Pharm general Flashcards
(108 cards)
1
Q
Acetaminophen o/d
A
N-acetylcysteine (replenishes glutathione)
2
Q
AChE inhibitors, organophosphates o/d
A
Atropine followed by pralidoxime
3
Q
Amphetamines (basic) o/d
A
NH4Cl (acidify urine)
4
Q
Antimuscarinic, anticholinergic agents o/d
A
Physostigmine salicylate, control hyperthermia
5
Q
Benzodiazepines o/d
A
Flumazenil
6
Q
β-blockers o/d
A
Glucagon
7
Q
Carbon monoxide o/d
A
100% O2, hyperbaric O2
8
Q
Copper, arsenic, gold o/d
A
Penicillamine
9
Q
Cyanide o/d
A
Nitrite + thiosulfate, hydroxocobalamin
10
Q
Digitalis o/d
A
Anti-dig Fab fragments
11
Q
Heparin o/d
A
Protamine sulfate
12
Q
Iron o/d
A
Deferoxamine, deferasirox
13
Q
Lead o/d
A
EDTA, dimercaprol, succimer, penicillamine
14
Q
Mercury, arsenic, gold o/d
A
Dimercaprol (BAL), succimer
15
Q
Methanol, ethylene glycol (antifreeze) o/d
A
Fomepizole > ethanol, dialysis
16
Q
Methemoglobin o/d
A
Methylene blue, vitamin C
17
Q
Opioids o/d
A
Naloxone
18
Q
Salicylates o/d
A
NaHCO3 (alkalinize urine), dialysis
19
Q
TCAs o/d
A
NaHCO3 (plasma alkalinization)
20
Q
tPA, streptokinase, urokinase o/d
A
Aminocaproic acid
21
Q
Warfarin o/d
A
Vitamin K, plasma (if active bleeding)
22
Q
What Rx causes Coronary vasospasm
A
Cocaine, sumatriptan, ergot alkaloids
23
Q
What Rx causes Cutaneous flushing
A
Vancomycin, Adenosine, Niacin, Ca2+ channel blockers
24
Q
What Rx causes Dilated cardiomyopathy
A
Doxorubicin, daunorubicin
25
What Rx cause Torsades de pointes
Class III (e.g., sotalol) and class IA (e.g., quinidine) antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs
26
What Rx cause Adrenocortical insufficiency
HPA suppression 2° to glucocorticoid withdrawal
27
What Rx cause Hot flashes
Tamoxifen, clomiphene
28
What Rx cause Hyperglycemia
Tacrolimus, Protease inhibitors, Niacin, HCTZ,
| β-blockers, Corticosteroids
29
What Rx cause Hypothyroidism
Lithium, amiodarone, sulfonamides
30
What Rx cause Acute cholestatic hepatitis, jaundice
Erythromycin
31
What Rx cause Diarrhea
Metformin, Erythromycin, Colchicine, Orlistat, Acarbose
| Might Excite Colon On Accident
32
What Rx cause Focal to massive hepatic necrosis
Halothan, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen
Liver "HAVAc"
33
What Rx cause Hepatitis
INH
34
What Rx cause Pancreatitis
Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)
35
What Rx cause Pseudomembranous colitis
Clindamycin, ampicillin, cephalosporins
36
What Rx cause Agranulocytosis
Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil
Drugs CCCrush Myeloblasts and Promyelocytes
37
What Rx cause Aplastic anemia
Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil
Can’t Make New Blood Cells Properly
38
What Rx cause Direct Coombs- positive hemolytic anemia
Methyldopa, penicillin
39
What Rx cause Gray baby syndrome
Chloramphenicol
40
What Rx cause Hemolysis in G6PD deficiency
INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
hemolysis IS D PAIN
41
What Rx cause Megaloblastic anemia
Phenytoin, Methotrexate, Sulfa drugs
having a "blast" w/ PMS
42
What Rx cause Thrombocytopenia
Heparin, cimetidine
43
What Rx cause Thrombotic complications
OCPs (e.g., estrogens)
44
What Rx cause Fat redistribution
Protease inhibitors, Glucocorticoids
Fat PiG
45
What Rx cause Gingival hyperplasia
Phenytoin, verapamil, cyclosporine, nifedipine
46
What Rx cause Hyperuricemia (gout)
Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
Painful Tophi and Feet Need Care
47
What Rx cause Myopathy
Fibrates, niacin, colchicine, hydroxychloroquine, interferon-α, penicillamine, statins, glucocorticoids
48
What Rx cause Osteoporosis
