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Flashcards in Prelim Deck (101):
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Refers to the volume of RBC that occupies a given volume of WBC

Hematocrit

1

Many shaped nucleus

Neutrophils

2

Study of blood cells

Hematology

3

Liquid portion of the blood

Plasma

4

Reddish protein responsible for the color of RBC

Hemoglobin

5

Transport oxygen and carbon dioxide

RBC

6

Means a loss in oxygen-carrying capacity and is often reflected in a reduced RBC count

Anemia

7

Means an increases RBC count reflecting increased body RBC mass, a condition that leads to hyperviscosity

Polycythemia

8

Composition of Drabkin reagent?

Potassium cyanide
Potassium ferricyanide

9

Formulation of ionic surfactant used to reduce environmental cyanide

Sodium dodecyl sulfate

10

Ratio of the volume of RBCs to the whole blood

Hematocrit

11

I packed cell volume

Hematocrit

12

Light colored layer between the RBC and platelets

Buffy coat

13

Reflects RBC diameter on a Wright stain blood film

Mean Cell Volume -MCV

14

Reflects staining intensity or degree of palor

Mean cell hemoglobin concentration

15

Expresses mass of hemoglobin and closely reflects the MCHC

Mean Cell hemoglobin MCH

16

Stained slightly blue gray

Reticulocytes

17

Extreme increase in the WBC counts impart milky appearance

Chronic leukemia

19

Decrease WBC count

Leukopenia

20

Phagocytic cells whose sole purpose is to engulf and destroy bacteria that have been earlier labeled as harmful

Polymorphonuclear neutrophils/segmented neutrophils/segs

21

Increase in segs,often signals bacterial infection

Neutrophilia

22

Indicates bone marrow regeneration during blood loss and certain anemia

Reticulocytes

24

Decrease, caused by long term drug administration or a viral infection

Neutropenia

25

With pink staining granules, S or C shaped nucleus

BANDS, band neutrophils

26

2-um in diameter, round or oval, anucleate, slightly granular.

Platelets

28

Most abundant cell in the body

Macrophages

29

Increase WBC count

Leukocytosis

30

Elevated eosinophil count signals a response to allergy or parasitic infection

Eosinophilia

31

Dark purple, irregular cytoplasmic granules that obscure the nucleus

Basophils

33

A series of cellular and plasma based mechanism that seals wounds, repair vessel walls and maintain vascular patency

Platelets

34

Nearly round, slightly larger than RBC, have round featureless nuclei, a thin rim of nongranular cytoplasm

Lymphocytes

35

Nearly colorless; loosely related grouping of cell families dedicated to protecting their host from infection and injury

White blood cell

36

Bright orange, regular cytoplasmic granules filled with antihistamine

Eosinophils

38

Adhere to the surfaces of damaged blood vessels, secrete proteins and small molecules that trigger thrombosis or clot formation.

Platelets

39

Elevated basophils, hematologic disease

Basophilia

40

complex system of cells that provides fir host immunity

Lymphocytes

41

Abnormally low-long term drug therapy or immunodeficiency

Lymphopenia/lymphocytopenia

42

True blood cells, that maintain blood vessels integrity by instigating vessel wall repairs

Platelets/thrombocytes

43

Immature macrophage passing through the blood

Monocytes

45

Changing from supine to standing or sitting

Increase test values: lipids, enzymes, protein

46

Decrease in the afternoon

Cortisol and adrenocorticotropic hormone

47

Increase in the afternoon

Iron and eosinophil

48

Used to provide a barrier against venous blood flow to help locate vein

Tourniquets

49

The tourniquets should be applied at? For how long?

2-4 in above the venipuncture site.
Not longer than 1min

50

Inhibits the use if glucose by blood cells. Ex. Sodium fluoride and lithium iodoacetate

Antiglycolytic agent

51

What is the physiologic pH of the blood

7.35-7.45

52

What additives are combined with sodium fluoride to obtain plasma?

