Insulin Therapy Flashcards Preview

Med 1 Endo > Insulin Therapy > Flashcards

Flashcards in Insulin Therapy Deck (41)
Loading flashcards...

If a patient comes in presenting with Diabetic Ketoacidosis, what should you do.

Monitor them frequently!


A patient with diabetes needs what type of treatment in regards to fluid and insulin.

Aggressive treatment if fluid deficit

Non-aggressive treatment of insulin (hypoglycemic episodes can occur with too much insulin)


Factors to consider when putting a patient on Insulin Therapy:

1. Cost
2. Lifestyle
3. Compliance
4. Patient Education
5. Social Support


What types of Insulin therapy are there?

1. Syringe
2. Pen
3. Continuous Pump
4. Inhaled (coming soon)


Where do you normally administer insulin (for optimal results)?

Outer Thigh


What are three "rapid-acting" insulins on the market?

1. Humalog
2. Novolog
3. Apidra


What is the benefit of combining insulin drugs (synergy)?

Helps non-compliant patients with their hyperglycemia


What is the disadvantage of combining insulin drugs (synergy)?

Increased risk for hypoglycemia
Weight gain possible


When should we use a concentrated insulin? (U500)

Patients with very high insulin resistance


Rapid Acting Insulin: Onset, Peak, Duration

Onset: 15 minutes
Peak: 30-90 minutes
Duration: 3-5 hours


Regular Insulin: Onset, Peak, Duration

Onset: 30 min - 1 hour
Peak: 2 hours
Duration: 6 hours


NPH (Humilin): Onset, Peak, Duration

Onset: 1-2 hours
Peak: 6-8 hours
Duration: 10-16 hours


Lantus/Levemir Insulin: Onset, Peak, Duration

Onset: 1 hour
Peak: None
Duration: 24 hours


What could cause hyperglycemia when you wake up?

Silent Hypoglycemia in the evening that rebounds in the morning


What is the Somogyi Effect?

The Somogyi effect can occur when a person takes long-acting insulin for diabetes. If the blood sugar level drops too low in the early morning hours, hormones (such as growth hormone, cortisol, and catecholamines) are released. These help reverse the low blood sugar level but may lead to blood sugar levels that are higher than normal in the morning. An example of the Somogyi effect is:

- A person who takes insulin doesn't eat a regular bedtime snack, and the person's blood sugar level drops during the night.

- A person's body responds to the low blood sugar in the same way as in the dawn phenomenon, by causing a high blood sugar level in the early morning.


What is the Dawn Phenomenon?

Hormones (growth hormone, cortisol, and catecholamines) produced by the body cause the liver to release large amounts of sugar (glucose) into the bloodstream. These hormones are released in the early morning hours. These hormones also may partially block the effect of insulin, whether it's insulin your body produces or insulin from the last injection.

This can happen in anyone, but when there is insulin resistance, this will cause a bad effect.


How to tell the difference between Somogy and Dawn?

The Somogyi effect can occur any time you or your child has extra insulin in the body. To sort out whether an early morning high blood sugar level is caused by the dawn phenomenon or Somogyi effect, check blood sugar levels around 2 a.m. to 3 a.m. for several nights.

If the blood sugar level is low at 2 a.m. to 3 a.m., suspect the Somogyi effect.
If the blood sugar level is normal or high at 2 a.m. to 3 a.m., it's likely the dawn phenomenon.


How do you dose insulin?

1. Depends on patient's weight
2. Estimate the total daily dosage (TDD) and how it's being administered (shots vs. pump)


Calculating Dosage

Rule of 500: (carb:insulin ratio) 500/TDD

Rule of 1800: (sensitivity/correction factor) 1800/TDD


What does the Rule of 500 tell us?

Can use for calculating amount of meal-time insulin needed


What does the Rule of 1800 tell us?

(When Jose is missing, 1800 is where it's at)

Tells the amount of change in blood glucose from 1 unit of insulin


What are the goals of treating DM

1. Getting A1C below 7%
2. Less/Shorter Glycemic Excursions


If this condition associated with DM is untreated it could be fatal.

Diabetic Ketoacidosis


What causes DKA (Diabetic Ketoacidosis)?



How can you become DKA

Having insulin deficiency results in excess free fatty acids from adipose tissue.
These FAs are substrates for ketone production in the liver


How does DKA present?

1. Acidosis
2. Elevated Anion Gap
3. Low glucose
4. Serum and urine ketones are elevates
5. Mental Health Status is Variable


Clinical Features of DKA

1. Polyuria, Polydipsia
2. Hyperventilation (deep, rapid breaths (Kussmauls))
3. Sweet Smelling Breath
4. Hypokalemia


What Labs would you order to check for DKA?

Blood cultures
Drug Screen
Urine Culture


How would you treat DKA?

1. IVF hydration
2. Electrolyte replacement
3. Unsilun
4. Potential bicar therapy in DKA if pH<6.9
5. Eval underlying dz


What is the goal of Treatment for DKA?

1. Suppress Release of Free Fatty Acids and the Production of Ketones
2. Suppress Liver Production of Glucose