Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step 1 > Oncogenes/Tumor Supressors > Flashcards

Oncogenes/Tumor Supressors Flashcards

1
Q

abl

A

Oncogene
CML
Tyrosine Kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

c-myc

A

Oncogene
Burkitt’s
Transcription Factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

bcl-2

A

Oncogene
Follicular and undifferentiated lymphomas
stabilizer of mitochondrial membrane (anti-apoptosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

HER2/neu/c-erbB2

A

Oncogene
Breast, ovarian, gastric carcinoma
Tyrosine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ras

A

Oncogene
colon carcinoma
GTPase, MAP pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

L-myc

A

Oncogene
Lung tumor
transcription factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

N-myc

A

Oncogene
Neuroblastoma
transcription factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ret

A

Oncogene
MEN 2A/2B
Tyrosine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

c-kit

A

Oncogene
GI stromal tumor (GIST)
Cytokine Receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Rb

A

tumor suppressor
Retinoblastoma, osteosarcoma
Inhibits E2F; blocks G1 –> S
bound by E7 in HPV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

p53

A

tumor suppressor
most cancers, Li-Fraumeni syndrome
Blocks G1-> S
Bound by E6 in HPV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

BRCA1/2

A

tumor suppressor
Breast and ovarian Ca
DNA repair

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

p16

A

tumor suppressor

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

BRAF

A

tumor suppressor

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

APC

A

tumor suppressor – maintains CAMs and decr beta-catenin (oncogenic)
CRC (FAP)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

WT1

A

tumor suppressor

Wilm’s tumor

17
Q

NF1

A

tumor suppressor
NF1
RAS GTPas activating protein

18
Q

NF2

A

tumor suppressor
NF2
Merlin (schwannomin) protein

19
Q

DPC4

A

tumor suppressor

Pancreatic cancer

20
Q

DCC

A

tumor suppressor

colon cancer

Step 1 (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions