PUD

Question 1

There is a 4x greater incidence of ___ ulcers than ___ ulcers.

Answer 1

duodenal, gastric

Question 2

___ ulcers tend to peak in older pts.

Answer 2

gastric

Question 3

___ ulcers take about 2 wks longer to heal.

Answer 3

gastric

Question 4

Goal w/PUD is to eradicate ___.

Answer 4

H. Pylori

Question 5

___ is the predominant factor for recurrent ulcers, but others include:

Answer 5

H. Pylori, smoking, NSAIDS, hypersecretion, noncompliance

Question 6

Tx for H. Pylori is ___ antibx + a ___ or ___ antagonist.

Answer 6

2, PPI, H2

Question 7

First-line tx for H. Pylori is: ___. Total of ___ pills per day. Take for ___ wks.

Answer 7

Amoxicillin OR Tetracycline + Flagyl + PPI (or H2), 15, 2

Question 8

Examples of H2 antagonists:

Answer 8

ranitidine (zantac), cimetidine (tagamet), nizatadine (Axid), famotidine (pepcid)

Question 9

Ideal duration of tx for duodenal ulcers is ___-___wks, ___-___ wks for gastric, and ___-___ wks for older pt or smoker.

Answer 9

4-6, 8-12, 6-8

Question 10

DOC for H2 antagonists is ___.

Answer 10

famotidine (pepcid)

Question 11

Purpose of H2’s is to ___ histamine receptors and block ___.

Answer 11

block, acid

Question 12

Purpose of antacids is not to block acid, but to ___ it. Used for ___ symptom relief.

Answer 12

neutralize, PRN

Question 13

Examples of antacids include:

Answer 13

Calcium carbonate (TUMS), Mylanta, Maalox

Question 14

Limit use of ___ ___ d/t rebound acid effect.

Answer 14

calcium carbonate

Question 15

The medication ___ binds to and protects ulcers from acid and allows for healing of the ulcer.

Answer 15

sucralfate (carafate)

Question 16

DOC for pregnancy is ___ d/t its nonsystemic effects.

Answer 16

sucralfate

Question 17

Cytoprotective agents include:

Answer 17

sucralfate (Carafate), misoprostil (Cytotec), bismuth salts (Pepto-Bismol)

Question 18

___ has antibx effects against H. Pylori and is therefore used in the combination of tx.

Answer 18

bismuth

Question 19

Proton Pump Inhibitors (PPI’s) include:

Answer 19

omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), Nexium

Question 20

PPI’s have a dramatic ___ in gastric acid by interfering w/the ___/proton pump.

Answer 20

reduction, ATP-ase

Question 21

PPI’s should be used for ___-___ wks and heal ulcers ___ than H2’s.

Answer 21

4-8, faster

Question 22

Avoid use of ___ while on PPI’s d/t drug interaction.

Answer 22

ketoconazole

Question 23

___ are the DOC for tx AND prophylaxis of PUD. They heal ___ than H2’s.

Answer 23

PPI’s, faster

Question 24

___ are DOC for NSAID-induced ulcers.

Answer 24

PPI’s

Question 25

Monitor ___ effects and ___ effects w/H2's.

Answer 25

renal, CNS

Question 26

___ is the only way to conclusively select between GU and DU.

Answer 26

Endoscopy

Question 27

General tx includes: stop ___, minimize ___ use, and avoid ___ foods.

Answer 27

smoking, alcohol, exacerbating

Question 28

Dx H. Pylori w/___.

Answer 28

biopsy

Question 29

H. Pylori needs an ___ environment to live and thrive.

Answer 29

acidic

Question 30

Low pH indicates an ___ environment. High pH indicates an ___ environment.

Answer 30

acidic, alkaline

Question 31

MOC stands for: | MOA stand for:

Answer 31

metronidazole, omeprazole, clarithromycin | metronidazole, omeprazole, amoxicillin

Question 32

It is equipotent whether you give your entire dosing once dly or if you split it up for ___. Whereas, it might be more effective split up for ___.

Answer 32

PUD, GERD

Question 33

Misoprostil (Cytotec) is used for ___-induced gastric ulcers.

Answer 33

NSAID

Question 34

PPI's block ___ acid pathways of acid, gastrin, and pepsin. H2's do not.

Answer 34

ALL

Question 35

___ pump is also known as the proton pump.

Answer 35

ATP-ase

Question 36

Don't combine ___ w/H2's.

Answer 36

PPI's