Flashcards in Cytokines, Interferons, Cell Surface Molecules II Deck (26)
What CD markers are ubiquitous to all cells?
What CD marker is expressed exclusively by NK cells?
What CD cell type mediated leukocyte adhesion and rolling interaction with the endothelium?
Which cell types possess CD82L?
B cells, T cells, monocytes, NK cells.
What CD cell type is a high affinity receptor for IgG?
What CD cell type is a receptor for IgA?
What CD cell type is ubiquitous to all proliferating (i.e. activated cells)?
What CD cell type is unique to lymphocytes?
What type of cells express CD80 antigens?
What cell marker is used to count T cells?
What cell markers are used to count B cells?
Membrane bound IgM, CD19, CD20.
A deficiency in what CD cell type is associated with Leukocyte Adhesion Deficiency?
What important cytokines are secreted by macrophages?
IL-1, IL-6, IL-8, IL-12, TNFa (p.200)
Name four functions of IL-1.
1.) endogenous pyrogen- causes fever; 2.) causes acute inflammation; 3.) activates endothelium to express adhesion molecules; 4.) induces chemokine secretion to recruit leukocytes (p.200)
What is the function of IL-6?
An endogenous pyrogen that causes fever and stimulates production of acute phase proteins (p.200)
What cell type secretes IL-6?
Th2 cells (p.200)
Describe the principle functions of cytokines IL-1 through IL-5.
(Hot T-Bone stEAk) IL-1: fever (hot); IL-2: stimulates T cells; IL-3: stimulates Bone marrow; IL-4: stimulates IgE production; IL-5: stimulates IgA production (p.200)
What is the major function of IL-8?
IL-8 is the major chemotactic factor for neutrophils; IL-8 helps clear infections (p.200)
What are the two major functions of IL-12?
To induce differentiation of T cells into Th1 cells and to activate NK cells (p.200)
What cell type secretes IL-12?
IL-12 is secreted by B cells (p.200)
What are the four major functions of TNF-a?
Mediation of septic shock, activation of endothelium, leukocyte recruitment, vascular leak (p.200)
What two cytokines are secreted by all T cells?
IL-2 and IL-3 (p.200)
From where is IFN-y secreted?
From Th1 cells (p.200)
What is secreted from Th2 cells?
IL-4, IL-5, IL-10, IL-13 (p.200)
What is the function of IL-2?
Stimulates growth of helper, cytotoxic, and regulatory T cells (p.200)