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CVR Biweekly 2 > Hypertension Drugs > Flashcards

Hypertension Drugs Flashcards

(55 cards)

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1
Q

treat for HTN w/ BP > than what #

A

130 mmHg

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2
Q

1st line treatment for HTN

A

CCB (Ca2+ channel blockers)

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3
Q

4 types of drugs used to treat HTN

A

CCB’s
+
ARBs/ACEIs
+/- Thiazides
+/- Statins

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4
Q

Dihydropyridines
Nondihydropyridines

A

CCB’s

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5
Q

RAA drugs

A

ARBs
ACEIs

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6
Q

type of drugs used to treat DIFFICULT hypertension

A

K+ sparing diuretics

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7
Q

aldosterone antagonists
ENaC blockers

A

K+ sparing diuretics

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8
Q

most prescribed dihydropyridine for HTN

A

Amlodipine

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9
Q

short-acting dihydropyridine that should not be used long term b/c can lead to MI and death

A

Nifedipine

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10
Q

drugs ending in -PINE (used to treat HTN)

A

Dihydropyridines

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11
Q

DILTIAZEM

A

nondihydropyridine to treat HTN

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12
Q

most effective drug class for primary prevention of stroke

A

CCB’s

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13
Q

what compromises effectiveness of ARBs, ACEIs, and diuretics

A

high salt diet or NSAIDs

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14
Q

what does not compromise effectiveness of CCBs

A

high salt diet or NSAIDs

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15
Q

SE for CCB’s; and how to help it

A

ankle edema; add ARBs

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16
Q

all______ can depress SA node

A

CCB’s

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17
Q

main problem with HTN

A

visceral adipocytes producing leptin

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18
Q

target is POMC neurons and signal transmitted to IML (increase sympathetics, increase bp)

A

Leptin

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19
Q

effects of leptin

A

increase cAMP, RAS, vasoconstriction, afterload, HTN, LV workload

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20
Q

how can Ang II and aldosterone make HTN worse

A

Ang II increases aldosterone; more Na+ and water reabsorption; increase blood volume makes HTN worse

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21
Q

ultimately decreases size of lumen and therefore vasoconstricts

A

maladaptive remodeling

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22
Q

what can ultimately happen from Ang II effects

A

heart failure

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23
Q

effects of aldosterone

Study These Flashcards
A

increases ENaC expression
increases Na+ and water reabsorption

24
Q

AT1R (Gq)

Study These Flashcards
A

vasoconstriction

25
AT2R (Gi)
vasodilation
26
renin inhibitor (blocks effects of whole process)
ALISKIREN
27
Aldosterone receptor blockers
Spironolactone eplerenone
28
(-PRIL); ACEIs (oldest drugs)
Lisinopril....
29
AT1R blockers(Gq) [-SARTAN]
Losartan Valsartan
30
don't use ARBs and ACEIs along with this drug
AZILSARTAN
31
ACEIs/ARB/DRI contraindications
1. bilateral renal artery stenosis 2. PREGNANCY (teratogens) 3. renal failure
32
what labs to order when you start patient on ACEIs
CREATININE
33
FUROSEMIDE TORSEMIDE BUMETANIDE ETHACRYNIC ACID
loop diuretics
34
CHLORTHALIDONE HCTZ METOLAZONE INDAPAMIDE
Thiazide/thiazide-like drugs
35
where do loop diuretics act on
Thick Ascending Loop
36
act on NKCC2 and lead to excretion of Na+, K+, Cl-, Ca2+, Mg2+
loop diuretics
37
NSAIDs block effect of this drug
Loop diuretics
38
only used for special cases when treating HTN
loop diuretics
39
SE of loop diuretics
ototoxicity
40
blocks NCC and keeps Ca2+ in blood
Thiazide diuretics
41
all sorts of edema can be treated w/ this drug
thiazide diuretics
42
used for kidney stones(limits Ca2+ in urine) and osteoporosis (bone health)
thiazide diuretics
43
contraindicated in Gout
Thiazides
44
better thiazide than HCTZ these days
CHLORTHALIDONE
45
K+ sparing Diuretics (Na+ still excreted)
ENaC blockers Aldosterone receptor blockers
46
Amiloride Triamterene
ENaC blockers
47
K+ sparing drug that antagonizes both MR(aldosterone) and AR (androgen)
Spironolactone
48
only use for DIFFICULT HTN and after trying MR blocking and ENaC blocking drugs
B blockers (-LOL)
49
Labetalol Carvedilol Nebivolol
block B1 and a1
50
-LOL that stimulates NO production
Nebivolol
51
a1 blockers used to treat pheochromocytoma
phenoxybenzamine phentolamine
52
what can happen when trying to take patient off of HTN meds
rebound HTN
53
Hydralazine Procainamide (both can cause what)
cause drug induced LUPUS
54
long acting VIP for HTN
Vasomera
55
what must be discontinued if patient has HTN but becomes pregnant
RAA blockers

CVR Biweekly 2 (15 decks)

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