resp onc 6

Question 1

MEN 1

Answer 1

parathyroid
pituitary
pancreas (insulinoma, Zollinger etc)

Question 2

MEN 2A

Answer 2

medullary thyroid
pheo
parathyroid

Question 3

mechanism of rifampin

Answer 3

inhibits dna dep merase to stop DNA synt

Question 4

inhibits arabinosyl transferase

Answer 4

ethambutol

Question 5

pyrazinamaide

Answer 5

inhibits FA synthase 1

Question 6

how to treat hemorrhagic cystitis by cyclophosphamide

Answer 6

mesna ( binds toxic metabolites)

Question 7

what is dexrazoxane used for

Answer 7

iron chelator … avoid toxicity by doxorubicin

Question 8

risk factors for nasopharyngeal carcinoma

Answer 8

Asian, male, high salt meat and fish diet …

EBV hhv4

Question 9

HIV pt … stopped HAART and has rash on face arms and legs

reddish purple raised nodules … what are these

Answer 9

kaposi sarcoma HHv8 … AIDs defining illness

Question 10

Kaposi sarcoma most like other assoc

Answer 10

black stools

Question 11

cyanide mechanism of action

Answer 11

binds cytochrome oxidase … stops electron transport chain…. cellular resp halter

Question 12

antidote for cyanide poisoning and its mechanism

Answer 12

hydroxycobalamin … binds cyanide directly
methemoglobinemia… with nitrite
thiosulfate

Question 13

history of contruction work, dyspnea, pleural thickening

Answer 13

mesothelioma
assoc with asbestosis … only pneumoconiosis with upper lobe affected
yellow brown shape bodies with clubbed ends and stain with Prussian blue

Question 14

heart failure pt wat can be seen in alveoli (histo)

Answer 14

hemosiderin laden macrophages

Question 15

occupation that involves asbestos exposuire

Answer 15

shipyard, plumbing and insulation installation

Question 16

leuprolide mechanism

Answer 16

GnRH inhibition ….. low LH FSH levels

Question 17

GHRH antaginst name

Answer 17

somatostatin

Question 18

deadly cancer men

Answer 18

lung prostate and colorectal

Question 19

deadly cancer women

Answer 19

lung breast colon

Question 20

most common cancer men

Answer 20

prostate lung and colon

Question 21

most common cancer women

Answer 21

breast lung colon

Question 22

woman breast cancer metastasis and surgery presents with tachycardia tachypnea and pleuritic chest pain

Answer 22

PE …. cancer can increase risk of coagulation

Question 23

mucus plugs form in assoc with which genetic condition

Answer 23

CF chromosome 7 phe508 protein misfolding

Question 24

why is sarcoidosis assoc with increase calcium

Answer 24

activats 1 alpha hydroxylase within the macrophages that makes active vit D form \
ant uveitis, polyarthritis, lymphadenopathy

Question 25

productive cough, abd pain, diarrhea and hyponatremia

Answer 25

charcoal extract yeast agar …. legionella

Question 26

can legionella cause TTP

Answer 26

yes ...anticodies crossreact with ADAM TS13 an enzyme that degrades vWF ...

Question 27

5FU, methotrexate and 6mercaptopurin

Answer 27

S phase

Question 28

bleomycin

Answer 28

g2 phase

Question 29

Thayer martin

Answer 29

N gonorrhea

Question 30

bilateral symmetrical peribronchiovascular alveolar processes in a transplant patient …. what infection??

Answer 30

CMV env linear DsDNA | LATENT in mononuclear cells

Question 31

non env linear DsDNA

Answer 31

adeno

Question 32

how to terminate pregnancy and treat choriocarcinoma a trophoblastic disease

Answer 32

methotrexate … s phase ….

Question 33

what causes an increase in 2BPG

Answer 33

compensatory mechanism of high altitude for ex

Question 34

pt with leogeneires disease risk factors

Answer 34

``` older pts smoking alcohol diabetes cronic illness ```

Question 35

silicosis vs desquamative interstitial pneumonia

Answer 35

History very imp … check for work places silicosis usually work in foundries, sandblasting, glass etc

Question 36

what kind of necrosis can be seen in aspiration pneumonia

Answer 36

liquefactive necrosis

Question 37

RB gene function

Answer 37

binds to E2F that stops progression from G1 to S

Question 38

stop cell progression from G2 to M

Answer 38

CHK1 CHK2 kinases

Question 39

what is the process called when a virus 'borrows' functional protein from another to become active for ex hep D

Answer 39

complementation

Question 40

what causes influenza pandemics

Answer 40

reassortment genetic shif t

Question 41

which cancer in the lungs is assoc with PTHrp

Answer 41

squamous cell … central

Question 42

post operative... diaphragm high and incrase lucency

Answer 42

atelectasis | common complication post surgery

Question 43

how does tamoxifen inhibit bone loss

Answer 43

inhibits osteoclasts

Question 44

hyperstimulation of ovaries can be seen with whch drug

Answer 44

clomiphene

Question 45

African American woman … ACE elevated what is the diagnosis

Answer 45

sarcoidosis

Question 46

pt has sarcoidosis … gets her treatment and then presents with certain symptoms due to overdose

Answer 46

cushing … due to treatment with steroids

Question 47

mechanism of acetazolamide

Answer 47

decrease H+ secretion in proximal tubule

Question 48

strept pneumo vaccine before 65

Answer 48

pneumococcal polysaccharide vaccine | ppsv23

Question 49

PPSV23 immune resp

Answer 49

not comjugated to protein so cannot be presented to T cells on MHC 2

Question 50

enveloped +ve sense ss RNA virus

Answer 50

coronavirus common cold

Question 51

non enveloped +ve sense ss RNA virus

Answer 51

``` picornavirdae P polio E echovirus aseptic meningtis R rhino C coxsackie H HAV ```

Question 52

what are the most common chemo agents for wilms tumor

Answer 52

vincristine ( B tubulin prevent spindle formation) bleomycin ( induce free radicles and cause DNA breakage) dactinomycin ( intercalates into DNA prevent RNA synth)