Infectious Diseases - Kaplan Flashcards
Linezolid:
MC –> Thrombocytopenia.
–> It is a MAO inhibitor (avoid tyramine-containing foods).
Daptomycin:
CPK + LFT elevations.
Tigecycline:
Hepatotoxic + Causes nausea/diarrhea.
Colistin/Polymyxin:
Very toxic to the kidney and to the nerves.
–> Topical applications of the skin, eye, and ear.
Mefloquine:
Neuropsychiatric abnormalities: 1. Psychosis. 2. Hallucinations. 3. Seizures. Cardiac rhythm effects: 1. Bradycardia. 2. QT prolongation.
Doxycycline:
Photosensitivity rash.
Zanamivir:
May cause some wheezing, because it is administered by inhalation.
Ganciclovir:
Neutropenia.
Foscarnet:
- Nephrotoxicity.
- Urethral ulcers.
- Hypocalcemia.
- Hypomagnesemia.
Cidofovir:
Nephrotoxicity.
Valganciclovir:
- Seizures.
2. Neutropenia.
Drotrecogin:
MC –> Bleeding (activated ProteinC analog).
Influenza vaccine:
- Can induce a mild fever and mild muscle soreness.
- Contra when the patient is allergic to eggs.
- Live attenuated should NOT be given to pregnant or immunocompromised patients.
Pneumococcal vaccine:
Extremely safe - Local muscle soreness is the only significant side effect.
–> NO CONTRAINDICATIONS.
Clindamycin:
Often leads to diarrhea from C.difficile.
Metronidazole:
- Metallic taste.
- Disulfiram reaction (severe nausea + vomiting) with alcohol.
- Rarely –> Seizures + Neurological disorders.