leukemia

Question 1

acute myeloid leukemia (AML) is common in what age group

Answer 1

adults

Question 2

acute lymphoblastic leukemia (ALL) is common in what age group

Answer 2

children

Question 3

common side effect of AML

Answer 3

DIC

Question 4

leukemia

Answer 4

neoplasia within the hemopoietic stem cell pathway

Question 5

acute promyelocyte leukemia has what translocation?

Answer 5

(15;17)

Question 6

ALL has what common markers?

Answer 6

CD10, CD19 and TdT

Question 7

AML is commonly know to have what on the peripheral smear?

Answer 7

auer rods

Question 8

treatment for acute promyelocyte leukemia ?

Answer 8

ATRA

all trans retinoic acid + arsenic

Question 9

what translocation is a bad prognosis cytogenetic marker for ALL?

Answer 9

(9;22)

Question 10

what is a good prognosis cytogenetic marker for ALL?

Answer 10

(12,21)

Question 11

what is a bad prognosis comorbity for ALL?

Answer 11

down syndrome

Question 12

What is the common finding for hemoglobin, platelet, and neutrophil and leukocyte count for acute leukemia?

Answer 12

anemia, neutropenia, thrombocytopenia, and leukocytosis

Question 13

acute myeloid leukemia arrests cells in what stage?

Answer 13

myeloblast

Question 14

ALL arrest cells in what stage?

Answer 14

lymphoblast pre-b and pre-t cells

Question 15

B-Cell/T-cell ALL has a worse prognosis?

Answer 15

T-cell

Question 16

what is common with T-cell ALL

Answer 16

mediastinal mass that is termed t cell lymphoblastic lymphoma

Question 17

AML can arise from

Answer 17

other disease like myeloproliferative or de novo mutation

Question 18

three factors for bad prognosis for AML

Answer 18

1. increased age
2. having previous disease or treatment
3. deletion of 5 and 7 chromosome

Question 19

CLL effects what type of cell?

Answer 19

mature B cells

Question 20

CLL can cuase hyperglobinuremia/hypoglobinuremia and what is the importance of this?

Answer 20

hypoglobinuremia , number one cause of death is infection because does not have Ig

Question 21

what type of cell is seen on a blood smear for CLL?

Answer 21

smudge cell

Question 22

what cytogenetic markers are seen in a patient with CLL?

Answer 22

CD5 and CD23

Question 23

what type of anemia is common in CLL?

Answer 23

autoimmune hemolytic anemia

Question 24

does CLL have to be treated?

Answer 24

no

Question 25

what cytogenic marker is found in CML?

Answer 25

t(9,22)

Question 26

how do you treat CML?

Answer 26

imatinib

Question 27

how do you diagnose CML?

Answer 27

FISH, QPCR, karyotype

Question 28

what is characteristic of CML blood smear?

Answer 28

increased basophils heterogenous Increased myeloid to erythroid ratio

Question 29

what happens if CML is not treated?

Answer 29

it can form acute leukemia

Question 30

Rai classification for leukemia?

Answer 30

``` o Stage 0- Lymphocytosis o Stage I- + Lymphadenopathy o Stage II- + Splenomegaly o Stage III- + Anemia o Stage IV- + Thrombocytopenia ```

Question 31

B cell markers

Answer 31

CD 19, 20, 21, 22, 23

Question 32

T cell markers-

Answer 32

CD 1, 2, 3, 4, 5, 7, 8

Question 33

CD34

Answer 33

Stem Cell Marker

Question 34

Myelomonocytic Marker

Answer 34

CD33

Question 35

Monocyte Markers

Answer 35

granulocyte: CD 13 and 15, monocyte CD 14

Question 36

Flow Cytometry Positional: - Forward spread: - Reverse spread:

Answer 36

Positional: - Forward spread: size - Reverse spread: complexity

Question 37

what has the largest revers and forward spread?

Answer 37

neutrophils