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usmle rx qbank > immuno > Flashcards

immuno Flashcards

(98 cards)

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1
Q

bouchard nodes

A

found on pip in OA

hard,bony outgrowths

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2
Q

RA finding in joints

A

bone cartilage erosion

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3
Q

origin of melanocytes

A

neural crest cells

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4
Q

notochord gives rise to

A

nucleus pulposus of the disc

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5
Q

mesoderm

A

connective tissue, muscle, bone, cartilage, cv organs, repro organs

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6
Q

endoderm

A

epithelial parts of GI tract, lungs, urethra

parenchyma of pancreas and liver

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7
Q

medullary cords conain

A

plasma cells and macrophages

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8
Q

paracortex

A

t cells …. absent in di george

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9
Q

extracellular pathogens are presented by wch MHC

A

MHC II invariant chain

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10
Q

3 alpha 1 beta globin chain

A

MHC 1 B2 globulin

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11
Q

cell surface molecule on all t cells

A

CD 3

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12
Q

CD 14

A

macrophages

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13
Q

CD 28

A

binds B7 onAPC

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14
Q

t cell receives first signal but no second signal what happens to this

A

anergy … known as peripheral tolerance

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15
Q

post gi infection child develops intusussception … why

A

peyer patches hyperplasia …. M cells present the antigen to B cells

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16
Q

job syndrome

A 
hyper igE …. inability of helper t cells to make interferon gamma
F coarse face 
Abscess
T retained primary Teeth
E igE
Derma eczema
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17
Q

antimicrosomal antibodies

A

hashimoto

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18
Q

pt has anemia, oral ulcers, photsensitivity rash but VDRL positive for syphilis too … whats the diag

A

SLE anti sm and an ds dna …. ths pt prbbly has antipohospholid antibodies that cross react with cardiolipin used in the vdrl test

