Immunology Peer Tute 5

Question 1

Which is the cytokine drives Th1 differentiation

Answer 1

IL-12

IGN-gamma

Question 2

What cytokines are secreted by Th1 cells?

Answer 2

IL-2
IFN-gamma
LT (lymphotoxin)

Question 3

What does IL-2 do?

Answer 3

T-cell growth

Question 4

What does IFN-gamma do?

Answer 4

Activate macrophages
Increase expression of HLAs
Induces an antiviral state
NK activation

Question 5

What does LT do?

Answer 5

Activates macrophages and PMNs

Induces NO production

Question 6

For which pathogens is Th1 important?

Answer 6

Extracellular microbes

Microbes that persist in macrophages (Mycobacteria, listeria, Pneumocystic Jirovecii)

Question 7

Which diseases are Th1-driven?

Answer 7

MS
Type 4 hypersensitivity
Diabetes mellitus

Question 8

Which cytokine drives Th2 differentiation?

Answer 8

IL-4

Question 9

What cytokines are produces by Th2 cells?

Answer 9

IL-4
IL-5
IL-13

Question 10

What does IL-4 do?

Answer 10

Induces B cells to switch to IgE

Question 11

What does IL-5 do?

Answer 11

Activates eosinophils

Question 12

For which pathogens is Th2 important?

Answer 12

Parasites (eg Helminths)

Question 13

Which diseases are Th2-driven?

Answer 13

Type 1 hypersensitivity

Anaphylaxis

Question 14

What are the 3 signals for B cell activation?

Answer 14

• Cross linking of BCR by Ag
• B cell CD40 ligated by T cell CD40L
• Cytokines from the T cell

Question 15

What happens after the BCRs bind the antigen?

Answer 15

It’s internalised and presented on MHC

Question 16

What’s the enzyme required for somatic hypermutation?

Answer 16

Activation-induced cytadine deaminase

AID