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Flashcards in HIV drugs Deck (25):
1

neuraminidase inhibitors

zanamivir, oseltamivir
decr progeny release (influenza)

2

Ribavirin

inhibits IMP dehydrogenase --> decr guanin
RSV, chronic HCV
Tox: hemolytic anemia, severe teratogen

3

Acyclovir

guanosine analog. phosphorylated by HSV/VZV thymidine kinase. inhibits viral DNA poly by chain termination.
No effect on CMV
valacyclovir has better oral bioavailability
resistance via mutx in thymidine kinase

4

Gancyclovir

5' monophosphate formed by CMV kinase. guanosine analog. inhibits viral DNApol
valganciclovir, prodrug, has better oral avail
leukopenia, neturopenia, thrombocytopenia, renal toxicity
resistance via mutx or absent viral kinase

5

foscarnet

pyrofosphate analog. DNA pol inhibitor
CMV retinitis (2nd line to ganciclovir), acyclovir-resistant HSV
Nephrotoxic
resistance via mutx to DNA pol

6

Cidofovir

inhibits DNA pol. does not require phosphorylation
CMV retinitis and acyclovir-resistant HSV
Nephrotoxic (co administer with probenecid and IV saline)

7

Protease inhibitors

"-navirs"
inhibit pol
cause hyperglycemia, GI upset, lipodystrophy.
Crystal-induced nephropathy, esp indinavir

8

indinavir

protease inhibitor
crystal-induced nephropathy

9

Ritonavir

protease inhibitor
"boosts" other drugs by inhibiting P450

10

Tenofovir

NRTI
terminate chain (no 3'OH group
Tenofovir does NOT have to be activated (nucleotide anolog)
BM suppression, peripheral neuropathy, lactic acidosis

11

Emtricitabine

NRTI
terminate chain (no 3' OH group)
nucleoside; must be activated
BM suprpession, peripheral neruopathy, lactic acidosis

12

Abacavir

NRTI
terminate chain (no 3' OH group)
nucleoside; must be activated
BM suprpession, peripheral neruopathy, lactic acidosis

13

Lamivudine

NRTI
terminate chain (no 3' OH group)
nucleoside; must be activated
BM suprpession, peripheral neruopathy, lactic acidosis

14

Zidovudine

NRTI
terminate chain (no 3' OH group)
nucleoside; must be activated
BM suprpession, peripheral neruopathy, lactic acidosis
**used for general PPX and pregnancy. causes anemia

15

Didanosine

NRTI
terminate chain (no 3' OH group)
nucleoside; must be activated
BM suprpession, peripheral neruopathy, lactic acidosis

16

Stavudine

NRTI
terminate chain (no 3' OH group)
nucleoside; must be activated
BM suprpession, peripheral neruopathy, lactic acidosis

17

Nevirapine

NNRTI
Bind RT at different site. do not require activation
BM suppression, peripheral neuropathy, rash

18

Efavirenz

NNRTI
Bind RT at different site. do not require activation
BM suppression, peripheral neuropathy, rash

19

Delavirdine

NNRTI
Bind RT at different site. do not require activation
BM suppression, peripheral neuropathy, rash

20

Raltegravir

Integrase inhibitor
Inhibits HIV genome integration into host cell chromosome by reversible inhibition of HIV integrase
causes hypercholesterolemia

21

IFN alpha

chronic HBV/HCV, kaposi's

22

IFN beta

MS

23

IFN gamma

NADPH oxidase deficiency

24

enfuviritide

fusion inhibitor
targets gp41

25

maravinoc

CCR5 receptor inhibitor