Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematology > Hodgkin Lymphoma > Flashcards

Hodgkin Lymphoma Flashcards

1
Q

What are Hodgkin lymphoma

A

Lymphoid neoplasms affecting lymph node

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Macro Hodgkin lymphoma

A

Large dysplastic mononuclear and multi ulcerated cells

Surrounded by mixture of mature non neoplastic inflammatory cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Is lymphadenopathy common in Hodgkin lymphoma

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Who discovered Hodgkin lymphoma

A

Thomas Hodgkin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Who discovered the abnormal cell that defines Hodgkin lymphoma

A

Dorothy reed

Carl sternberg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Key characteristics of Hodgkin lymphoma

A

R-S cells presence in cancerous areas
B cell origin cancerous cells
EBV in 40-50% cases
Overproduction of IL-13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are R-S cells

A

Bi or multinucleated cells

Each nucleus contains one prominent nucleolus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Are all Hodgkin’s cells multinucleated

A

No only R-S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What cells do you see in lymph node with Hodgkin lymphoma

A 
Tumor cells 
Réactive lymphocytes
Plasma cells
Macrophages 
Neutrophils 
Eosinophils
Fibrosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Incidence higher in women or men

A

Men

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Peaking age of Hodgkin lymphoma

A

Third decades

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Main type of Hodgkin lymphoma

A

Classical HD - 90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Peak age for classical Hodgkin lymphoma

A

15-35

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Type of Hodgkin lymphoma that tend to occur in young adults

A

Nodular sclerosis Hodgkin lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Occupational hazard that lead to Hodgkin lymphoma

A

Wood dust
Benzene exposure
Nitrous oxide in dental anesthetics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Virus that is associated with Hodgkin lymphoma

A

EBV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Type of Hodgkin lymphoma with highest incidence of EBV

A

Mixed cellularity Hodgkin lymphoma

18
Q

Type of population with Hodgkin lymphoma most affected by EBV

A

Children and elderly with mixed cellularity

19
Q

Genes associated with Hodgkin lymphoma

A

T(14;18)

BCL2 protein in R-S cells

HIV virus

20
Q

How much does HIV elevates risk of Hodgkin lymphoma

A

By 5 fold

21
Q

Why are molecular studies difficult in Hodgkin lymphoma

A

R-S malignant cells comprise less than 2% of total cells in nodes of Hodgkin lymphoma

22
Q

Method used to find point putation in P53 in Hodgkin lymphoma

A

PCR

23
Q

Cytokines that increase in Hodgkin lymphoma

A

IL1-9
TGF-beta
TNF

24
Q

Clinical features of Hodgkin lymphoma

A

Peripheral lymphadenopathy
Spread through lymph
B symptoms - night sweats, fever, weight loss
Alcohol induced pain in affected lymoh node
Cough , chest pain, dysnoea ( young patients)

25
Q

2 types of Hodgkin lymphoma based on immunochemistry and morphology

A

Classical HL - 90%

Nodular lymphocyte predominant Hodgkin lymphoma

26
Q

Histo logical classsifiation of Hodgkin lymphoma

A

Lymphocyte rich - 5%
Nodular sclerosing- 70%
Mixed cellularity - 20-25%
Lymphocyte depleted- less than 2%

27
Q

What is lymphocyte rich Hodgkin lymphoma

A

Infiltrate with small lymphocyte , few eosinophils, R-S cells , mononuclear cells

28
Q

What is nodular sclerosing Hodgkin lymphoma

A

Broad bands of connective tissue divide lymph node into nodules
Mixture of R-S, mononuclear H cells, plasma cells, macrophages, eosinophils

29
Q

What is mixed cellularity Hodgkin lymphoma

A

Infiltrate of same cells like other types with a lot of R-S cells
Focal necrosis
Fibrosis

30
Q

Lymphocyte depleted Hodgkin lymphoma

A

High mononuclearr hogdkin cells
R-S present
Few lymphocytes

31
Q

In which stage of Hodgkin lymphoma do you mostly see lymphocyte depleted Hodgkin lymphoma

A

III or IV

32
Q

Is lymphocyte depleted Hodgkin lymphoma common in HIV + patients

A

Yes

33
Q

Staging of Hodgkin lymphoma

A
34
Q

Diagnosis of Hodgkin lymphoma

A 
History 
Physical exam 
Lymph node biopsy 
FBC comment
Bone marrow staging 
LDH
Uris acid 
Spleen size imaging to see involvement 
Cx ray - intrathoracic involvement 
CT chest , abdomen , pelvis - extranodal pulmonary involvement
35
Q

Prognosis worse for male or female

A

Male

36
Q

Poor prognosis marker

A 
Male 
Old age , more than 50 yo
Advanced disease 
Low albumin 
Anemia
37
Q

Treatment Hodgkin lymphoma

A

Chemotherapy

Radiotherapy

38
Q

Treatment of choice in combination chemotherapy for advanced disease Hodgkin lymphoma

A 
ABVD 
Adriamycin
Bleomycin
Vincristine
Darcabazine
39
Q

COPP combination chemotherapy consists of

A

Cyclophosphamide
Oncovin
Prednisolone
Procabazine

40
Q

What do you give in relapses or refractory disease

A

Brentuximab -CD 30 directed antibody

41
Q

How can you evaluate response to treatment

A 
Clinical examination 
Abnormal investigation 
Évaluation after 3-4 courses of chemotherapy 
Palpation for masses, lymph noes
Pet scan for residual disease
42
Q

Percentage of patients with Hodgkin lymphoma that can be cured

A

85%

Hematology (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions