Immuno memorize Flashcards
(81 cards)
1
Q
Anti-ACh receptor
A
Myasthenia gravis
2
Q
Anti-basement membrane
A
Goodpasture syndrome
3
Q
Anti-cardiolipin, lupus anticoagulant
A
SLE, antiphospholipid syndrome
4
Q
Anticentromere
A
Limited scleroderma (CREST syndrome)
5
Q
Anti-dsDNA, anti-Smith
A
SLE
6
Q
Anti-glutamate decarboxylase
A
Type 1 diabetes mellitus
7
Q
Anti-hemidesmosome
A
Bullous pemphigoid
8
Q
Antihistone
A
Drug-induced lupus
9
Q
Anti-Jo-1, anti-SRP, anti-Mi-2
A
Polymyositis, dermatomyositis
10
Q
Antimicrosomal, antithyroglobulin
A
Hashimoto thyroiditis
11
Q
Antimitochondrial
A
1° biliary cirrhosis
12
Q
Antinuclear antibodies
A
SLE, nonspecific
13
Q
Anti-Scl-70 (anti-DNA topoisomerase I)
A
Scleroderma (diffuse)
14
Q
Anti-smooth muscle
A
Autoimmune hepatitis
15
Q
Anti-SSA, anti-SSB (anti-Ro, anti-La)
A
Sjögren syndrome
16
Q
Anti-TSH receptor
A
Graves disease
17
Q
Anti-U1 RNP (ribonucleoprotein)
A
Mixed connective tissue disease
18
Q
c-ANCA (PR3-ANCA)
A
Granulomatosis with polyangiitis (Wegener)
19
Q
IgA antiendomysial, IgA anti-tissue transglutaminase
A
Celiac disease
20
Q
p-ANCA (MPO-ANCA)
A
Microscopic polyangiitis, Churg-Strauss syndrome
21
Q
Rheumatoid factor (antibody, most commonly IgM, specific to IgG Fc region), anti-CCP
A
Rheumatoid arthritis
22
Q
Anti-desmoglein
A
Pemphigus vulgaris
23
Q
IL-1:
A
fever (hot).
24
Q
IL-2:
A
stimulates T cells.
25
IL-3:
stimulates bone marrow.
26
IL-4:
stimulates IgE production.
27
IL-5:
stimulates IgA production.
28
IL-6:
stimulates acute-phase protein
| production.
29
Splenic dysfunction has susceptibility to which encapsulated organisms?
```
(SHiNE SKiS):
Streptococcus pneumoniae
Haemophilus influenzae type B
Neisseria meningitidis
Escherichia coli
Salmonella spp.
Klebsiella pneumoniae
Group B Streptococci
```
30
What type of cells may be present postsplenectomy?
Howell-Jolly bodies (nuclear remnants)
Target cells
Thrombocytosis
31
HLA-A3
Hemochromatosis
32
HLA-B27
```
PAIR => seronegative arthropathies
Psoriatic arthritis
Ankylosing spondylitis
Inflam bowel dz arthriitis
Reactive arthritis (Reiter syndrome)
```
33
HLA-DQ2/DQ8
Celiac dz
34
HLA-DR2
MS, hay fever, SLE, Goodpasture syndrome
35
HLA-DR3
DM type I, SLE, Graves
36
HLA-DR4
Rheumatoid arthritis, DM type I
37
HLA-DR5
Pernicious anemia due to vit B12 deficiency;
| Hashimoto thyroiditis
38
What does Th-1 secrete? activate? what inhibits it?
Secretes IFN-y
Activates macs & CD8 (CTLs)
Inhibited by IL-4, IL-10 (from Th-2 cell)
39
What does Th-2 secrete? activate? what inhibits it?
Secretes IL-4, 5, 6, 13
Recruits eosinophils for parasite defense & promotes IgE production by B cells
Inhibited by IFN-y (from Th-1 cell)
40
Define acute phase reactants
factors whose serum [ ] change significantly in response to inflammation => produced by liver in both acute & chronic inflammatory states
41
What induces production of acute phase reactants?
IL-6, IL-1, TNF-alpha, IFN-y
42
What acute phase reactants are upregulated in inflammatory states? what is the result?
Serum Amyloid A => prolonged elevation leads to amyloidosis
CRP => opsonin; fixes complement & facilitates phagocytosis & measure of ongoing inflammation
Ferritin => binds & sequesters Fe++ to inhibit microbial Fe+ scavenging
Fibrinogen => Coag factor; promotes endothelial repair; correlates w/ ESR
Hepcidin => prevents release of Fe+ bound by ferritin indicating anemia of chronic dz
43
What acute phase reactants are downregulated in inflammatory states? what is the purpose?
