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Flashcards in Hypersensitivities and Immunopathologies Deck (39)
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1

** Type I HS involves _________ antibodies

IgE

2

** Type II HS involves _________ antibodies (2)

IgM
IgG

3

** Type III HS involves _________ antibodies (2)

IgM
IgG

4

** Type IV HS involves _________ cells

T cells

5

Which type of HS is ANTIBODY mediated?

Type II

6

Which Type of HS is IMMEDIATE (allergic)?

Type I

7

Which type of HS is IMMUNE COMPLEX mediated?

Type III

8

Which type of HS is CELL mediated?

Type IV

9

** ALL forms of HS require _________

prior exposure to the antigen

10

HS can target SELF antigens OR FOREIGN antigens

T/F

True

11

** Type I HS is associated with _________

allergies

12

About _________ of the population suffers from type I HS

54%

13

In type I HS, Helper T cells are activated and differentiate to the _________ subtype

Th2

14

APC presents peptide to the allergen on _________ molecules in Type I HS

MHC II

15

In type I HS, IgE antibodies that are attached to _________ have a half life of several weeks

mast cells

16

_________ associated with ALLERGIES are located in the tissues and have receptors for the Fc region of IgE

mast cells

17

In allergies, _________ are brought into the tissue from the blood by signals sent by the MAST CELLS for RAPID release

basophils

18

In allergies, _________ are recruited from the BONE MARROW and have a DELAYED response

eosinophils

19

People who are _________ produce large quantities of IgE

atopic

20

People who are NON-Atopic produce mainly _________ antibodies

IgG

21

Type II HS does NOT involve _________ antibodies

IgE

(involves IgG and IgM)

22

Antibody dependent cell-mediated cytotoxicity (ADCC) is associated with _________ HS

Type II

23

ADCC cells (type II HS) are COMPLEMENT _________

independent

24

In type II HS, _________ and _________ antibodies are good at FIXING THE COMPLEMENT

IgM
IgG

(Me Good at fixing complement)

25

In type II HS, antibodies bind to carbs or proteins present on RBCs that are PHAGOCYTIZED, this is known as _________

hemolytic anemias

26

RHEUMATIC HEART DISEASE where streptococcal throat infection activated Helper T cells is an example of _________ HS

Type II

27

** Deposition of antibodies and antigen complexes causing INFLAMMATION (vasculitis) is associated with _________ HS

Type III

28

In type III HS, complement attracts _________ and _________

neutrophils
macrophages

29

LUPAS is an INFLAMMATORY disease which is usually (90%) found in women that exhibits B and T cell INTOLERANCE and is an example of _________ HS

Type III

30

Delayed Type Hypersensitivity (DTH) and Cell Mediated Cytotoxicity are two types of _________ HS

type IV