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Flashcards in Biochem Deck (32)
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1

Lab findings/screen of down syndrome before birth

quad screen: decreased AFP & estriol; increased Beta-hCG & inhibin A
increased nuchal in 1st trimester translucency on ultrasound

2

Lab findings/ screen of trisomy 18 (Edwards) before birth

quad screen: decreased AFP, Beta-hCG, estriol; normal inhibin A

3

Lab findings/ screen of trisomy 13 (Patau's) before birth

decreased free Beta-hCG, PAPP-A
increased nuchal translucency

4

increased RBC fragility

vit E deficiency

5

Dermatitis, cheoliosis, glossitis

B2 deficiency

6

Peripheral neuropathy, glossitis

B12 deficiency

7

hemorrhagic dz

Vitamin K deficiency

8

dermatitis, diarrhea, dementia

Vit B3 deficiency

9

Megaloblastic anemia

Vit B12 or Folate deficiency

10

pernicious anemia

Vit B12 deficiency

11

Bitot spots, keratomalalcia, xerophthalmia

Vit A deficiency

12

Osteomalacia & Rickets

vit D deficiency

13

Acne & psoriasis association

vit A

14

oxidation / reduction rxn association

vit B2 & B3

15

carboxylation rxn association

Biotin (vit B7)

16

hydroxylation of propyl residue association

vit C

17

Requires IF for absorption

vit B12

18

deficiency in kidney disease

vit D

19

vitamins used in pyruvate DH & alpha-KG DH

vit B1, B2, B3, B5, lipoic acid

20

vitamin given prophylactically to newborn

vit K

21

vitamin used to elevate HDL & lower LDL

niacin (vit B3)

22

deficiency caused by INH use

vit B6

23

Cobalt w/in vitamin structure

vit B12

24

vitamin critical for DNA synthesis

folate & B12

25

Metabolism in the mitochondria

FA oxidation (Beta-oxidation); acetyl-CoA production; TCA cycle; oxidative phosphorylation

26

Metabolism in the cytoplasm

Glycolysis; FA synthesis; HMP shunt; protein synthesis (RER); Steroid synthesis (SER); cholesterol synthesis

27

Metabolism in both mitochondria & cytoplasm

Heme synthesis; Urea cycle; Gluconeogenesis

28

Define kinase

uses ATP to add high energy phosphate group onto substrate (phosphofructokinase)

29

Define phosphorylase

adds inorganic phosphate onto substrate w/o using ATP (glycogen phosphorylase)

30

Define phosphatase

Removes phosphate group from substrate (fructose-1,6-bisphosphatase)