Hypersensitivity Responses I Flashcards
(27 cards)
What type of hypersensitivity response occurs due to a PPD test?
Type IV (Delayed type hypersensitivity)
What induces the inflammatory response associated with a PPD test?
Sensitized T cells.
What type of hypersensitivity response occurs due to atopy (urticaria, asthma, allergic rhinitis)?
Type I (anaphylaxis)
What type of hypersensitivity response causes anaphylactic shock?
Type I
What type of hypersensitivity response is associated with hemolytic disease of the newborn?
Type II
What type of hypersensitivity response is associated with transfusion reactions?
Type II
What type of hypersensitivity response is associated with Goodpasture’s syndrome
Type II
What types of hypersensitivity response are associated with Glomerulonephritis?
Type II, III
What type of hypersensitivity response is associated with an arthus reaction?
Type III
What type of hypersensitivity response is associated with serum sickness?
Type III
What type of hypersensitivity response is associated with Polyarteritis nodosa?
Type III
What type of hypersensitivity response is associated with SLE?
Type III
What type of hypersensitivity response is associated with RA?
Type III
What type of hypersensitivity response is associated with Tuberculosis?
Type IV
What type of hypersensitivity response is associated with granulomatous reactions?
Type IV
What type of hypersensitivity response is associated with contact dermatitis?
Type IV
What condition is associated with Polyarteritis nodosa?
Hepatitis B.
What reactions characterize a Type I hypersensitivity response?
Anaphylaxis and atopic responses (p.203)
Describe the antigen response to a type I hypersensitivity reaction.
Free antigen crosslinks IgE on presensitized mast cells and basophils triggering the release of vasoactive amines that act at postcapillary venules (i.e. histamine) (p.203)
How quickly does a type I hypersensitivity reaction occur?
The reaction develops rapidly/ immediately after antigen exposure due to preformed antibody (p.203)
What do Types I, II, and III Hypersensitivity reactions all have in common?
They are all antibody mediated (p.203)
What test can be used to diagnose a type I hypersensitivity reaction?
A skin test specific for IgE (p.203)
Describe the antigen response to a type II hypersensitivity reaction.
Cytotoxic, antibody mediated response. IgM and IgG bind to a fixed antigen on an enemy cell which leads to cellular destruction (p.203)
What are the three mechanisms responsible for generating a type II hypersensitivity reaction?
Opsonization (leads to phagocytosis or complement activation), complement mediated lysis, antibody-dependent cell-mediated cytotoxicity (ADCC) usually due to NK cells (p.203)
