Immunology Peer Tute 3 Flashcards
(28 cards)
What are the components of humoral immunity?
B cells
Abs
Humoral vs cellular immunity: which can undergo affinity maturation?
Humoral
Humoral vs cellular immunity: which can target intracellular antigens?
Cellular
Define epitope
The site on an antigen where the BCR/TCR binds
What are the two chains of an antibody?
Light chain
Heavy chain
What are the two domains of an antibody?
Fab (antigen-binding)
Fc (constant)
Which chains is the Fab region made of?
Heavy & light
Which chains is the Fc region made of?
Heavy only
Which domain determines isotype?
Fc
Which two isotypes are expressed on naive B cells?
IgM
IgG
Which isotype is the least common?
IgD
“IgDud”
Which isotype is the most abundant in plasma?
IgG
Which isotype provides transplacental immunity?
IgG
Which isotype structure maximises avidity?
IgM, as it has 5 binding sites
Which isotype is found mostly pre-bound to its cognate receptor?
IgE
Which isotype is important in type 1 hypersensitivities?
IgE
Which isotype is important in parasite immunity?
IgE
Which isotype provides mucosal immunity?
IgA
Which Abs exist as a monomer?
IgG
IgE
IgA (sometimes)
Which Abs exist as a dimer?
IgA
Which Abs exist as a pentamer?
IgM
What are some opsonins?
IgG
C3b
C5b
(‘b” for binding component)
How does Ab-dependent cellular cytotoxicity work?
When the cell that an IgG has bound to is too large to be engulfed, the NK cells which have corresponding FcyR are recruited. They release perforin and granzymes to kill the cell.
What’s the name of the receptor for IgG’s Fc region?
FcyR
Fc”gamma” receptor
