W2/L5

Question 1

List 3 places we commonly measure temperature

Answer 1

Sublingual
Ear canal
Rectal

Question 2

What’s normal temperature?

Answer 2

36-37.5 C

Question 3

At what time in the day does temperature tend to be higher? And by how much?

Answer 3

.6’ higher in the evening

Question 4

Other than diurnal temperature variation, what’s another type of periodic temperature change? By how much?

Answer 4

Menstrual - 1’ higher post-ovulation

Question 5

What do we call the molecule that triggers a fever?

Answer 5

Pyrogen

Question 6

What do pyrogens do? What’s the result?

Answer 6

Causes PGE2 release which acts on the hypothalamus to raise set point.

Question 7

List the major endogenous pyrogens (2)

Answer 7

IL-1

IL-6

Question 8

What’s the main exogenous pyrogen?

Answer 8

LPS

Question 9

How to exogenous pyrogens act?

Answer 9

By causing release of endogenous pyrogens

Question 10

What are the broad responses to raised temperature set point?

Answer 10

Heat generation

Heat conservation