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Hematology > WBC Abnormality And Anomaly > Flashcards

WBC Abnormality And Anomaly Flashcards

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0
Q

Last stage of mitosis

A

Myelocyte

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1
Q

Increase in concentration of WBC

A

Luekocytosis

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2
Q

Term used to identify very immature cells seen on PBS

A

Blast

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3
Q

First morphologic stage where you can differentiate neutrophilic, eosinophilic and basophilic

A

Myelocyte

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4
Q

High NC ratio, finely reticular chromatin with nucleoli

A

Myeloblast

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5
Q

Blue cytoplasm with azurophilic granules

A

Promyelocyte

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6
Q

Nuclear remnants of lympho

Thumbprint appearance

A

Smudge cell

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7
Q

Classification of leukocytes

A

Granulation
Segmentation
Function

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8
Q

Lymphocyte Seen in nonmalignant reactive disorders

A

Variant lymphocyte

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9
Q

Stage: Synthesis of tertiary granules

A

Metamyelocyte

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10
Q

Formation of secretory vesicles

A

Band

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11
Q

Proposed by the NCCLS as the term of choice for this type of lymphocyte

A

Variant lymphocyte

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12
Q

Also called plasmacytoid lymphocyte and Turk irritation cell

A

Type 1

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13
Q

Macropolycyte

5-10 lobes. Seen in megaloblastic anemia

A

Hypersegmented neutrophils

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14
Q

Ruptured WBC with bare nucleus

Due to improper forceful smearing

A

Smudge cells

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15
Q

Vacuolated cell may be seen in

A

Severe infections
Chemical poisoning
Leukemia

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16
Q

Dark blue, ovoid non granular with russel bodies that produces proteins

A

Plasma cell

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17
Q

Seen in 88% of patients with cancer

A

Hairy cell

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18
Q

A phagocytic monocyte with engulfed nucleus of another cell

A

Tart cell

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19
Q

Predominant type seen in IM

Fried egg and flared skirt appearance

A

Type II

Infectious mononucleosis

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20
Q

A phagocytic neutrophil that has ingested an altered homogenous globular nuclear mass of destroyed cell

A

Lupus erythematosus cell

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21
Q

Wrinkled or onion skin like appearance

A

Gaucher bodies

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22
Q

Lymphocyte with notched lobulated or segmented or clover leaf like nucleus in chronic lymphocyte or lymphatic leukemia

A

Reider cells

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23
Q

Most valuable and reliable criterion for describing whether a WBC is mature or immature