Corticosteroids, heparin
49
What Rx cause Photosensitivity
Sulfonamides, Amiodarone, Tetracyclines, 5-FU
SAT For Photo
50
What Rx cause Rash (Stevens- Johnson syndrome)
Anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, Sulfa drugs, Penicillin
Steven Johnson has epileptic Allergy to Sulfa
drugs and Penicillin
51
What Rx cause SLE-like syndrome
Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept
having lupus is "SHIPP-E"
52
What Rx cause Teeth discoloration
Tetracyclines
53
What Rx cause Tendonitis, tendon rupture, and cartilage damage
Fluoroquinolones
54
What Rx cause Cinchonism
Quinidine, quinine
55
What Rx cause Parkinson-like syndrome
Antipsychotics, Reserpine, Metoclopramide
56
What Rx cause Seizures
INH (vitamin B6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
57
What Rx cause Tardive dyskinesia
Antipsychotics, metoclopramide
58
What Rx cause Diabetes insipidus
Lithium, demeclocycline
59
What Rx cause Fanconi syndrome
Expired tetracycline
60
What Rx cause Hemorrhagic cystitis
Cyclophosphamide, ifosfamide
61
What Rx cause Interstitial nephritis
Methicillin, NSAIDs, furosemide
62
What Rx cause SIADH
Carbamazepine, Cyclophosphamide, SSRIs
63
What Rx cause Dry cough
ACE inhibitors
64
What Rx cause Pulmonary fibrosis
Bleomycin, Amiodarone, Busulfan, Methotrexate
Breathing Air Badly from Medications
65
What Rx cause Antimuscarinic
Atropine, TCAs, H1-blockers, antipsychotics
66
What Rx cause Disulfiram-like reaction
Metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st-generation sulfonylureas

67
What Rx causes Nephrotoxicity/ ototoxicity
Aminoglycosides, vancomycin, loop diuretics, cisplatin
68
What are the inducers of CYP450?
```
Chronic alcohol use
Modafinil
St. John’s wort
Phenytoin
Phenobarbital
Nevirapine
Rifampin
Griseofulvin
Carbamazepine
```
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs
69
What are substrates of CYP450?
```
Anti-epileptics
Antidepressants
Antipsychotics
Anesthetics
Theophylline
Warfarin
Statins
OCPs
```
Always, Always, Always, Always Think When Starting Others
70
What are the inhibitors of CYP450?
```
Acute alcohol abuse
Gemfibrozil
Ciprofloxacin
Isoniazid
Grapefruit juice
Quinidine
Amiodarone
Ketoconazole
Macrolides
Sulfonamides
Cimetidine
Ritonavir
```
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls
71
Name the sulfa drugs
```
Probenecid,
Furosemide,
Acetazolamide,
Celecoxib,
Thiazides,
Sulfonamide antibiotics,
Sulfasalazine,
Sulfonylureas.
```
Popular FACTSSS
72
-azole
Ergosterol synthesis inhibitor
73
-bendazole
Antiparasitic/antihelmintic
74
-cillin
Peptidoglycan synthesis inhibitor
75
-cycline
Protein synthesis inhibitor
76
-ivir
Neuraminidase inhibitor
77
-navir
Protease inhibitor
78
-ovir
DNA polymerase inhibitor
79
-thromycin
Macrolide antibiotic
80
-ane
Inhalational general anesthetic
81
-azine
Typical antipsychotic
82
-barbital
Barbiturate
83
-caine
Local anesthetic
84
-etine
SSRI
85
-ipramine
TCA
86
-triptan
5-HT1B/1D agonists
87
-triptyline
TCA
88
-zepam
Benzodiazepine
89
-zolam
Benzodiazepine
90
-chol
Cholinergic agonist
91
-curium or -curonium
Non-depolarizing paralytic
92
-olol
β-blocker
93
-stigmine
AChE inhibitor
94
-terol
β2-agonist
95
-zosin
α1-antagonist
96
-afil
PDE-5 inhibitor
97
-dipine
Dihydropyridine CCB
98
-pril
ACE inhibitor
99
-sartan
Angiotensin-II receptor blocker
100
-statin
HMG-CoA reductase inhibitor
101
-dronate
Bisphosphonate
102
-glitazone
PPAR-γ activator
103
-prazole
Proton pump inhibitor
104
-prost
Prostaglandin analog
105
-tidine
H2-antagonist
106
-tropin
Pituitary hormone
107
-ximab
Chimeric monoclonal Ab
108
-zumab
Humanized monoclonal Ab
