Hypogonadism Flashcards Preview

ADT Module 5-8 > Hypogonadism > Flashcards

Flashcards in Hypogonadism Deck (31)
1

___ is a clinical syndrome that results from failure of teh testis to produce physiological levels of ___ and a normal number of ___ d/t disruption of one or more levels of the hypothalamic-pituitary-testicular (HPT) axis.

hypogonadism, testosterone, spermatozoa

2

Symptoms of primary hypogonadism is more common with testosterone levels < ___ and increased ___ and ___.

300, luteinizing hormone (LH) and follicle-stimulating hormone (FSH)

3

Congenital causes of hypogonadism include: ___ syndrome and congenital ___ ___.

Kleinfelter's, adrenal hyperplasia

4

Symptoms of secondary hypogonadism portrays ___ testosterone and ___ LH/FSH.

decreased, decreased

5

Drugs such as ___, ___, and ___ can cause secondary hypogonadism.

opiates, glucocorticoids, androgens

6

Drugs such as ___, ___, and ___ can cause primary hypogonadism.

ETOH, ketoconazole, chemorx

7

Symptoms of hypogonadism include: ___ libido, ___ erections, ___, loss of body ___, shrinking ___, inability to ___, ___ loss, hot ___/sweats.

decreased, decreased, hair, testes, conceive, height, flushes

8

When to test for hypogonadism: if they have a ___ mass, have been on long-term tx w/meds that affect ___ production, ___-associated wt loss, ___, ___, ___ or low trauma fracture.

sellar, testosterone, HIV, ESRD, infertility, osteoporosis

9

It is best to test testosterone levels in the ___ b/c they are at their highest.

morning

10

Contraindications for testosterone therapy include:

prostate or breast carcinoma, urinary symptoms d/t BPH, polycythemia

11

Goals of testosterone therapy is to: improve ___ function and restore ___, increase ___ mass and ___, increase ___ density and reduce the risk for ___, improve ___, and increase ___.

sexual, libido, muscle, strength, bone, fractures, energy, hematocrit

12

Achieve testosterone levels in range of ___-___.

350-750

13

Adverse effects of testosterone therapy include: ___, ___ or oily skin, reduced ___ production.

erythrocytosis, acne, sperm

14

First-line tx for hypogonadism is ___. May also use testosterone ___ and ___ as second-line tx.

testosterone cypionate (depo-testosterone), patches, gels

15

If going w/patches, apply to non-___ areas.

pressure

16

Testosterone patches include:

androderm and testoderm

17

Testosterone gels include:

androgel

18

Disadvantage of testosterone gel/patches is that it must be applied ___.

daily

19

___ is a transbucal testosterone patch applied to the upper ___ every ___ hrs.

Striant, gum, 12

20

Testosterone pellets are implanted via ___ and need to be changed out every ___-___ months.

SQ, 3-6

21

All tx's that apply to primary hypogonadism also applied to ___ hypogonadism.

secondary

22

Exogenous testosterone decreases chance of ___. The medication ___ ___ preserves fertility.

fertility, clomphene citrate

23

Clomphene citrate (aka ____ is used in the tx for ___ hypogonadism. It works by blocking pituitary ___ receptors, and also increases ___ and ___ which stimulates testicular function.

clomid, secondary, estrogen, LH, FSH

24

Check testosterone levels every ___-___ wks after initiating tx. Goal of levels should be: ___-___.

4-6, 350-800

25

Once testosterone levels are stable and in target range, monitor every ___-___ months, and check ___ and ___ annually.

6-12, hematocrit, PSA

26

Primary is d/t ___ failure. Secondary is d/t ___ deficiency.

testicular, gonadotropin (LH/FSH)

27

Gynecomastia is an indicator of ___.

hypogonadism

28

Need to check a ___ level before starting on testosterone therapy. Goal of ___ or less.

PSA, 4

29

Testosterone therapy is always given through the ___. Never given orally b/c it is potentially ___.

skin, hepatotoxic

30

Greater tendency of ___ when you take IM testosterone d/t greater fluctuations

erythrocytosis

31

Gonadotropins include ___ and ___.

LH, FSH