A

Nuclear chromatin pattern

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24
Functionally immunocompetent. Probably of B Cell origin
type 1/ plasmacytoid lymphocyte
25
Characterized by the failure of the nucleus of neutrophils to segment or lobulate
Pelger huet anomaly
26
The appearance of this inclusions is transient only
Dohle bodies
27
Presence indicates increased cell fragility or cell destruction
Smudge cell
28
Tart cell may be seen in
Drug sensitivity
29
Granulation results from an abnormal deposition and storage of mucopolyssacharide Cytoplasmic granulation is not transient or related to an infection
Alder reilley anomaly
30
Genetic qualitative disorder with abundant sudanophilic inclusions
Jordan anomaly
31
Found in neutrophils as irregular, round or oval blue staining cytoplasmic inclusions About the size of cocci 2um
Dohle bodies
32
Most common increase. Non malignant
Increase neutrophil
33
With holes or vacuoles in the cytoplasm | Sign of degeneration
Vacuolated cell
34
Rare autosomal dominant, qualitative leukocyte abnormality
May Hegglin anomally
35
Greenish pigment
Sulfhemoglobin
36
Test used to differentiate dohle bodies and May hegglin anomaly
Periodic acid schiff
37
Normal size of WBC
9-15um
38
Believed to be altered primary granules | Color dar blue to black
Toxic granulation
39
Characterized by dense azurophilic granulation in all types of leukocytes
Alder Reilly anomaly
40
Czediak higashi patients display?
Partial albinism
41
Pince Nez form of neutrophil nucleus
Pelger huet anomaly
42
First describe in association with progressive muscular dystrophy and subsequently icthyosis
Jordan anomaly
43
Rod like bodies when stain reddish purple in the cytoplasm of myeloblast in acute myelocutic leukemia
Auer bodies
44
May hegglin Demonstrate?
Pale blue, spindle-shaped inclusions (2-5um)
45
Rare condition in which both fandom and directed movement of the cells are defective
Lazy leukocyte syndrome
46
Results from the proteinacious material produced by immune globulins Grape like structure
Russel bodies
47
Granules are believed to be normal in content but abnormally packaged
Czediak Higashi
48
Flame cells or flaming plasmacytes
Russel bodies
49
Accumulation of ganglioside and glycolipid
Tay sach
50
Release of cell from the marrow to the peripheral blood is poor
Lazy leukocyte syndrome
51
Alder Reilly is associated with?
Skeletal dystrophy | Gargoylism
52
Reduced form of iron
Ferrous
53
Gaucher bodies are the accumulation of what enzyme
Glucocerobroside
54
Bodies with glycoprotein component found in dysproteinemias
Dutcher bodies
55
Foamy or soap suds appearance
Niemann-Pick
56
Deficiency associated with tay sach
Hexosaminidase type A
57
Stain positively for fat
Jordan anomaly
58
Disease association of dohle bodies
Scarlet fever
59
Best time to take iron supplements
Early morning
60
Transport protein for iron
Transferrin
61
Most functional protein in human
Hemoglobin | Myoglobin
62
Storage form of iron
Ferritin | Hemosiderin
63
Other tern for heme
Protoporphyrin IX
64
Respiratory pigment
Hemoglobin
65
Chromosome 11
Beta, delta epsilon, gamma
66
Production of globin chain takes place in what stage
Pronormoblast
67
Diagnostic of acute myelogenous leukemia
Auer rods
68
Granules that kills bacteria once engulfed
Myeloperoxidase
69
Competes with iron supply
Lactoferrin
70
Translated more efficiently that alpha globin mRNA
B-globin mRNA
71
1 RBC
34g/dL
72
Gower II
Alpha and epsilon
73
Iron that is incorporated into hemoglobin molecule
Heme
74
Heme synthesis occurs in what part of the body?
Bone marrow
75
Major organelle of heme synthesis
Mitochondria
76
1st three months of embryonic development
Ontogeny
77
Oxygenated hemoglobin? What color? Seen in?
Oxyhemoglobin Bright red Arterial blood
78
Unable to act as an oxygen carrier
Non functional Hb
79
Gower 1
Zeta and epsilon
80
Irreversible reaction. Hypoxia results
Carboxyhemoglobin
81
Color of carboxyhemoglobin | Seen in
Cherry red | Blood and skin
82
What is my favorite color
Flesh pink
83
Contain ferric. Reaction is reversible
Methemoglobin
84
Degrade bacterial cell wall
Lysozyme
86
Nuclear remnants of granulocytic cells with net like chromatin pattern
Basket cell
87
Genetic disorder characterized by giant cytoplasmic granules in the phagocytes and lumphocytes
Czediak-Higashi syndrome
88
Linear projections of primary, azurophilic granules
Auer bodies
89
Large hypogranular platelets are seen
May Hegglin Anomaly
90
Infectious mononucleosis cell
Type II
91
Cartwheel pattern
Plasma cell
93
Plays a major role in parasitic infections and in hypersensitivity reaction
Eosinophil
94
Body soldiers
Leukocytes
95
Kidney or peanut shaped
Metamyelocyte
97
Seen im hexagonalbipyramidal crystals
Charcot leyden crystals
98
Neutral cytoplasm with no nucleus that is divided by thin filaments containing no internal chromatin into 2-5 lobes
Segmented neutrophil
99
Sieve like appearance of chromatin
Myeloblast
100
Robin egg blue cytoplasm
Lymphocyte
101
Slight clumping chromatin
Promyelocyte
103
Juvenile stage
Metamyelocyte
103
Tertiary granules?
Gelatinase granules
104
May appear as undefined blast cell
Immature monocyte
105
Caused by a mutation of the lamin B
Pelger huet anomaly
106
Granules that play a major role in the cell's ability to damage parasitic invaders
Major basic protein
107
Structural abnormality in the Myeloperoxidase gene
Alder reilly anomaly
108
Include giant lysosomal granules in granulocytes, monocyte and lymphocytes
Czediak higashi
109
Important marker on inflammation. Induced by increases in granulocyte CSF
Toxic granulation
110
Charcot leyden is composed of
Lysophospholipase
111
Stains light pink with many small specific granules that give cytoplasm a grainy appearance
Neutrophil
111
May demonstrate pseudopods
Monocyte
113
S, C or U shaped
Band
114
Dawn of neutrophilia
Myelocyte

Hematology (7 decks)

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