Albumin => reduction conserves AA for positive reactants
Transferrin => internalized by macrophages to sequester iron
44
C3 deficiency has what affects?
Increases risk of severe, recurrent pyogenic sinus and respiratory tract infections;
increases susceptibility to type III hypersensitivity reactions.
45
What is contraindicated in C1 esterase inhibitor deficiency?
ACE inhibitors
46
What is the result of DAF (GPI anchored enzyme) deficiency?
Causes complement-mediated lysis of RBCs & paroxysmal nocturnal hemoglobinuria.
47
Presentation of type I HSR
immediate, anaphylactic, atopic
48
Presentation of type II HSR
Dz tends to be specific to tissue or site where antigen is found
49
Presentation of type III HSR
can be assoc w/ vasculitis & systemic manifestations
50
presentation of type IV HSR
response is delayed & does NOT involve Abs
51
Presentation of bacterial infection w/ no T cells
Sepsis
52
Presentation of bacterial infection w/ no B cells
Encapsulated => (SHiNE SKiS)
Streptococcus pneumoniae, Haemophilus influenzae type B, Neisseria meningitidis, Escherichia coli, Salmonella, Klebsiella pneumoniae, group B Strep
53
Presentation of bacterial infection w/ no granulocytes
Staphylococcus, Burkholderia cepacia, Serratia, Nocardia
54
Presentation of bacterial infection w/ no complement
Neisseria (no membrane attack complex)
55
Presentation of viral infection w/ no T cells
CMV, EBV, JCV, VZV chronic infection with respiratory/GI viruses
56
Presentation of viral infection w/ no B cells
Enteroviral encephalitis, poliovirus
| live vaccine contraindicated
57
Presentation of viral infection w/ no granulocyte or complement
nothing special
58
Presentation of fungi/parasites infection w/ no T cells
Candida, PCP
59
Presentation of fungal/parasites infection w/ no B cells
GI giardiasis (no IgA)
60
Presentation of fungi/parasites infection w/ no granulocyte
Candida, Aspergillus
61
Epoetin alfa (erythropoietin)
Anemias (especially in renal failure)
62
Thrombopoietin
Thrombocytopenia
63
Oprelvekin (interleukin-11)
Thrombocytopenia
64
Filgrastim (granulocyte colony-stimulating factor)
Recovery of bone marrow
65
Sargramostim (granulocyte-macrophage colony- stimulating factor)
Recovery of bone marrow
66
Aldesleukin (interleukin-2)
Renal cell carcinoma, metastatic melanoma
67
IFN-α
Chronic hepatitis B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma
68
IFN-β
Multiple sclerosis
69
IFN-γ
Chronic granulomatous disease
70
Therapeutic Ab for use in CLL . What is the Target?
Alemtuzumab
| CD52
71
Therapeutic Ab for use in Colorectal cancer, renal cell carcinoma. What is the Target?
Bevacizumab
| VEGF
72
Therapeutic Ab for use in Stage IV colorectal cancer, head and neck cancer. What is the Target?
Cetuximab
| EGFR
73
Therapeutic Ab for use in B-cell non-Hodgkin lymphoma, rheumatoid arthritis (with MTX), ITP. What is the Target?
Rituximab
| CD20
74
Therapeutic Ab for use in Breast cancer, gastric cancer. What is the Target?
Trastuzumab
| HER2/neu
75
Therapeutic Ab for use in IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis. What is the Target?
Infliximab, adalimumab
| TNF-α
76
Therapeutic Ab for use in Multiple sclerosis, Crohn disease. What is the Target?
Natalizumab
| α4-integrin
77
Therapeutic Ab for use in Anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention. What is the Target?
Abciximab
| Glycoprotein IIb/IIIa
78
Therapeutic Ab for use in Osteoporosis; inhibits osteoclast maturation (mimics osteoprotegrin). What is the Target?
Denosumab
| RANKL
79
Therapeutic Ab for use in Antidote for digoxin toxicity. What is the Target?
Digoxin immune Fab
| Digoxin
80
Therapeutic Ab for use in Allergic asthma; prevents IgE binding to FcεRI. What is the Target?
Omalizumab
| IgE
81
Therapeutic Ab for use in RSV prophylaxis for high-risk infants. What is the Target?
Palivizumab
| RSV F protein
