 18

PAI-1

Question 19

Adhesion molecules

Answer 19

P-selectin
ICAM
PECAM

Question 20

Induce vasoconstriction

Answer 20

Smooth muscle cells

Question 21

Who secretes vWF

Answer 21

Endothelial cells

Question 22

Promotes leukocyte binding

Answer 22

ICAM

PECAM

Question 23

Promotes platelets and leukocytes binding

Answer 23

P selectin

Question 24

Platelets roll and cling to nonplatelet surfaces

Answer 24

Adhesion

Question 25

Platelet adheres to each other

Answer 25

Aggregation

Question 26

Platelets discharge the contents of their granules

Answer 26

Secretion

Question 27

Absence of GP IIb/IIIa

Answer 27

Glanzmann thrombostemia

Question 28

Absence of Gp Ib/IX

Answer 28

Bernard soulier syndrome

Question 29

Where is vWF being stored

Answer 29

Weible palade bodies

Question 30

Bind vWF

Answer 30

GP Ib/IX receptor

Question 31

For jigsaw puzzle effect

Answer 31

Pseudopod

Question 32

For crosslink to other platelet

Answer 32

GP IIb/IIIa

Question 33

Requires fibrinogen

Answer 33

Aggregation

Question 34

Requires extensive damage

Answer 34

Aggregation

Question 35

Reversible aggregation | Platelets adhere loosely to each other

Answer 35

Primary aggregation

Question 36

Irreversible aggregation | Release of substance that acts as antagonist

Answer 36

Secondary aggregation

Question 37

Substances that promotes coagulation

Answer 37

HMWK Fibrinogen Factor V Factor VIII:vWF

Question 38

Substances that promotes aggregation

Answer 38

ADP Calcium PF4 Thrombospondin

Question 39

Promotes vasoconstriction

Answer 39

Serotonin | Thromboxane A2

Question 40

Promotes vascular repair

Answer 40

PDGF | B-thromboglobulin

Question 41

Plasma precursors

Answer 41

Plasminogen

Question 42

Plasma inhibitors

Answer 42

Alpha-2-antiplasmin

Question 43

Complement system inhibitors

Answer 43

C1 esterase inhibitor

Question 44

Positive result of capillary fragility test

Answer 44

Petechiae

Question 45

Methods of Capillary fragility test

Answer 45

Tourniquet test Rumple Leed Gothlin Quick

Question 46

4+ petechiae

Answer 46

>50

Question 47

1+ petechiae

Answer 47

0-10

Question 48

2+ petechiae

Answer 48

11-20

Question 49

3+ petechiae

Answer 49

21-50

Question 50

Pinpoint hemorrhagic spots

Answer 50

Petechiae

Question 51

Correlates with the degree of thrombocytopenia

Answer 51

Capillary fragility test

Question 52

Original test for platelets

Answer 52

Bleeding time

Question 53

Normal value of Duke method

Answer 53

2-4mins

Question 54

Normal value of Ivy method

Answer 54

2-9mins

Question 55

Factors affecting bleeding time

Answer 55

Vascular integrity Platelet function Platelet count

Question 56

2 cuts in volar surface of hand

Answer 56

Ivy method

Question 57

Reason why platelet count is difficult

Answer 57

``` Platelets: .easily adhere to foreign surface .Easily disintegrate .difficult to distinguish from debris .unequal distribution in circulation ```

Question 58

Whole blood is diluted with diluting fluid in RBZc pipet and counted in hemocytometer

Answer 58

Direct platelet count

Question 59

Platelets are counted in relation to 1000 RBC in the PBS

Answer 59

Indirect platelet count

Question 60

Indirect methods

Answer 60

Damashek Fonio Olef

Question 61

Direct methods

Answer 61

Guy and Leake Reese Ecker Brecker cronkite Unopette

Question 62

Direct using light microscope

Answer 62

Reese Ecker | Guy and Leake

Question 63

Diluting fluid of Reese Ecker

Answer 63

Sodium citrate BCB Distilled water

Question 64

Guy and Leake diluting fluid

Answer 64

Sodium citrate or oxalate Crystal violet Formalin

Question 65

Diluent of brecker cronkite and use of diluent

Answer 65

1% ammonium oxalate | Hemolyzes RBC

Question 66

Damashek diluent

Answer 66

``` BCB Sodium citrate Distilled water Formalin Sucrose ```

Question 67

Best indirect method

Answer 67

Olef

Question 68

Diluent of Fonio

Answer 68

14% MgSO4

Question 69

Inhibits cyclopxygenase enzyme

Answer 69

Aspirin

Question 70

Inhibit GP IIb/IIIa

Answer 70

Tirofibom

Question 71

Inhibits ADP receptor

Answer 71

Clopidogrel bisulfate

Question 72

Inhibit circulating thrombin

Answer 72

Heparin

Question 73

Inhibit thrombin attach to fibrin

Answer 73

Hirudin

Question 74

Process by which blood is maintained within the vessel walls

Answer 74

Hemostasis