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Flashcards in Hypothalamus/PG Deck (17)
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1

A pituitary adenoma that causes excess GH

Acromegaly/Gigantism

2

Clinical Signs of Acromegaly/Gigantism

Enlargement of hands and feet
Increased ring, glove and shoe size
Coarsening of facial features
Enlargement of internal organs
Metabolic – glucose intolerance
Sleep apnea
Increased incidence of colon polyps and canc

3

Effects of Acromegaly/Gigantism:

Hypopituitarism
HTN
Glucose intolerance or DM
Cardiac enlargement
Cardiac failure

4

Treatment of Acromegaly/Gigantism

Surgery to remove pituitary adenoma

5

GH Deficiency before Epiphyses Close

Dwarfism

6

Clinical Signs of Dwarfism

Characteristic growth patterns include normal birth length and height, with a gradual decrease in percentiles of height for age by 2 years

7

Diagnosing Dwarfism

All other causes of decreased growth must be considered and ruled out before this diagnosis can be made with confidence.

8

ADH Deficiency can cause this

Diabetes Insipitus

9

Clinical Signs of Diabetes Insipitus

Polyuria with intense thirst for ice cold water

10

Risks with Diabetes Insipitus

Hypernatremia due to high levels of excretion in the urine

11

Treatment of Diabetes Insipitus

Mild: Adequate hydration
Moderate: Desmopressin to achieve homeostasis

12

Excessive Release of ADH from Neurohypophysis can cause

Syndrome of Inappropriate ADH Secretion (SIADH)

13

What can cause SIADH?

Trauma
Stress
Tumors
CNS Disorders

14

Prolactin Secreting Pituitary Adenoma

Prolactinoma

15

Clinical Features of Prolactinoma

Amenorrhea
Menstrual irregularities
Infertility
Loss of potency and libido in men
Visual loss
Headaches

16

How to diagnose Prolactinoma

Prolactin levels are elevated, confirmed with MRI of Pituitary

17

Treatment of Prolactinoma

Dopamine agonists (Bromocriptine or Cabergoline)
If the patient cannot tolerate D.A. or the tumor is notresponding to D.A. with compressive symptoms - trans-sphenoidal surgery
Radiation Therapy