Parkinson's/RLS Flashcards Preview

ADT Module 5-8 > Parkinson's/RLS > Flashcards

Flashcards in Parkinson's/RLS Deck (28)
1

Gold standard for Parkinson's is ___ (aka Sinemet).

carbidopa/levodopa

2

Long-term use of carbidopa/levodopa can l/t ___.

dyskinesia

3

Meds used to tx PD:

levodopa/carbidopa, dopamine agonists, COMT inhibitors, MAO selective inhibitors, amantadine, anticholinergics

4

Dopamine agonists have potential for ___ behaviors.

compulsive

5

MAO inhibitor includes: ___. Metabolites are amphetamine, so can cause ___ if taken later in day. Wait ___ wks before starting on another med.

Selegiline, insomnia, 2

6

COMT inhibitors include:

tolcapone, entacapone

7

Tolcapone has risk of ___, so monitor ___. Take ___ before or after meals at same time each day.

hepatotoxicity, LFT, 2

8

Entacapone has a ___ onset and ___ duration.

quick, short

9

___ is used as adjunctive therapy w/COMT, MAO inhibitors, carbidopa/levodopa if pt's continue to have ___.

Amantadine, tremors

10

___ can also be used as adjunctive therapy for PD tx and is useful for ___. Avoid in ___ d/t urinary retention and confusion. May be difficult to ___ once started.

Anticholinergics, tremors, elderly, withdraw

11

From lowest to strongest potency:

MAO inhibitors, dopamine agonists, carbidopa/levodopa

12

Peripheral dopaminergic s/e include:

n/v/d, orthostatic hypotension

13

Central dopaminergic s/e include:

insomnia, somnolence, sleep attacks, hallucinations, psychosis, nightmares

14

Levodopa/carbidopa may interact w/___.

iron/ferrous sulfate

15

Avoid ___ w/dystonia.

CR

16

D-I-D represents ___ of disease.

progression

17

Nonmotor symptoms may include:

erectile dysfunction, orthostatic hypotension, urinary incont, constipation, excessive daytime sleepiness, insomnia, periodic limb movements of sleep, fatigue, REM sleep behavior disorder, anxiety

18

For cognitive-related PD, tx dementia w/___.

rivastigmine

19

Atypical antipsych's to use in PD include:

quietiapine, clozapine, ariprazole

20

___ and ___ are shown to be effective in tx'ing essential tremors.

Propranolol, primidine

21

Tx for RLS is similar to that of ___.

PD

22

Nonpharmacologic tx for RLS includes: ___ activities, stopping ___/___/___, supplementing w/___ if deficient.

alerting, caffeine, nicotine, alcohol, iron

23

Most common cause of RLS is ___ deficiency.

iron

24

70% of pts who use carbidopa/levodopa experience ___ of RLS symptoms, which is known as ___. Tx is to ___ the dose and change meds.

worsening, augmentation, decrease

25

Both ___ and ___ stimulation alleviate the symptoms of RLS.

physical, mental

26

Any pt w/a plasma ferritin concentration < 50mcg and have RLS symptoms should be started on an ___ ___.

iron replacement

27

___/___ is a good choice for pt's w/intermittent symptoms b/c it can be taken on a ___ basis.

carbidopa/levodopa, PRN

28

___ is effective in tx'ing tremors.

propranolol