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Flashcards in WBC Abnormality And Anomaly Deck (112):
0

Increase in concentration of WBC

Luekocytosis

1

Last stage of mitosis

Myelocyte

2

Term used to identify very immature cells seen on PBS

Blast

3

First morphologic stage where you can differentiate neutrophilic, eosinophilic and basophilic

Myelocyte

4

High NC ratio, finely reticular chromatin with nucleoli

Myeloblast

5

Blue cytoplasm with azurophilic granules

Promyelocyte

6

Nuclear remnants of lympho
Thumbprint appearance

Smudge cell

7

Classification of leukocytes

Granulation
Segmentation
Function

8

Lymphocyte Seen in nonmalignant reactive disorders

Variant lymphocyte

9

Stage: Synthesis of tertiary granules

Metamyelocyte

10

Formation of secretory vesicles

Band

11

Proposed by the NCCLS as the term of choice for this type of lymphocyte

Variant lymphocyte

12

Also called plasmacytoid lymphocyte and Turk irritation cell

Type 1

13

Macropolycyte
5-10 lobes. Seen in megaloblastic anemia

Hypersegmented neutrophils

14

Ruptured WBC with bare nucleus
Due to improper forceful smearing

Smudge cells

15

Vacuolated cell may be seen in

Severe infections
Chemical poisoning
Leukemia

16

Dark blue, ovoid non granular with russel bodies that produces proteins

Plasma cell

17

Seen in 88% of patients with cancer

Hairy cell

18

A phagocytic monocyte with engulfed nucleus of another cell

Tart cell

19

Predominant type seen in IM
Fried egg and flared skirt appearance

Type II
Infectious mononucleosis

20

A phagocytic neutrophil that has ingested an altered homogenous globular nuclear mass of destroyed cell

Lupus erythematosus cell

21

Wrinkled or onion skin like appearance

Gaucher bodies

22

Lymphocyte with notched lobulated or segmented or clover leaf like nucleus in chronic lymphocyte or lymphatic leukemia

Reider cells

23

Most valuable and reliable criterion for describing whether a WBC is mature or immature

Nuclear chromatin pattern

24

Functionally immunocompetent. Probably of B Cell origin

type 1/ plasmacytoid lymphocyte

25

Characterized by the failure of the nucleus of neutrophils to segment or lobulate

Pelger huet anomaly

26

The appearance of this inclusions is transient only

Dohle bodies

27

Presence indicates increased cell fragility or cell destruction

Smudge cell

28

Tart cell may be seen in

Drug sensitivity

29

Granulation results from an abnormal deposition and storage of mucopolyssacharide
Cytoplasmic granulation is not transient or related to an infection

Alder reilley anomaly

30

Genetic qualitative disorder with abundant sudanophilic inclusions

Jordan anomaly

31

Found in neutrophils as irregular, round or oval blue staining cytoplasmic inclusions
About the size of cocci 2um

Dohle bodies

32

Most common increase. Non malignant

Increase neutrophil

33

With holes or vacuoles in the cytoplasm
Sign of degeneration

Vacuolated cell

34

Rare autosomal dominant, qualitative leukocyte abnormality

May Hegglin anomally

35

Greenish pigment

Sulfhemoglobin

36

Test used to differentiate dohle bodies and May hegglin anomaly

Periodic acid schiff

37

Normal size of WBC

9-15um

38

Believed to be altered primary granules
Color dar blue to black

Toxic granulation

39

Characterized by dense azurophilic granulation in all types of leukocytes

Alder Reilly anomaly

40

Czediak higashi patients display?

Partial albinism

41

Pince Nez form of neutrophil nucleus

Pelger huet anomaly

42

First describe in association with progressive muscular dystrophy and subsequently icthyosis

Jordan anomaly

43

Rod like bodies when stain reddish purple in the cytoplasm of myeloblast in acute myelocutic leukemia

Auer bodies

44

May hegglin Demonstrate?

Pale blue, spindle-shaped inclusions (2-5um)

45

Rare condition in which both fandom and directed movement of the cells are defective

Lazy leukocyte syndrome

46

Results from the proteinacious material produced by immune globulins
Grape like structure

Russel bodies

47

Granules are believed to be normal in content but abnormally packaged

Czediak Higashi

48

Flame cells or flaming plasmacytes

Russel bodies

49

Accumulation of ganglioside and glycolipid

Tay sach

50

Release of cell from the marrow to the peripheral blood is poor

Lazy leukocyte syndrome

51

Alder Reilly is associated with?

