Immunology Peer Tute 6 Flashcards
1
Q
What does TLR-4 bind?
A
LPS
2
Q
What does LFA-1 bind?
A
ICAM-1
3
Q
What does VLA-4 bind?
A
VCAM-1
4
Q
What does Sialyl-Lewis X bind?
A
E-selectin
5
Q
What does CXCLR8 bind?
A
CXCL8
6
Q
What is the action of CXCL8?
A
It’s a chemoattractant for PMNs
7
Q
What is the outcome of CXCL8-CXCL8R binding?
A
Conformational change in LFA-1, which allows it to bing ICAM-1 with high affinity and stick to the endothelium
8
Q
Which chemokines are responsible for activation of vascular endothelium?
A
TNF-alpha
IL-1
9
Q
What happens in activated endothelium?
A
Upregulation of adhesion molecules
