Non Hodgkin Lymphoma

Question 1

Compare age distribution of Hodgkin lymphoma to non Hodgkin lymphoma

Answer 1

Hodgkin lymphoma => bimodal 15-35 and above 50

Non Hodgkin lymphoma => more than 50 yo

Question 2

Compare male to female ratio in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 2

Hodgkin lymphoma => 5:1 for male

Non Hodgkin lymphoma => 1.7:1 for male

Question 3

Compare stage of presentation in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 3

Hodgkin lymphoma => I and II

Non Hodgkin lymphoma => III and IV

Question 4

Compare percentage of B symptoms in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 4

Hodgkin lymphoma => 25-40%

Non Hodgkin lymphoma => 15%

Question 5

Compare spread of disease in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 5

Hodgkin lymphoma => predictable centripetal or axial spread to contiguous lymph nodes

Non Hodgkin lymphoma => random spread

Question 6

Compare leukemia phase presence in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 6

Hodgkin lymphoma => rare

Non Hodgkin lymphoma => common

Question 7

Compare percentage of nodal and extranodal origin tumor in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 7

Hodgkin lymphoma => more than 95% nodal in origin

Non Hodgkin lymphoma => 80% nodal , 20% extranodal

Question 8

Compare involvement or not of Trochlear , mesenteric or pharyngeal nodes in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 8

Hodgkin lymphoma => rare

Non Hodgkin lymphoma => common

Question 9

Compare mediastinal involvement percentage in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 9

Hodgkin lymphoma => 50%

Non Hodgkin lymphoma => 20%

Question 10

Compare bone marrow involvement percentage in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 10

Hodgkin lymphoma => less than 10%

Non Hodgkin lymphoma => 70%

Question 11

Compared GIT and liver involvement in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 11

Hodgkin lymphoma => rare

Non Hodgkin lymphoma => commoner

Question 12

Compre contiguous spread or not from lymph nodes in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 12

Hodgkin lymphoma => yes

Non Hodgkin lymphoma => no

Question 13

Compare superior vena cava oncstruction in Hodgkin lymphoma and non Hodgkin lymphoma

Answer 13

Hodgkin lymphoma => rare

Non Hodgkin lymphoma => common

Question 14

Do we know etiology of non Hodgkin lymphoma

Answer 14

No

Question 15

Factors that play role in non Hodgkin lymphoma

Answer 15

EBV
HTLV1
Immunosupression

Question 16

2 types of cellular infection by EBV

Answer 16

Latent

Cellular

Question 17

Which type of EBV infection linked with non Hodgkin lymphoma

Answer 17

Latent

Question 18

Three types of EBV latency with genes and disease entity caused

Answer 18

Question 19

Types of non Hodgkin lymphoma

Answer 19

Aggressive
Indolent
B cells lymphomas
T cell lymphomas

Question 20

Aggressive non Hodgkin lymphoma types

Answer 20

Diffuse large B cell lymphoma 
Anaplastic large cell lymphoma 
Burkitt lymphoma 
Lymphoblastic lymphoma 
Mantle cell lymphoma 
Peripheral T cell lymphoma

Question 21

Indolent non Hodgkin lymphoma types

Answer 21

Follicular lymphoma 
Cutaneous T cell lymphoma 
Lymphoplasmacytic lymphoma 
Marginal zone B cell lymphoma 
MALT lymphoma 
Small cell lymphocytic lymphoma

Question 22

B cell lymphoma types

Answer 22

Diffuse large B cell lymphoma 
Follicular lymphoma 
Mantle cell lymphoma 
Marginal zone lymphoma 
Burkitt lymphoma 
Lymphoplasmcytic lymphoma

Question 23

T cell lymphomas

Answer 23

Cutaneous T cell lymphomas
Angioimmunoblastic T cell lymphoma
Anaplastic large cell lymphoma
Enteropathy type T cell lymphoma

Question 24

Can we use same staging of Hodgkin lymphoma in non Hodgkin lymphoma

Answer 24

Yes

Question 25

Investigations in non Hodgkin lymphoma

Answer 25

Waldeyer group of LNs inspection Bone biopsy Laparotomy sometimes

Question 26

To say that there’s positive LN involvement , what size shou you measure

Answer 26

More than 1.5 cm

Question 27

How do you attest spleen involvement

Answer 27

Imaging

Question 28

How do you determine intrathoracic involvement

Answer 28

CX ray

Question 29

How do you determine chest, abdomen, pelvis involvement

Answer 29

CT

Question 30

How do you identify abnormal LN

Answer 30

Lymphangiography

Question 31

How do you identify bone disease and card compression

Answer 31

MRI

Question 32

Clinical features

Answer 32

Widespread painless LN Hepatosplenomegaly 20-30% with B presentation

Question 33

Main extranodal disease in Burkitt lymphoma

Answer 33

Jaw in Africa | GIT and other abdominal sites in West

Question 34

Symptoms of lymphoblastic lymphoma

Answer 34

Thymic mass Systemic symptoms Bone marrow failure

Question 35

Management of non Hodgkin lymphoma based on type ?

Answer 35

Yes

Question 36

Do half of patient that experienced complete remission from non Hodgkin lymphoma relapse in 5 years

Answer 36

Yes

Question 37

Treatment in advanced disease

Answer 37

Anthracycline containing regimen Fludarabine based regiment

Question 38

Can you repeat combination therapy if failure

Answer 38

Yes after Long period of remission