Flashcards in Cytokines, Interferons, Cell Surface Molecules III Deck (26)
What does IFN-y activate?
Activates macrophages and Th1 cells (p.200)
What does IFN-y suppress?
Suppresses Th2 cells (p.200)
Name two properties if IFN-y.
Antiviral and antitumor properties (p.200)
Name three functions of IL-4.
1.) induces differentiation into Th2 cells; 2.) Promotes growth of B cells; 3.) enhances class switching to IgE and IgG (p.200)
Name three functions of IL-5.
1.) promotes differentiation of B cells; 2.) enhances class switching to IgA; 3.) stimulates growth and differentiation of eosinophils (p.200)
Name two functions of IL-10.
1.) modulates the inflammatory response; 2.) Inhibits actions of activated T cells and Th1
What two cell types secrete IL-10?
Th2 cells and regulatory T cells (p.200)
What cytokine has similar actions to IL-10 and why?
TGF-b. Both are involved in inhibiting inflammation (p.200)
What is an interferon?
A protein that places uninfected cells in an antiviral state (p.201)
Name the three types of interferons.
IFN-a, IFN-b, IFN-y (p.201)
What is the mechanism of action for interferon response to viruses?
Interferons induce the production of a ribonuclease that inhibits viral protein synthesis by degrading viral mRNA without degrading host mRNA. They also activate NK cells to kill virus infected cells (p.201)
What is the specific function of a and b interferons?
They inhibit viral protein synthesis (p.201)
What is the specific function of y interferons?
To increase MHC I and II expression and antigen presentation in all cells (p.201)
What type of cell is the only type of cell that does not carry MHC I?
Mature red blood cells (p.201)
To what does TCR bind?
Antigen- MHC complexes (p.201)
In what way is CD3 related to TCR?
They both participate in signal transduction (p.201)
What does CD28 bind?
B7 on APC (p.201)
What class of cells express CD40 ligand?
Helper T cells (p.201)
What do immunoglobulins bind?
What is the CD receptor for EBV?
Name four cell surface proteins expressed by B cells.
CD19, CD20, CD21, CD40 (p.201)
What two cell surface proteins are carried by macrophages?
CD14, CD40 (p.201)
What cell surface marker is unique for NK cells?
What cell surface markers do NK cells have?
CD16 (that binds Fc of IgG), and CD56 (p.201)
Under what conditions are T cells anergic?
Self reactive T cells become nonreactive without a costimulatory molecule (p.201)