Immunotherapy

Question 1

IMHA 4 classic lab findings

Answer 1

spherocytes
agglutination
hyperbilirubinemia
regenerative anemia

Question 2

Primary differentials for IMHA

Answer 2

primary IMHA
blood loss
infectious (babesia)
toxin (lysis)

Question 3

prognostic factors for IMHA

Answer 3

leukocytosis
monocytosis
thrombocytopenia
increased BUN
hyperbilirubinemia
NOT severity of disease

Question 4

primary cause of death in most dogs with IMHA

Answer 4

thromboembolism

Question 5

treatment for IMHA

Answer 5

immunosuppression (pred or dexamethasone)
anticoagulation (clopidogrel)

Question 6

major differentials for IMTP

Answer 6

primary IMTP (APA)
thromboembolic disease
drug reaction
BM toxicity
chronic ehrichiosis
DIC

Question 7

IMHA diagnostics

Answer 7

CBC, Chem, UA
blood smear
coomb’s test/autoagglutination test

Question 8

IMTP diagnostics

Answer 8

APA test
AUS or CT for clot detection
platelet MPV
BM aspirate

Question 9

IMPA diagnostics

Answer 9

CBC, Chem
joint taps + cytology
rickettsial titers
joint fluid analysis = high protein, non-degenerate neutrophils

Question 10

IVIG MOA

Answer 10

immunosuppresses signal to macrophages in liver and spleen

good for refractory IMHA and IMTP

Question 11

Apoquel (oclacitinib) MOA

Answer 11

cytokine signaling inhibitors (JAK inhibitors)

Question 12

IMTP treatment

Answer 12

high dose dexamethasone
if life threatening give high dose rapid IV methylprednisolone
oral prednisolone for maintenance + mycophenolate or cyclosporine

Question 13

IMPA treatment

Answer 13

prednisone
if no response increased prednisone + cyclosporine or mycophenolate and doxycycline