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Flashcards in immunoped Deck (49):
1

organ that develops and maintains peripheral lymphoid tissues

thymus

2

2 major functions of thymus

maturation of precursor T-lymphocytes; induction of immunocompetence

3

when are T cells first detected in the thymus

7th-8th week AOG

4

site of immune response generation

lymph nodes

5

organ vital for immune responses to blood-borne antigens and acts as waste disposal system

spleen

6

where is MALT found

Peyer's patches in the SI; lymphoid follicles in the appendix; tonsils in the pharynx; submucosal lymphoid tissue throughout the upper airways and bronchi

7

T-cell that kill microorganism by direct action on their surfaces

CD8+ or suppressor/cytotoxic cells

8

nonphagocytic cells that perform antibody dependent cell cytotoxicity

NK cells

9

protein that creates pores on cell membranes of target cells resulting in lysis

cytolysin

10

first line of defense against neonatal herpes virus infection

NK cells

11

time it takes for a PMN to mature from a myeloblast

14 days

12

term for migration toward site of microbial invasion

chemotaxis

13

contains granules with major basic protein that are toxic for helminths

eosinophils

14

effectors of immediate hypersensitivity that carry Fc receptors for IgE

mast cells and basophils

15

humoral elements

Ig; complement; cytokines; ab produced by B cells and plasma cells

16

largest Ig; earliest antibody in response to an Ag

IgM

17

most abundant Ig; can traverse the placental barrier

IgG

18

Ig synthesized in the submucosa of the respiratory GIT and exretory glands

IgA

19

Ig predominantly found on the human B lymphocytes like IgM; responsible for differentiation of B cell

IgD

20

Ig less than 10% of the serum; role in parasitic infxn and allergic rxn

IgE

21

main fxn is to mediate inflammatory processes and facilitate ingestion of opsonizing pathogens for phagocytosis

complement

22

complements common to both to classical and alternative pathways

C5-C9

23

main anaphylatoxins that provoke inflammation

C3a and C5A

24

complement that has a role in opsonization

C3b and C5b

25

acts as binding sites and signal transducers for interacting cells; aka phenotypic markers/MHC

Human Leukocyte antigens

26

cell surface proteins that identifiy a particular cell lineage; transduce signals that lead to ymphocyte activation; recognized by monoclonal antibodies; promote cell to cell interaction and adhesion

cluster differentiation(CD) antigen

27

due to release of mediators like histamine leukotriene serotonin after activation by allegens of specific cells(mast and basophils)

Type I (immediate hypersensitivity)

28

Type I rxns

asthma; allergic rhinitis; anaphylaxis

29

Ab bind to Ag and the immune complex formed activates complement leading to formation of MAC eventually leading to cell lysis

Type II (cytotoxic rxn)

30

Type II rxns

hemolytic dse; eryhtroblastosis fetalis; graft rejection; chronic keratitis; Goodpastures; blood transfusion rxn; ITP

31

Type III (immune-complex mediated) rxns

PSGN; serum sickness; RA; SLE; SJS; PAN

32

Ag deposited at local site initiate rxn from sensitized T-cells capable of destroying tissues or target cells

Type IV (delayed hypersensitivity)

33

Type IV rxns

PPD test; contact allergic dermatitis; syphilis; leprosy

34

dse characterized by a block in the dev't of pre-B cell to B cell due to a defect in the heavy chain gene rearrangement; low or absent Ig's; few or abseB cells

X-linked/Bruton's dse agammaglobulinemia

35

increased susceptibility to viral; fungal; and protozal infxn; aberrant thymus; low lymphocyte count; abnormal facies; hypothyroidism; congenital heart dse

DiGeorge Syndrome (CATCH-22)

36

selective defect in cell mediated immunity with susceptibility to chronic candida infection of the skin and mucous membranes; 50% are due to deficiency of adenosine deaminase

Severe Combine Immunodeficiency Disorder

37

when to suspect immunodeficiency

1 or more systemic bacterial infxn(sepsis; meningitis); 2 or more resp or documented bac infxn w/in 1 year; serious infxns occurring at unusual sites(liver; brain abscess); infxns with unusual pathogens; infxns with common childhood pathogens but of unusual severity

38

defect in X linked hyper-IgM syndrome

deficiency of CD40L on activated T cell

39

defect in transient agammaglobulinemia

delayed onset of maturation of normal IgG

40

defective response in bacterial polysaccharide and depressed IgM; gradual loss of humoral and immune response; thrombocytopenia and eczema

Wiskott-Aldrich Syndrome

41

deficiency in NADPH oxidase; recurrent infxn with CATALASE POSITIVE bacteria

chronic granulomatous disease

42

absence of CD18(common B chain of leukocyte integrin); Leukocytosis; failure to form pus; delay in umbilical cord sloughing

Leukocyte adhesion defect

43

granule structural defect; recurrent bacterial infxn; partial albinism

Chediak-Higashi Syndrome

44

deficiency in TNF-gamma; coarse facies; cold abscess; inc IgE

Job's Syndrome

45

screening tests for humoral diseases

serum IgA; antibody titers to vaccines

46

screening test for cell mediated diseases

candida skin test

47

screening test for macrophage diseases

nitroblue tetrazolium test; respiratory burst array

48

screening test for complement disease

CH50

49

allergic rhinitis that follows sensitization to wind-borne pollens of trees grasses &weeds; prevalence increases with age

seasonal AR