Potassium oxalate and potassium EDTA

53

Prevents blood from clotting

Anticoagulant

54

Additive present in red top

Clot activator

55

Serve as separation barrier between the serum/plasma and cells

Separator gel

56

Additive in yellow tube used for blood culture specimen collection

Sodium polyanethol sulfonate

57

Most common needle size and length for adult venipuncture

21gauge: 1inch

58

Intravenous device that consists of a short needle and a thin tube with attached plastic wings

Butterflies

59

Solution used in cleansing venipuncture site when alcohol determination is requested

Benzalkonium chloride

60

Vein of choice for venipuncture

Median cubital vein

61

Recommended angle between the needle and the skin during venipuncture

15-30 degrees

62

Mechanism of action of fibrin as an anticoagulant

Heparin inhibits thrombin

63

Most crucial step for blood collection

Patient identification

64

Ratio of blood to anticoagulant

9:1

65

Most common complication encountered in blood collection

Ecchymosis or bruise

66

Skin puncture site for infants

Lateral surface of the heel

67

Skin puncture sites for older children and adults

Palmar surface of the distal portion of ring or middle finger

68

Required puncture depth

Less than 2mm

69

Refers to error occur without predictions

Random error

70

Progressive decrease or increase

Drift or trend

71

Lack precision

Dispersion

72

On one side of the mean

Shift or abrupt change

73

Start of mesoblasstic phase

19th day of fetal development

74

Chief site of mesoblastic phase

Yolk sac

75

Predominant cell

Primitive erythroblast

76

Predominant cells of hepatic phase

Erythroblast, granulocytes, and monocytes

77

Peak of hepatic phase

3rd month

78

Chief site of hepatic phase

Liver

79

In hepatic phase what are the detectable hemoglobin present?

Hb F, HbA and HbA2

80

Chief site of myeloid phase

Bond marrow red

81

An embryonic tissue that migrate into the core of the bone and differentiate into skeletal and hemapoietic blood cells

Mesenchymal cells

82

Measurable levels of myeloid

EPO, G-CSF, GM-CSF fetal hemoglobin, Hb A2

83

First bone to demonstrate

Clavicle

84

Largest organ in the body

Bone marrow

85

Hematopoietically active bone marrow

Red marrow

86

Provides a supportive network for developing hematopoietic cells, macrophages, mast cells

Reticular cell

87

Process of replacing red marrow by yellow marrow during the development

Retrogression

88

Maintain proliferation and differentiation of blood cells

Hemapoietic microenvironment

89

Site for hematopoiesis if bone marrow shuts down

Liver

90

Largest lymphoid organ

Spleen

91

Cells are phagocytosed with subsequent degradation of cell organelles

Culling

92

Splenic macrophages remove inclusions or damaged surface membrane from circulating RBC

Pitting

93

All blood cells are derived from a single progenitor stem cell called pluripotential stem cell

Monophyletic theory

94

Each of the blood lineages derived from its own unique stem cell

Polyphyletic theory

95

Capable of sel renewal

Stem cell

96

HSCs randomly commits to self renewal or differentiation

Stochastic

97

Microenvironment in the bone marrow determines whether stem cell will self renew or differentiate

Instructive model

98

Cells fate determined by its extrinsic and intrinsic factors

Multilineage priming model

99

Progenitor of neutrophils

GMP

100

Major cytokine for the stimulation of neutrophil production

G-CSF

101

Control hemostasis

Platelets

102

Increase monocytes-hematologic disease

Monocytosis

105

Increase lymphocytes-viral infection

Lymphocytosis

106

Slightly larger diameter than other WBCs, gray cytoplasm, lobulated nuclues

Monocytes

114

Stain used to differentiate and count young RBC, hemoglobin H, and heinz body

Supravital stain/new methylene blue

136

Normal size of RBC

6-8um in diameter