Skeletal dystrophy
Gargoylism

52

Reduced form of iron

Ferrous

53

Gaucher bodies are the accumulation of what enzyme

Glucocerobroside

54

Bodies with glycoprotein component found in dysproteinemias

Dutcher bodies

55

Foamy or soap suds appearance

Niemann-Pick

56

Deficiency associated with tay sach

Hexosaminidase type A

57

Stain positively for fat

Jordan anomaly

58

Disease association of dohle bodies

Scarlet fever

59

Best time to take iron supplements

Early morning

60

Transport protein for iron

Transferrin

61

Most functional protein in human

Hemoglobin
Myoglobin

62

Storage form of iron

Ferritin
Hemosiderin

63

Other tern for heme

Protoporphyrin IX

64

Respiratory pigment

Hemoglobin

65

Chromosome 11

Beta, delta epsilon, gamma

66

Production of globin chain takes place in what stage

Pronormoblast

67

Diagnostic of acute myelogenous leukemia

Auer rods

68

Granules that kills bacteria once engulfed

Myeloperoxidase

69

Competes with iron supply

Lactoferrin

70

Translated more efficiently that alpha globin mRNA

B-globin mRNA

71

1 RBC

34g/dL

72

Gower II

Alpha and epsilon

73

Iron that is incorporated into hemoglobin molecule

Heme

74

Heme synthesis occurs in what part of the body?

Bone marrow

75

Major organelle of heme synthesis

Mitochondria

76

1st three months of embryonic development

Ontogeny

77

Oxygenated hemoglobin?
What color?
Seen in?

Oxyhemoglobin
Bright red
Arterial blood

78

Unable to act as an oxygen carrier

Non functional Hb

79

Gower 1

Zeta and epsilon

80

Irreversible reaction. Hypoxia results

Carboxyhemoglobin

81

Color of carboxyhemoglobin
Seen in

Cherry red
Blood and skin

82

What is my favorite color

Flesh pink

83

Contain ferric. Reaction is reversible

Methemoglobin

84

Degrade bacterial cell wall

Lysozyme

86

Nuclear remnants of granulocytic cells with net like chromatin pattern

Basket cell

87

Genetic disorder characterized by giant cytoplasmic granules in the phagocytes and lumphocytes

Czediak-Higashi syndrome

88

Linear projections of primary, azurophilic granules

Auer bodies

89

Large hypogranular platelets are seen

May Hegglin Anomaly

90

Infectious mononucleosis cell

Type II

91

Cartwheel pattern

Plasma cell

93

Plays a major role in parasitic infections and in hypersensitivity reaction

Eosinophil

94

Body soldiers

Leukocytes

95

Kidney or peanut shaped

Metamyelocyte

97

Seen im hexagonalbipyramidal crystals

Charcot leyden crystals

98

Neutral cytoplasm with no nucleus that is divided by thin filaments containing no internal chromatin into 2-5 lobes

Segmented neutrophil

99

Sieve like appearance of chromatin

Myeloblast

100

Robin egg blue cytoplasm

Lymphocyte

101

Slight clumping chromatin

Promyelocyte

103

Juvenile stage

Metamyelocyte

103

Tertiary granules?

Gelatinase granules

104

May appear as undefined blast cell

Immature monocyte

105

Caused by a mutation of the lamin B

Pelger huet anomaly

106

Granules that play a major role in the cell's ability to damage parasitic invaders

Major basic protein

107

Structural abnormality in the Myeloperoxidase gene

Alder reilly anomaly

108

Include giant lysosomal granules in granulocytes, monocyte and lymphocytes

Czediak higashi

109

Important marker on inflammation. Induced by increases in granulocyte CSF

Toxic granulation

110

Charcot leyden is composed of

Lysophospholipase

111

Stains light pink with many small specific granules that give cytoplasm a grainy appearance

Neutrophil

111

May demonstrate pseudopods

Monocyte

113

S, C or U shaped

Band

114

Dawn of neutrophilia

Myelocyte