Immune System Flashcards

(50 cards)

1
Q

Function of immune system

A

Protects you from infection and all sorts of pathogens and cancers

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2
Q

Overreaction of the immune disease examples

A

Autoimmune diseases

Lethal allergies

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3
Q

What does the immune system do

A

Mounts elabatote rracrions against foreign material

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4
Q

Antigen

A

A substance that the immune system reacts against

Antigens are usually pieces of a pathogen, can be other things as well

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5
Q

WhT tools can be used to prevent infection

A

Limit access to tissues
Limit access to nutrients
Unfriendly environments (temp, PH)
Directly attack pathogen

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6
Q

Barriers - first line of defense

A

Skin (constant shedding)

Mucus/respiratory tract
Sneezing, coughing

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7
Q

Example of mechanical barriers

A

Tears, mucus,
Something that flushed away pathogens

Even bleeding, it washes away pathogens trying to get into wound

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8
Q

Chemical defenses

A

Lysozyme, stomach acid, antimicrobial proteins

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9
Q

Second line of defense characteristics

A

Consists of group of cells that respond to common features of pathogens

Chemical and cellular responses that are the same regardless of specific pathogen
Fever, inflammation are system responses by this line of defense

Patterns!!

Not highly specific

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10
Q

What cells carry out the second line of defense

A

White blood cells— come from bone marrow where they are produced

They are known as leukocytes collectively
All white blood cells are leukocytes

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11
Q

Lymphocytes

A

A specific type of leukocytes that generate antibodies

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12
Q

Neutrophils

A

A type of granulocuytes (white blood cell with granules)

Most common type of white blood cell,
Engulfs and kill bacteria; mediate inflammation

Example, puss filled area, it drowns the pathogen with puss

The nucleus is multi loved

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13
Q

Eosinophils

A

Fight parasites, participate in allergic responses
They are granulosytes

Multi lobed nucleus, red orange stain

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14
Q

Basophils

A

They are blue, fight parasites (attract a basic dye) participate in allergic reactions

The nucleus is obscured under a microscope, bi-lobed

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15
Q

Macrophages and dendritic cells

A

Yes phagocytosis: process of engulfing and destroying foreign mosteriaks mostly in the tissues not blood

Phagocytes: engulf bacteria mediate inflammation, present antigens to T cells

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16
Q

Monocytes

A

This is a macrophage in a different place

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17
Q

Lymphocytes

A

T cells, B cells, and NK cells
T and B can create memory immunity

They are small cells with large nuclei

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18
Q

Key process in second line of defense

A

Phagocytosis: when cells engulf and destroy cellular waste

Neutrophils, macrophages, dendritic cells

Recognize pathogens based on shared molecular patterns called pattern recognition receptors

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19
Q

Chemotaxis

A

Phagocyte moves toward pathogens by chemotaxis

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20
Q

Inflammation

A

Influx of blood to the area
Local cells secrete chemicals (cytokines) to drive the inflammatory process
Blood vessels dilate, bringing more blood
Cytokines make area painful to the touch

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21
Q

What inflammation accomplishes

A

Gets immune cells to the area first
Activates immune cells that are there
Elicits protective behaviors in host (pain, etc)

22
Q

2nd line of defense: fever

A

Can be induced by cytokines or pathogen associated molecules (pyrogens)

People believe fevers can be a good thing

23
Q

Fever can

A

Inhibit multiplication of viruses and fungi
Increase reactions and production of immune cells
Impede nuttier ion of bacteria by reducing iron availability

24
Q

2nd line of defense: antimicrobial protiens

A

Different chemicals with different tasks

25
Interferon protiens
Enhances immune cell growth Secreted by cells infected by a virus Accomplish three dif things: Signals nearby cells to stop producing protein If an interferon lands on a pathogen it will destroy itself Activates white blood cells
26
Compliment system
Second line of defense Stimulates phagocytes
27
Transferrens
Iron binding protiens Proteins that bind iron molecules to prevent pathogens from getting to them
28
Complement system
Composed of a series of protein cascades Inflammation Formation of the membrane attack complex Punches a hole in the cell membrane so the cytoplasm leaks leadining to the lysis and death of the invading cell
29
Cells involved in the third line of defense
B cells and T cells Called into action by the phagocytes and cytokines in the second line of defense
30
B cells
Make antibodies
31
Plasma cells
Mature B cells make antibodies much more quickly
32
Cytotoxic T cells
Interact directly with all the cells of the body
33
Hyper T Cells
Work with all the components to help them work
34
Antigen for third line of defense
A unique recognizable movie file that a lymphocyte recognizes is called an integer
35
Antigen presenting cells
Use their own receptor to show off their captured and destroyed bacterial prey
36
T and B cell effects
These cells make antibodies which interact with the pathogens Can be activated by interacting directly with pathogen but don’t directly fight the pathogens
37
MHC molecule
``` Individual cells hve their own MHC (class 1) If they are infected with a pathogen, foreign antigens might show up in the MHC class 1, if not, the resented peptides would all be self ``` Have an average cell Produce protiens Break those up Put them onto MHC class 1, and expose them to outside world If there is a virus then that’s also being presented because it’s also put onto MHC class 1 but usually it’s just broken down protien
38
MHC CLASS 2
Memory T and T effectors memory B and B effectors They live in the lymphatic tissue and Wsit there until we encounter the same pathogen B CELLS PRODUCE antibodies
39
T CELLS
Interact with antigen presented by an antigen presenting cell activates a B cell
40
T cell reactivity
T cells are educated during fetal and infant development The process which takes place in an organ called the thymus. This process removes T Cells that cannot recognize MHC molecules Are specific for and will react against self protiens Defects can lead to self reactive T cells that wage war on your own cells leads to autoimmune disease
41
T cells are selected based on what
Things can be foreign but not pathogenic ``` T cells have no way of telling the difference Like pollen (not pathogen but foreign to body so it reacts the same way as to a virus ```
42
Two different types of T cells
Cytotoxic Helper T cells- help everyone perform better by releasing cytokines rhat help other immune cells They activate B cells
43
B cell reactivity
Can interact directly with pathogen during activation | They need help from T cells
44
Opsimization
To make more susseptible to phagocytosis
45
IGG antibodies
Found in blood majority of antibodies made by plasma cells
46
IgM antibodies
First form created by B cells | Found in blood
47
IgA Antibodies
Found in mucus and breast milk, most common in whole body
48
Passive immunity
Babies at birth and breastfed babies recieve antibodies from mom resulting in passive immunity
49
Developing a strong immune system requires
Exposure to antigen/pathogens, overly sterile environments that contribute to allergies and asthma, important both to get sick to build immunity as well as to become immuno logically tolerant agents in our environment
50
The function of cortisol
It is a stress hormone, dampened the immune system Reduces production of cytokines, both in age and acquired immune response is compromised, promotes apoptosis of lymphocytes Cortisol can be used to suppress the immune system when necessary for example hydrocortisone poison ivy