hemostasis

Question 1

hemostasis

Answer 1

using platelets, coagulation factors, and fibrin to stop bleeding after injury to vessels

Question 2

coagulation factors

Answer 2

• zymogen
• -> k dependent
• -> K independent
• cofactors
• non protein cofactors
• fibrinogen and factor XIII

Question 3

k dependent coagulation factors

Answer 3

2, 7, 9, 10, C, and S

Question 4

intrinsic pathway

Answer 4

12 –> 12a
11 –> 11a
9 –> 9a
8 –> 8a

Question 5

extrinsic pathway

Answer 5

7 + TF –> 7 a
calcium
phospholipid bilayer

Question 6

common pathway

Answer 6

X –> Xa

Question 7

prothrombin

Answer 7

factor II; forms thrombin

Question 8

thrombin

Answer 8

activates fibrinogen to form fibrin

Question 9

fibrinogen

Answer 9

D – E – D

BB AA Y

Question 10

fibrin

Answer 10

B and A

Question 11

d-dimer

Answer 11

molecule degradation product of cross-linked fibrin; it reflects ongoing activation of the hemostatic system

Question 12

with a patient who has a low pretest probability of clot … d-dimer would help rule out clot if the results are

Answer 12

negative

Question 13

primary hemostasis

Answer 13

vasoconstriction and platelet

Question 14

secondary hemostasis

Answer 14

coagulation factors

Question 15

tertiary hemostasis

Answer 15

fibrin

Question 16

platelets are formed from

Answer 16

megakaryocytes cytoplasm

Question 17

platelet lifespan

Answer 17

7-10 days

Question 18

non-protein cofactor

Answer 18

calcium and phospholipid surfaces

Question 19

factor XIII

Answer 19

cross-links fibrin

Question 20

cofactor coagulation factors

Answer 20

5 and 8, tissue factor, and von willebrand factor

Question 21

coagulation factors with the shortest half life and smallest plasma concentration

Answer 21

factor 7, 8, and protein C

Question 22

activated platelets release granules

Answer 22

ADP, thromboxane A2 and recruit more platelets and promote aggregation

Question 23

platelet glycoprotein IIb/IIIa

Answer 23

intergrin receptors; adhere to fibrinogen, enhance aggregation and stabilize thrombus

Question 24

fribin stabilizes the

Answer 24

the growing platelet thrombus

Question 25

endothelial cells release

Answer 25

- prostacyclins - nitric oxide both of which inhibit further platelet aggregation

Question 26

prostacyclin

Answer 26

It inhibits platelet activation and is also an effective vasodilator.

Question 27

thrombin has both procoagulant and anitcoagulant properties. What makes it an anticogulatant

Answer 27

complexed with thrombomodulin