Immune System Flashcards
(51 cards)
What is the complement system made of? What do they do?
Plasma proteins that lyse foreign cells
Where is MAC important in? What system?
Complement
What does MAC do?
Ruptures the bacterial membrane causing lysis of the bacteria and death
Functions of the complement system?
Destroy invading microbes by MAC, vasodilation and increased permeability, chemo taxis, opsonizarion
What is chemo taxis?
White blood cells go to an area of an infection
What does opsonization enhance?
Makes phagocytosis easier
What are the two primary lymphoid organs
Thymus and bone marrow
Where do T lymphocyte cells mature
Thymus
Where do you B lymphocyte cells mature
Bone marrow
How does the body know that it is infected?
Receptor binds to a ligand
What are the four receptors of inmate immunity
Toll like receptors, N formyl methionyl receptor, mannose receptor, scavenger receptor
What do toll like receptors do
They are PRR- pattern recognition receptors
What do N formyl methionyl receptors do
Mediate antimicrobial responses
What do you mannose receptors do
Initiate Phagocytosis of microbes
What do scavenger receptors do
Initiate phagocytosis is cellular debris
Sequence of events in a localized innate inflammatory response of bacteria
- Bacteria introduced so chemicals are released
- Vasodilation and increased capillary permeability
- Chemotaxis
- Distraction of bacteria
- Tissue repair
2 main functions of monocytes and macrophages
Phagocytosize & APC
When do T cells recognize antigens?
When they are associated with MHC molecules
Where class 1MHC molecules expressed
Surface of all nucleated cells
Where are class 2 MHC molecules expressed
Surface of macrophages, activated B cells, activated T cells and thymus cells
Who do NK cells target
Virus infected cells and cancer cells
Are NK cells antigen specific
No
How long does the primary immune response take
10 to 17 days after exposure
What happens in the primary immune response
Antigen selected B and T cells proliferate and differentiate into effector cells
