Hypersensitivity reactions

Question 1

type 1 hypersensitivity reaction

Answer 1

immediate, IgE-mediated, mild or severe
prurititis, urticaria, facial edema, anaphylaxis
includes skin/food allergies, asthma, insect bites, drug reactions, vaccine reactions

Question 2

type 2 hypersensitivity reaction

Answer 2

Ab binds to Ag located on the surface of cells resulting in cell lysis or phagocytosis
immune-mediated anemia/thrombocytopenia, vasculitis, skin disease (pemphigus)

Question 3

type 3 hypersensitivity reaction

Answer 3

Ag-Ab (circulating immune) complexes that cause acute inflammation in tissues
joints, skin, kidneys, lungs, brain, erythema multiforme, types of vasculitis, pneumonitis, glomerulonephritis, rheumatoid/polyarthritis

Question 4

type 4 hypersensitivity reaction

Answer 4

T cell-mediated immune reactions that provoke an inflammatory reaction against Ags, delayed-type (may take days)
allergic contact hypersensitivity