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19
Q

pt has weakness and diplopia due to eyelids what tumor is assoc with this

A

thymoma

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20
Q

pts with sjogern syndrome are at high risk of wch cancer

A

non hodkin marginal b cell lymphoma

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21
Q

antimitochondrial antibodies are a hallmark for

A

PBC, autoimmune t cell atttackkkk on small intralobular bileducts

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22
Q

post streptococcal glomerulonephritis hypersensitivity type

A

type 3…. immune antibody complexes activate the complement

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23
Q

igA gomnephritis vs post strept

A

timeline … post strept after 3-6 weeks of infection with GAS

igA presents with nephritic syndrome concurrently with upper respt symptoms

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24
Q

lumpy bumpy subepithelial deposits

A

post strept

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25
mesangial deposits seen in
igA nephropathy
26
cant see cant pee cant bend my knee
reactive arthritis ….. salmonella shigella Yersinia camphylobacer
27
graft vs host disease is a type of which hypsenstvty
typ 4
28
hematopoetic stem cells have CD
CD34
29
erythema nodosum describe it
inflammation of subcutaneous fat …. in corhns disease,uc, tb, coccidomycosis, histoplasmosis
30
tnf alpha inhbitors what should u be careful with
check for tb …. can activate latent tb as tnf is used for granuloma formation in tb
31
pt receives foreign proteins … develops rash, fever and glmnephritis in 10 days why is this
serum sickness... type 3 ...induction of affinity matured b cell resp takes abt a week
32
endotoxin present on gram negative cell wall that leads to septic shock
LOS like in niseria menigitidis
33
recurrent pyogenic infections, inability to mount an igM response, eczema, thrombocytopenia
wiskot aldich ….
34
what is the site of self peptide loading on MHC1
rouigh endo (cytosolic or viral)
35
which common drug used in psych blocks the release of thyrpoid hormone
lithium
36
calcium pyrophosphate dihydrate deposition in CT | weakly birefiringent
pseudogout
37
nikolsky sign is seen in
pemphigus vulgaris … antidesmoglin
38
spike and dome apprnce
membranous glom
39
starry sky appearance on immunofluoresence
post strept glom
40
def of decay acc factor
PNH
41
young patient hemoptysis with concurrent hematuria.... worked in dry cleanin
gooooodpasture ...exposure to hydrocarbon solvent in cleaning dyes and cigarette
42
increased wbc count and >20% blast lymphoblastic cell
ALL mostly in children, they have neutropenia
43
birebeck granules are found in langerin cells which are APC in skin... these activate what type of cells?
T cells
44
treatment of brutons agammaglobulinemia
IV immunoglobulin
45
how is wiskott Aldrich different to brutons in terms of Ig
wiskot has increased igA and igE
46
if ccd4 count is less than 185 pt is at risk of whch bacteria
listeria (intracellular) | extracellular can be controlled by humoral resp
47
infection with helminths is monitored by
IgE that activates eosinophils
48
autoimmune hemolytic anemia txt
corticosteroids firt line
49
ascceding paralysis post diarrhea andfever
guillan barre ….. txt with immunoglobulins
50
abo incompatibility reaction type
HSTN typ 2 …. igM attack the rbc
51
HLA B 27 PAIR
psoriasis ankylosing spondylitis IBD Reactive arthritis
52
what cells are req to kill virally infected cells
NK cells
53
T cell markers
CD 3 CD28
54
B cell markers
CD 19 20 21
55
NK markers
CD 16 56
56
How are the numbers of b cells and nk cells in di George syndrome
normal
57
Kaposi sarcoma
hhv8 , malignant prolif of spindle cells and endothelial cells
58
GM CSF works on what precursor cell
myeloid stem cells
59
pt develops recurrent candida inf … no HIV … wat cell is resp for this
T cells …. rare codition called chronic mucocutaneous candidiasis
60
tetanus diptheria and hep c vaccine can cause wat immunological reaction
arthus type 3
61
which immunoglobulin opsonizes bacteria
igG
62
recurrent pneumonia, ear inf, fungal inf and candida suggest wat
HIV … check for CD4
63
CGD is diagnosed by what test
negative dehydrorhodamine test
64
daclizumab
high affinity for il2 receptors
65
sirolimus
binds to mtor protein and stops t cell prloif
66
binds to fk binding protein
tacrolimus
67
HLA DR5 what diseases are linked to this
hashimoto and pernicious anemia
68
what does IL 1 do
increase hypothalamic set point temperature …. fever
69
guillian barre mechanism
it is autoimmune
70
in penicillin induced hemolytic anemia penicillin acts as a...
hapten
71
what is a hapten
cannot illicit immune resp on its own.. needs to bind to a protein
72
GVHD what organs are mostly effected .. also symptoms are related to this
gut diarrhea skin rash liver elevated alp
73
kid with eczema, two rows of upper lower teeth and leathery skin with cold abscess, recurrent staph inf
job synd …. hyper igE ….th17 fail to produce il 17... leads to inability of neutrophils to respond top stimuli
74
acute phase interleukin
il6 … 1, 8 TNF alpha
75
immigrant from central America … childhood asthma and atopic dermatitis... presents with loss of eyebrows and eyelashes … diminished pinprick and light touch what disease is this and what interleukin is imp for this pt
leprosy …. th1 mediated so interferon gama is imp
76
lambert eaton …. mechanism
presynaptic ca channels ….. overstimiulation helps elicit a respoinse
77
abnormally large platelet can be seen in
ITP … because body tries to make more platelets
78
ITP mechanism
antibodies to gp11b IIIa .... low platelets, large platelet size
79
low igM and increased igA and G
wiskot aldrich
80
live attenuated vaccines illicit wat response
humoral and cell mediated
81
examples of live vaccines Music and lYRICSS
MMR, yellow fever, Rubella, Influenza (intranasal), chickenpox VZV, smallpox, sabin polio
82
inactive or killed vaccines
only humoral response
83
examples of killed vaccines
RIP Always | Rabies, Influenza (injection), polio salk and HAV vaccines
84
one spike of fever in a day … in children.... high wbc count … arthralgia … rash on body
systemic juvenile idiopathic arthritis
85
granulomatosis with polyangiitis
cANCA, lungs liver and nasopharyngeal symptoms
86
follicles in lymph node
site for b cell maturation, pale centers are active
87
how will b lymphocyte deficiency show up on LN histo
no follicles in cortex ,,,, treat with gamma globin injection
88
pt with hodkin what type of graft
autogenic … no need for immunosuppression... least likely to be rejected
89
diptheria vaccine type
toxoid ….
90
pt has spider angioma and low igA what is the conditon
ataxia telangectasia …. triad of ataxia, immune def and spider angioma
91
ataxia telengectasia mechanism
ATM gene defect... failure to repair double stranded breaks
92
igm in free circulation can bind how many antigens
10
93
kid has migratory polyarthritis and nodes in elbow
rheumatic fever /… auntoimmune
94
azathioprine maine SE
bone marrow suppression
95
dacalizumab mechanism
monoclonal ab that binds IL2 receptors
96
reed sterberg cells mostly positive for
CD 15 and CD 30
97
borrelia burdorferi is a ...
spirochete cork screw shape
98
def of metaloproteiase
TTP …. this breaks down large vWF muitimers

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