Oncogenes/Tumor Supressors Flashcards Preview

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Flashcards in Oncogenes/Tumor Supressors Deck (20):
1

abl

Oncogene
CML
Tyrosine Kinase

2

c-myc

Oncogene
Burkitt's
Transcription Factor

3

bcl-2

Oncogene
Follicular and undifferentiated lymphomas
stabilizer of mitochondrial membrane (anti-apoptosis)

4

HER2/neu/c-erbB2

Oncogene
Breast, ovarian, gastric carcinoma
Tyrosine kinase

5

ras

Oncogene
colon carcinoma
GTPase, MAP pathway

6

L-myc

Oncogene
Lung tumor
transcription factor

7

N-myc

Oncogene
Neuroblastoma
transcription factor

8

ret

Oncogene
MEN 2A/2B
Tyrosine kinase

9

c-kit

Oncogene
GI stromal tumor (GIST)
Cytokine Receptor

10

Rb

tumor suppressor
Retinoblastoma, osteosarcoma
Inhibits E2F; blocks G1 --> S
bound by E7 in HPV

11

p53

tumor suppressor
most cancers, Li-Fraumeni syndrome
Blocks G1-> S
Bound by E6 in HPV

12

BRCA1/2

tumor suppressor
Breast and ovarian Ca
DNA repair

13

p16

tumor suppressor
melanoma

14

BRAF

tumor suppressor
melanoma

15

APC

tumor suppressor -- maintains CAMs and decr beta-catenin (oncogenic)
CRC (FAP)

16

WT1

tumor suppressor
Wilm's tumor

17

NF1

tumor suppressor
NF1
RAS GTPas activating protein

18

NF2

tumor suppressor
NF2
Merlin (schwannomin) protein

19

DPC4

tumor suppressor
Pancreatic cancer

20

DCC

tumor suppressor
colon cancer