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Flashcards in Rate determining enzymes of metabolic processes Deck (13)
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1

Name enzyme & regulators for glycolysis

Enzyme: Phosphofructokinase-1 (PFK-1)
(+) Regulators: AMP
(-) Regulators: fructose-2,6-bisphosphate, ATP, citrate

2

Name enzyme & regulators for gluconeogenesis

Enzyme: Fructose-1,6-Bisphosphatase
(+)Regulators: ATP; acetyl-CoA
(-)Regulators: AMP, F-2,6-Bisphos

3

Name enzyme & regulators for TCA cycle

Enzyme: isocitrate DH
(+)Regulators: ADP
(-)Regulators: ATP, NADH

4

Name enzyme & regulators for Glycogenesis

Enzyme: Glycogen synthase
(+)Regulators: G-6-P, insulin, cortisol
(-)Regulators: Epi, glucagon

5

Name enzyme & regulators for Glycogenolysis

Enzyme: Glycogen phosphorylase
(+)Regulators: Epi, glucagon, AMP
(-)Regulators: G-6-P, insulin, ATP

6

Name enzyme & regulators for HMP shunt

Enzyme: G6PD
(+)Regulators: NADP+
(-)Regulators: NADPH

7

Name enzyme & regulators for de novo pyrimidine synthesis

Enzyme: Carbamoyl phosphate synthetase 2
(+)Regulators: none
(-)Regulators: none

8

Name enzyme & regulators for de novo purine synthesis

Enzyme: glutamine PRPP amidotransferase
(+)Regulators: none
(-)Regulators: AMP, IMP, GMP

9

Name enzyme & regulators for urea cycle

Enzyme: Carbamoyl phosphate synthetase 1
(+)Regulators: N-acetylglutamate
(-)Regulators:

10

Name enzyme & regulators for FA synthesis

Enzyme: Acetyl-CoA carboxylase (ACC)
(+)Regulators: insulin, citrate
(-)Regulators: glucagon, palmitoyl-CoA

11

Name enzyme & regulators for FA oxidation

Enzyme: Carnitine acyltransferase 1
(+)Regulators:
(-)Regulators: Malonyl-CoA

12

Name enzyme & regulators for Ketogenesis

Enzyme: HMG-CoA synthase
(+)Regulators: none
(-)Regulators: none

13

Name enzyme & regulators for cholesterol synthesis

Enzyme: HMG-CoA reductase
(+)Regulators: insulin, thyroxine
(-)Regulators: glucagon, cholesterol